The Drug Guru Project
暂无分享,去创建一个
J. Phillip Bowen | Kent D. Stewart | Jason Shanley | Karam B. Alsayyed Ahmed | Jason P. Shanley | K. Stewart | J. Bowen | Karam Ahmed
[1] Richard A. Lewis. A general method for exploiting QSAR models in lead optimization. , 2005, Journal of medicinal chemistry.
[2] W. Price,et al. Nonpeptide angiotensin II receptor antagonists: the discovery of a series of N-(biphenylylmethyl)imidazoles as potent, orally active antihypertensives. , 1991, Journal of medicinal chemistry.
[3] E. LaVoie,et al. Bioisosterism: A Rational Approach in Drug Design. , 1996, Chemical reviews.
[4] Ajay,et al. Kinase patent space visualization using chemical replacements. , 2006, Journal of medicinal chemistry.
[5] Z. Rankovic,et al. Medicinal chemistry of hERG optimizations: Highlights and hang-ups. , 2006, Journal of medicinal chemistry.
[6] Christopher A. Lipinski,et al. Chapter 27. Bioisosterism in Drug Design , 1986 .
[7] Xiaoqi Chen,et al. Chapter 32. The use of bioisosteric groups in lead optimization , 2003 .
[8] Markus Wagener,et al. The Quest for Bioisosteric Replacements , 2006, J. Chem. Inf. Model..
[9] A. Spatola. Chapter 19. Peptides of the Hypothalamus , 1981 .
[10] L. Hasvold,et al. Synthesis and structure-activity relationships of 2-pyridones: a novel series of potent DNA gyrase inhibitors as antibacterial agents. , 1996, Journal of medicinal chemistry.
[11] Robert P. Sheridan,et al. Molecular Transformations as a Way of Finding and Exploiting Consistent Local QSAR , 2006, J. Chem. Inf. Model..
[12] István Ujváry,et al. Extended Summary: BIOSTER—a database of structurally analogous compounds , 1997 .
[13] J. Rudinger. The Design of Peptide Hormone Analogs , 1971 .
[14] N. Meanwell. Synopsis of some recent tactical application of bioisosteres in drug design. , 2011, Journal of medicinal chemistry.
[15] A. D. Rodrigues,et al. Design and biological activity of (S)-4-(5-([1-(3-chlorobenzyl)-2-oxopyrrolidin-3-ylamino]methyl)imidazol-1-ylmethyl)benzonitrile, a 3-aminopyrrolidinone farnesyltransferase inhibitor with excellent cell potency. , 2001, Journal of medicinal chemistry.
[16] Peter Ertl,et al. Cheminformatics Analysis of Organic Substituents: Identification of the Most Common Substituents, Calculation of Substituent Properties, and Automatic Identification of Drug-like Bioisosteric Groups , 2003, J. Chem. Inf. Comput. Sci..
[17] Gavin Harper,et al. Drug rings database with web interface. A tool for identifying alternative chemical rings in lead discovery programs. , 2003, Journal of medicinal chemistry.
[18] A Burger,et al. Isosterism and bioisosterism in drug design. , 1991, Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques.
[19] Robert P. Sheridan,et al. The Most Common Chemical Replacements in Drug-Like Compounds , 2002, J. Chem. Inf. Comput. Sci..
[20] P. Hajduk,et al. Cheminformatic tools for medicinal chemists. , 2010, Journal of medicinal chemistry.
[21] T. Lampe,et al. Imidazo[5,1-f][1,2,4]triazin-4(3H)-ones, a new class of potent PDE 5 inhibitors , 2002 .
[22] Andrew G. Leach,et al. Matched molecular pairs as a guide in the optimization of pharmaceutical properties; a study of aqueous solubility, plasma protein binding and oral exposure. , 2006, Journal of medicinal chemistry.
[23] C. Thornber,et al. Isosterism and molecular modification in drug design , 1979 .
[24] P. Hajduk,et al. Statistical analysis of the effects of common chemical substituents on ligand potency. , 2008, Journal of medicinal chemistry.
[25] K. Stewart,et al. Drug Guru: a computer software program for drug design using medicinal chemistry rules. , 2006, Bioorganic & medicinal chemistry.