Trisomy 4 identifies a subset of acute nonlymphocytic leukemias.

We present four patients with acute nonlymphocytic leukemia, one M2 and three M4 French-American-British (FAB) types and one patient with refractory anemia with excess of blasts in transformation who at diagnosis had trisomy of chromosome 4 as the primary karyotypic anomaly. This chromosome anomaly probably defines a previously undescribed subset of acute nonlymphoid leukemias. Hematologic characteristics commonly found in these patients were dysplastic features of all bone marrow lineages, suggesting that trisomy 4-associated disorders involve the early myeloid hematopoietic stem cell.

[1]  Y. S. Li,et al.  Correlation between chromosomal pattern, cytological subtypes, response to therapy, and survival in acute myeloid leukaemia. , 2009, Scandinavian journal of haematology.

[2]  D. Arthur,et al.  Therapy-related acute myeloid leukemia and myelodysplastic syndrome: a clinical and morphologic study of 65 cases. , 1985, Blood.

[3]  P. Nowell,et al.  Expression of the receptor for epidermal growth factor correlates with increased dosage of chromosome 7 in malignant melanoma , 1985, Somatic cell and molecular genetics.

[4]  S. O’Brien,et al.  Gene for T-cell growth factor: location on human chromosome 4q and feline chromosome B1. , 1984, Science.

[5]  G. Dewald,et al.  A possible specific chromosome marker for monocytic leukemia: three more patients with t(9;11)(p22;q24) and another with t(11;17)(q24;q21), each with acute monoblastic leukemia. , 1983, Cancer genetics and cytogenetics.

[6]  L. Chess,et al.  Functional subsets of human monocytes defined by monoclonal antibodies: a distinct subset of monocytes contains the cells capable of inducing the autologous mixed lymphocyte culture. , 1983, Journal of immunology.

[7]  J. Rowley,et al.  Chromosome pattern in childhood acute nonlymphocytic leukemia (ANLL) , 1982 .

[8]  A. Hagemeijer,et al.  Karyotypically distinct subpopulations in acute leukemia with specific growth requirements. , 1982, Blood.

[9]  C. Bloomfield,et al.  All patients with acute nonlymphocytic leukemia may have a chromosomal defect. , 1981, The New England journal of medicine.

[10]  G. Janossy,et al.  Distribution of t lymphocyte subsets in the human bone marrow and thymus: an analysis with monoclonal antibodies. , 1981, Journal of immunology.

[11]  E. Reinherz,et al.  Biochemical studies of the human thymocyte cell-surface antigens T6, T9 and T10 , 1981, Cell.

[12]  T. Lebien,et al.  A monoclonal antibody (BA-1) reactive with cells of human B lymphocyte lineage. , 1981, Journal of immunology.

[13]  L. Nadler,et al.  Characterization of a human B lymphocyte-specific antigen. , 1980, Journal of immunology.

[14]  E. Reinherz,et al.  Discrete stages of human intrathymic differentiation: analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[15]  J. Rowley,et al.  "Microgranular" acute promyelocytic leukemia: a distinct clinical, ultrastructural, and cytogenetic entity. , 1980, Blood.

[16]  E. Reinherz,et al.  Ia determinants on human T-cell subsets defined by monoclonal antibody. Activation stimuli required for expression , 1979, The Journal of experimental medicine.

[17]  F. Bollum.  Terminal deoxynucleotidyl transferase as a hematopoietic cell marker. , 1979, Blood.

[18]  H. Gralnick,et al.  Proposals for the Classification of the Acute Leukaemias French‐American‐British (FAB) Co‐operative Group , 1976, British journal of haematology.

[19]  A. de la Chapelle,et al.  Trisomy 8 in the bone marrow associated with high red cell glutathione reductase activity. , 1976, Blood.

[20]  Anita B. Roberts,et al.  Autocrine growth factors and cancer , 1985, Nature.

[21]  D. Harnden,et al.  An international system for human cytogenetic nomenclature (1985) : ISCN (1985) : report of the Standing Committee on Human Cytogenetic Nomenclature , 1985 .

[22]  T. Lebien,et al.  Chapter 7 – Utilization of Monoclonal Antibodies in the Study of Cell-Surface Antigens on Human B Lymphocytes1 , 1983 .

[23]  C. Junien,et al.  Inverted tandem duplication of the short arm of chromosome 8: a non-random de novo structural aberration in man. Localization of the gene for glutathione reductase in subband 8p21.1. , 1982, Annales de genetique.

[24]  J. Rowley,et al.  Chromosome pattern in childhood acute nonlymphocytic leukemia (ANLL). , 1982, Blood.

[25]  R. Berger,et al.  Cytogenetic studies on acute monocytic leukemia. , 1980, Leukemia research.

[26]  H. Heimpel.  Conventional Morphological Examination of Blood and Bone Marrow Cells in the Diagnosis of Preleukemic Syndromes , 1979 .