The concept of interactive load was proposed in this paper. The renewable energy consumption can be achieved in a wide range by matching the energy output with the interactive loads. Firstly, the theories, methods and technologies of comprehensive interaction among generation, transmission, distribution and consumption were introduced. Then a new operation mode of power gird was proposed, through the constructions of transmission interactive platform and distribution interactive platform. The two-way communication network was built to support the platforms to achieve the depth perception, accurate prediction and intelligent decision of each part. Finally, the integrated demonstration project with comprehensive interaction was constructed in Ningxia Hui Autonomous Region. The interactions between each link, including traditional generators, concentrated renewable energy, industrial consumers, transmission network and distribution network, were realized on the transmission interactive platform. The interactions between grid and various loads, such as charging and swapping stations of electric vehicles, smart residential districts, and microgrid, were developed on the distribution interactive platform. The demonstration shows that the proposed interactive operation mode can enhance the consumption ability of renewable energy, can promote the levels of safety, economy and environment of power gird.