The combination of meltblown and electrospinning for bone tissue engineering

Abstract Materials combining meltblown and electrospinning products with hydroxyapatite powder as potential scaffolds for bone tissue engineering are presented here. The combination of these technologies and parameters and final micro-nanofibrous products are introduced too. The in-vitro testing compared meltblown material, meltblown material with sputtered particles, meltblown material combined with electrospun fibers, meltblown material combined with electrospun fibers and sputtered particles. All the fibrous materials are produced from polycaprolactone. The first in-vitro tests showed the high potential of developed composite materials in bone tissue engineering. The structure of the tested materials allows osteoblasts to proliferate into the sample inner structure with the significant contribution of nanofiber content to cell proliferation.

[1]  B. Shi,et al.  Enhanced Mineralization of PLA Meltblown Materials Due to Plasticization , 2010 .

[2]  F. Ko,et al.  Biomedical applications of nanofibers , 2011 .

[3]  G. Wnek,et al.  Encyclopedia of biomaterials and biomedical engineering , 2008 .

[4]  Xingyu Jiang,et al.  Recent advances in electrospinning technology and biomedical applications of electrospun fibers. , 2014, Journal of materials chemistry. B.

[5]  A. Mikos,et al.  Electrospinning of polymeric nanofibers for tissue engineering applications: a review. , 2006, Tissue engineering.

[6]  P. Kochová,et al.  Elastic three‐dimensional poly (ε‐caprolactone) nanofibre scaffold enhances migration, proliferation and osteogenic differentiation of mesenchymal stem cells , 2013, Cell proliferation.

[7]  H. Kim,et al.  Electrospinning biomedical nanocomposite fibers of hydroxyapatite/poly(lactic acid) for bone regeneration. , 2006, Journal of biomedical materials research. Part A.

[8]  D. Kaplan,et al.  Porosity of 3D biomaterial scaffolds and osteogenesis. , 2005, Biomaterials.

[9]  H. Ohgushi,et al.  BMP-induced osteogenesis on the surface of hydroxyapatite with geometrically feasible and nonfeasible structures: topology of osteogenesis. , 1998, Journal of biomedical materials research.

[10]  Yanbo Liu,et al.  Preliminary study on fiber splitting of bicomponent meltblown fibers , 2004 .

[11]  J. L. Gomez Ribelles,et al.  Poly(ɛ-caprolactone) Electrospun Scaffolds Filled with Nanoparticles. Production and Optimization According to Taguchi's Methodology , 2014 .

[12]  J. Chvojka,et al.  Cell penetration to nanofibrous scaffolds , 2014, Cell adhesion & migration.

[13]  S F Hulbert,et al.  Potential of ceramic materials as permanently implantable skeletal prostheses. , 1970, Journal of biomedical materials research.

[14]  S. Ramakrishna,et al.  Mimicking nanofibrous hybrid bone substitute for mesenchymal stem cells differentiation into osteogenesis. , 2013, Macromolecular bioscience.

[15]  Yun-Ze Long,et al.  Advances in three-dimensional nanofibrous macrostructures via electrospinning , 2014 .

[16]  Satish Kumar,et al.  Meltblown fibers: Influence of viscosity and elasticity on diameter distribution , 2010 .

[17]  Stephen J. Russell,et al.  Handbook of Nonwovens , 2007 .

[18]  Benjamin Chu,et al.  Functional electrospun nanofibrous scaffolds for biomedical applications. , 2007, Advanced drug delivery reviews.