Structural basis for therapeutic inhibition of complement C5
暂无分享,去创建一个
Hans Elmlund | N. M. Barber | Steven Johnson | Yang I Li | Susan M Lea | M. M. Jore | H. Elmlund | Steven Johnson | S. Lea | D. Sheppard | M. Nunn | Matthijs M Jore | Devon Sheppard | Natalie M Barber | Miles A Nunn | Yang I Li | Yanglonghao Li
[1] David Baker,et al. Advances, interactions, and future developments in the CNS, Phenix, and Rosetta structural biology software systems. , 2013, Annual review of biophysics.
[2] T. Woodruff,et al. Is the Complement Activation Product C3a a Proinflammatory Molecule? Re-evaluating the Evidence and the Myth , 2015, The Journal of Immunology.
[3] John D Lambris,et al. Applying complement therapeutics to rare diseases. , 2015, Clinical immunology.
[4] Molecular insights into the surface-specific arrangement of complement C5 convertase enzymes , 2015, BMC Biology.
[5] C. Hack,et al. Functional characterization of the lectin pathway of complement in human serum. , 2003, Molecular immunology.
[6] N. Friedman,et al. Trinity: reconstructing a full-length transcriptome without a genome from RNA-Seq data , 2011, Nature Biotechnology.
[7] J. Ribeiro,et al. Function, mechanism and evolution of the moubatin-clade of soft tick lipocalins. , 2008, Insect biochemistry and molecular biology.
[8] B. Ryffel,et al. Bifunctional Lipocalin Ameliorates Murine Immune Complex-induced Acute Lung Injury , 2013, The Journal of Biological Chemistry.
[9] G. Paesen,et al. Complement Inhibitor of C5 Activation from the Soft Tick Ornithodoros moubata , 2005, The Journal of Immunology.
[10] John D. Lambris,et al. Complement in Immune and Inflammatory Disorders: Pathophysiological Mechanisms , 2013, The Journal of Immunology.
[11] A. Koster,et al. Insights into complement convertase formation based on the structure of the factor B‐cobra venom factor complex , 2009, The EMBO journal.
[12] Ye Tian,et al. Improved chemical shift prediction by Rosetta conformational sampling , 2012, Journal of Biomolecular NMR.
[13] Á. Szilágyi,et al. Structural Basis for the Function of Complement Component C4 within the Classical and Lectin Pathways of Complement , 2015, The Journal of Immunology.
[14] H. Kozono,et al. Covalent association of C3b with C4b within C5 convertase of the classical complement pathway , 1987, The Journal of experimental medicine.
[15] P. Güntert. Automated NMR structure calculation with CYANA. , 2004, Methods in molecular biology.
[16] H. Kozono,et al. C5 convertase of the alternative complement pathway: covalent linkage between two C3b molecules within the trimolecular complex enzyme. , 1988, Journal of immunology.
[17] J. Köhl,et al. Novel roles for complement receptors in T cell regulation and beyond. , 2013, Molecular immunology.
[18] K. Henrick,et al. Inference of macromolecular assemblies from crystalline state. , 2007, Journal of molecular biology.
[19] N. Rawal,et al. Formation of High Affinity C5 Convertase of the Classical Pathway of Complement* , 2003, Journal of Biological Chemistry.
[20] W. Vogt,et al. A new function of the activated third component of complement: binding to C5, an essential step for C5 activation. , 1978, Immunology.
[21] Dominika Elmlund,et al. Cryogenic electron microscopy and single-particle analysis. , 2015, Annual review of biochemistry.
[22] Randy J. Read,et al. Overview of the CCP4 suite and current developments , 2011, Acta crystallographica. Section D, Biological crystallography.
[23] L. Matis,et al. Inhibition of complement activity by humanized anti-C5 antibody and single-chain Fv. , 1996, Molecular immunology.
[24] Conrad C. Huang,et al. UCSF Chimera, MODELLER, and IMP: an integrated modeling system. , 2012, Journal of structural biology.
[25] D. Fearon,et al. C3 requirements for formation of alternative pathway C5 convertase. , 1976, Journal of immunology.
[26] R. Schreiber,et al. A molecular concept of the properdin pathway. , 1976, Proceedings of the National Academy of Sciences of the United States of America.
[27] Piet Gros,et al. Structure of C3b reveals conformational changes that underlie complement activity , 2006, Nature.
[28] Dominika Elmlund,et al. SIMPLE: Software for ab initio reconstruction of heterogeneous single-particles. , 2012, Journal of structural biology.
[29] Kutty Selva Nandakumar,et al. Inhibiting the C5-C5a receptor axis. , 2011, Molecular immunology.
[30] T. Mollnes,et al. Strategies of therapeutic complement inhibition. , 2006, Molecular immunology.
[31] N. S. Laursen,et al. Substrate recognition by complement convertases revealed in the C5–cobra venom factor complex , 2011, The EMBO journal.
[32] B. Morgan,et al. The membrane attack complex as an inflammatory trigger. , 2016, Immunobiology.
[33] B. Morgan,et al. Prevention of experimental autoimmune myasthenia gravis by rat Crry-Ig: A model agent for long-term complement inhibition in vivo , 2008, Molecular immunology.
[34] John D Lambris,et al. Complement: a key system for immune surveillance and homeostasis , 2010, Nature Immunology.
[35] N. Rawal,et al. Structure and function of complement C5 convertase enzymes. , 2001, Biochemical Society transactions.
[36] P. Emsley,et al. Features and development of Coot , 2010, Acta crystallographica. Section D, Biological crystallography.
[37] S. Grzesiek,et al. NMRPipe: A multidimensional spectral processing system based on UNIX pipes , 1995, Journal of biomolecular NMR.
[38] John D Lambris,et al. Ornithodoros moubata Complement Inhibitor Is an Equally Effective C5 Inhibitor in Pigs and Humans , 2011, The Journal of Immunology.
[39] N. Rawal,et al. Formation of high-affinity C5 convertases of the alternative pathway of complement. , 2000, Journal of immunology.
[40] P. Roversi,et al. The Structure of OMCI, a Novel Lipocalin Inhibitor of the Complement System , 2007, Journal of molecular biology.
[41] N. S. Laursen,et al. Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus , 2010, Proceedings of the National Academy of Sciences.
[42] Dominika Elmlund,et al. PRIME: probabilistic initial 3D model generation for single-particle cryo-electron microscopy. , 2013, Structure.
[43] J. Nishimura. [Genetic variants in C5 and poor response to eculizumab]. , 2015, [Rinsho ketsueki] The Japanese journal of clinical hematology.
[44] John Quackenbush,et al. Genes transcribed in the salivary glands of female Rhipicephalus appendiculatus ticks infected with Theileria parva. , 2004, Insect biochemistry and molecular biology.
[45] Wen Jiang,et al. EMAN2: an extensible image processing suite for electron microscopy. , 2007, Journal of structural biology.
[46] N. S. Laursen,et al. Structure of and influence of a tick complement inhibitor on human complement component 5 , 2008, Nature Immunology.
[47] Randy J. Read,et al. Phaser crystallographic software , 2007, Journal of applied crystallography.
[48] S. Law,et al. The internal thioester and the covalent binding properties of the complement proteins C3 and C4 , 1997, Protein science : a publication of the Protein Society.
[49] D. Ricklin,et al. Structural and functional implications of the alternative complement pathway C 3 convertase stabilized by a staphylococcal inhibitor , 2009 .
[50] R. Kini,et al. Structure, function and evolution of three-finger toxins: mini proteins with multiple targets. , 2010, Toxicon : official journal of the International Society on Toxinology.
[51] John D Lambris,et al. The role of complement in inflammatory diseases from behind the scenes into the spotlight. , 2007, The American journal of pathology.
[52] R. Ogata,et al. Distal Recognition Site for Classical Pathway Convertase Located in the C345C/Netrin Module of Complement Component C51 , 2000, The Journal of Immunology.
[53] W. Boyar,et al. Solution structure of a unique C5a semi‐synthetic antagonist: Implications in receptor binding , 1997, Protein science : a publication of the Protein Society.
[54] N. Rawal,et al. Functional Role of the Noncatalytic Subunit of Complement C5 Convertase1 , 2000, The Journal of Immunology.