Electrical Characterization of Glycerin: Water Mixtures: Implications for Use as a Coupling Medium in Microwave Tomography

We examine the broadband behavior of complex electrical properties of glycerin and water mixtures over the frequency range of 0.1–25.0 GHz, especially as they relate to using these liquids as coupling media for microwave tomographic imaging. Their combination is unique in that they are mutually miscible over the full range of concentrations, which allows them to be tailored to dielectric property matching for biological tissues. While the resultant mixture properties are partially driven by differences in the inherent low-frequency permittivity of each constituent, relaxation frequency shifts play a disproportionately larger role in increasing the permittivity dispersion while also dramatically increasing the effective conductivity over the frequency range of 1–3 GHz. For the full range of mixture ratios, the relaxation frequency shifts from 17.5 GHz for 0% glycerin to less than 0.1 GHz for 100% glycerin. Of particular interest is the fact that the conductivity stays above 1.0 S/m over the 1–3-GHz range for glycerin mixture ratios (70%–90% glycerin) we use for microwave breast tomography. The high level of attenuation is critical for suppressing unwanted multipath signals. This paper presents a full characterization of these liquids along with a discussion of their benefits and limitations in the context of microwave tomography.

[1]  K. Foster,et al.  Dielectric properties of tissues and biological materials: a critical review. , 1989, Critical reviews in biomedical engineering.

[2]  Paul M. Meaney,et al.  The Multidimensional Phase Unwrapping Integral and Applications to Microwave Tomographical Image Reconstruction , 2006, IEEE Transactions on Image Processing.

[3]  Jeremie Bourqui,et al.  Measurement and Analysis of Microwave Frequency Signals Transmitted through the Breast , 2012, Int. J. Biomed. Imaging.

[4]  Alexander Hartov,et al.  Electromagnetic breast imaging: average tissue property values in women with negative clinical findings. , 2004, Radiology.

[5]  K. Paulsen,et al.  Near-field microwave imaging of biologically-based materials using a monopole transceiver system , 1998 .

[6]  Zhang Linxi,et al.  Time-gating method for V/UHF antenna pattern measurement inside an anechoic chamber , 2008, 2008 International Conference on Microwave and Millimeter Wave Technology.

[7]  Paul M. Meaney,et al.  Surface Wave Multipath Signals in Near-Field Microwave Imaging , 2012, Int. J. Biomed. Imaging.

[8]  K. Foster,et al.  The UHF and microwave dielectric properties of normal and tumour tissues: variation in dielectric properties with tissue water content. , 1980, Physics in medicine and biology.

[9]  A. Bulyshev,et al.  Three-dimensional microwave tomography: experimental prototype of the system and vector Born reconstruction method , 1999, IEEE Transactions on Biomedical Engineering.

[10]  Takaaki Sato,et al.  Dynamical structure of oligo(ethylene glycol)s-water solutions studied by time domain reflectometry , 1998 .

[11]  Keith D Paulsen,et al.  Log transformation benefits parameter estimation in microwave tomographic imaging. , 2007, Medical physics.

[12]  Shireen D. Geimer,et al.  Quantification of 3-D field effects during 2-D microwave imaging , 2002, IEEE Transactions on Biomedical Engineering.

[13]  K. Paulsen,et al.  Initial clinical experience with microwave breast imaging in women with normal mammography. , 2007, Academic radiology.

[14]  S. Matsuoka.  Entropy, Free Volume, and Cooperative Relaxation , 1996, Journal of research of the National Institute of Standards and Technology.

[15]  S. Sudo,et al.  Broadband dielectric study of α–β separation for supercooled glycerol–water mixtures , 2002 .

[16]  Shireen D. Geimer,et al.  Mutual coupling in a tomographic imaging system , 2009, 2009 3rd European Conference on Antennas and Propagation.

[17]  John B Weaver,et al.  Integration of microwave tomography with magnetic resonance for improved breast imaging. , 2013, Medical physics.

[18]  K. Paulsen,et al.  IMPORTANCE OF USING A REDUCED CONTRAST COUPLING MEDIUM IN 2D MICROWAVE BREAST IMAGING , 2003 .

[19]  Fridon Shubitidze,et al.  Characterization of an Implicitly Resistively-Loaded Monopole Antenna in Lossy Liquid Media. , 2008, International journal of antennas and propagation.

[20]  Q. Liu,et al.  Active Microwave Imaging II: 3-D System Prototype and Image Reconstruction From Experimental Data , 2008, IEEE Transactions on Microwave Theory and Techniques.

[21]  M. Lindstrom,et al.  A large-scale study of the ultrawideband microwave dielectric properties of normal breast tissue obtained from reduction surgeries , 2007, Physics in medicine and biology.

[22]  K. Paulsen,et al.  Interplay between iteration step size and spatial filtering in microwave tomography , 2016, 2016 17th International Symposium on Antenna Technology and Applied Electromagnetics (ANTEM).

[23]  S. Sudo,et al.  Dielectric Relaxation Time and Relaxation Time Distribution of Alcohol−Water Mixtures , 2002 .

[24]  Jennifer J. Gibson,et al.  Electromagnetic breast imaging: results of a pilot study in women with abnormal mammograms. , 2007, Radiology.

[25]  Takamaro Kikkawa,et al.  Complex permittivities of breast tumor tissues obtained from cancer surgeries , 2014 .

[26]  Jeremie Bourqui,et al.  Antenna Evaluation for Ultra-Wideband Microwave Imaging , 2010 .

[27]  U. Kaatze.  Complex Permittivity of Water as a Function of Frequency and Temperature , 1989 .

[28]  Paul M. Meaney,et al.  Fast 3-D Tomographic Microwave Imaging for Breast Cancer Detection , 2012, IEEE Transactions on Medical Imaging.

[29]  L. Shafai,et al.  A Near-Field Dual Polarized (TE–TM) Microwave Imaging System , 2013, IEEE Transactions on Microwave Theory and Techniques.

[30]  Paul M. Meaney,et al.  Parallel-detection microwave spectroscopy system for breast imaging , 2004 .

[31]  B. Pogue,et al.  Microwave image reconstruction utilizing log-magnitude and unwrapped phase to improve high-contrast object recovery , 2001, IEEE Transactions on Medical Imaging.

[32]  E.C. Fear,et al.  Tissue Sensing Adaptive Radar for Breast Cancer Detection—Experimental Investigation of Simple Tumor Models , 2005, IEEE Transactions on Microwave Theory and Techniques.

[33]  P.M. Meaney,et al.  An active microwave imaging system for reconstruction of 2-D electrical property distributions , 1995, IEEE Transactions on Biomedical Engineering.

[34]  S. Sudo,et al.  Shape of dielectric relaxation curves of ethylene glycol oligomer–water mixtures , 1998 .

[35]  K D Paulsen,et al.  3D parallel-detection microwave tomography for clinical breast imaging. , 2014, The Review of scientific instruments.

[36]  A. Preece,et al.  Experimental and clinical results of breast cancer detection using UWB microwave radar , 2008, 2008 IEEE Antennas and Propagation Society International Symposium.

[37]  Keith D Paulsen,et al.  Microwave imaging for neoadjuvant chemotherapy monitoring: initial clinical experience , 2012, Breast Cancer Research.