Selective deficits in cognition and memory in high-functioning parkinsonian patients.

To evaluate the profile and extent of cognitive deficits in Parkinson's disease, afflicted patients of exceptional professional distinction, who continue to function successfully in leadership positions, were compared neuropsychologically to neurologically normal individuals, matched for sex, age, education and professional standing. While patients showed relative preservation of verbal skills and higher executive function, they exhibited a significant reduction in episodic memory and visuospatial function. The observation of circumscribed impairment in this select group of Parkinsonian patients further implicates cognitive and memory deficits as consistent features of Parkinson's disease.

[1]  E. Kaplan,et al.  Cognitive fluctuations associated with on‐off phenomenon in Parkinson disease , 1982, Neurology.

[2]  C. Marsden,et al.  An investigation of the phenomenon of “set” in Parkinson's disease , 1988, Movement disorders : official journal of the Movement Disorder Society.

[3]  P. Osterrieth,et al.  Le test de copie d'une figure complexe; contribution à l'étude de la perception et de la mémoire. , 1944 .

[4]  E. Mohr,et al.  Cognitive concomitants of dopamine system stimulation in parkinsonian patients. , 1987, Journal of neurology, neurosurgery, and psychiatry.

[5]  C. Marsden,et al.  'Frontal' cognitive function in patients with Parkinson's disease 'on' and 'off' levodopa. , 1988, Brain : a journal of neurology.

[6]  F. Boller,et al.  Visuospatial impairment in Parkinson's disease. Role of perceptual and motor factors. , 1984, Archives of neurology.

[7]  Apostolos P. Georgopoulos,et al.  Cortico-basal ganglia relations and coding of motor performance , 1983 .

[8]  J. Saint-Cyr,et al.  DEMENTIA PREVALENCE IN PARKINSON'S DISEASE , 1985, The Lancet.

[9]  A. Rey.  Lexamen psychologique : Dans les cas d'encephalopathie traumatique (Les problemes) , 1941 .

[10]  C. Tanner,et al.  The autonomic nervous system in Gilles de la Tourette's syndrome , 1987, Movement disorders : official journal of the Movement Disorder Society.

[11]  A. Benton.  Contributions to Neuropsychological Assessment: A Clinical Manual , 1983 .

[12]  G. E. Alexander,et al.  Parallel organization of functionally segregated circuits linking basal ganglia and cortex. , 1986, Annual review of neuroscience.

[13]  M. Piccirilli,et al.  Frontal lobe dysfunction in Parkinson's disease: prognostic value for dementia? , 1989, European neurology.

[14]  H. Weingartner,et al.  Cognitive impairments in Parkinson's disease: Distinguishing between effort-demanding and automatic cognitive processes , 1984, Psychiatry Research.

[15]  A. Beck,et al.  An inventory for measuring depression. , 1961, Archives of general psychiatry.

[16]  C D Marsden,et al.  Visuospatial function in Parkinson's disease. , 1986, Brain : a journal of neurology.

[17]  N. Butters,et al.  Visuoperceptive deficits in long-term alcoholics and alcoholics with Korsakoff's psychosis. , 1977, Journal of studies on alcohol.

[18]  M. Kupersmith,et al.  Dementia in Parkinson disease , 1979, Annals of neurology.

[19]  T. Robbins,et al.  Planning and spatial working memory in Parkinson's disease. , 1988, Journal of neurology, neurosurgery, and psychiatry.

[20]  C. Marsden,et al.  Recent Developments in Parkinson's Disease , 1986 .

[21]  J. Parkinson.  An Essay on the Shaking Palsy , 2002 .

[22]  E. Mohr,et al.  Dopamine and memory function in Parkinson's disease , 1989, Movement disorders : official journal of the Movement Disorder Society.

[23]  B. Milner.  Effects of Different Brain Lesions on Card Sorting: The Role of the Frontal Lobes , 1963 .