The effect of experimentally induced hypervolemia on cardiac function in normal subjects and patients with mitral stenosis.

The physiologic differences between various types of laboratory preparations and unanesthetized man have been in part responsible for a wide diversion of opinion concerning the control of cardiac function in man (1). While numerous studies of the regulation of cardiac performance have been carried out in animals, relatively few studies have been done in man(2). The present work was undertaken in an attempt to clarify some of the mechanisms concerned with the control of cardiac function in man and has included studies in normal subjects and patients with mitral stenosis. During a study of the relation existing between renal and cardiac function, rapid intravenous infusions were given to normal individuals and patients with various types of cardiac disorders (3). When the infusions consisted of isotonic solutions of dextran 1 it was possible to analyze the relation of right heart filling pressure to cardiac output or right ventricular work, in a manner which closely simulated that used by Sarnoff and Berglund in the anesthetized dog (4), or Warren, Brannon, Weens and Stead in man (5). The present report is concerned with the effects on cardiac performance of varied degrees of expansion of the blood volume during 32 studies in 31 normal subjects and 16 studies in 15 patients with mitral stenosis.

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