IRILmap: linkage map distance correction for intermated recombinant inbred lines/advanced recombinant inbred strains

Intermated Recombinant Inbred Lines (IRILs) in plants, or Advanced Recombinant Inbred Strains in animals, are constructed by carrying out generations of intermating between F2 individuals before starting recurrent inbreeding generations by selfing or sib-mating. IRILs are powerful for high-resolution genetic mapping because they have undergone more recombination than usual Recombinant Inbred Lines (RILs). However, there is no mapping software able to generate actual centiMorgan distances from the segregation data obtained with IRILs. IRILmap software converts genetic distances computed with any linkage mapping program designed for RILs, so that IRIL-derived data can be used to get actual centiMorgan distances, directly comparable to F2, backcross or RIL-derived maps.

[1]  D. Grant,et al.  Expanding the genetic map of maize with the intermated B73 × Mo17 (IBM) population , 2002, Plant Molecular Biology.

[2]  M. Cooper,et al.  On the determination of recombination rates in intermated recombinant inbred populations. , 2003, Genetics.

[3]  Robert W. Williams,et al.  A new set of BXD recombinant inbred lines from advanced intercross populations in mice , 2004, BMC Genetics.

[4]  M. Daly,et al.  MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. , 1987, Genomics.

[5]  C. Haley,et al.  Fine mapping of trypanosomiasis resistance loci in murine advanced intercross lines , 2000, Mammalian Genome.

[6]  F. Teuscher,et al.  The Map Expansion Obtained With Recombinant Inbred Strains and Intermated Recombinant Inbred Populations for Finite Generation Designs , 2005, Genetics.

[7]  P. Stam,et al.  Construction of integrated genetic linkage maps by means of a new computer package: JOINMAP. , 1993 .

[8]  D. D. Kosambi.  The estimation of map distances from recombination values. , 1943 .

[9]  A. Paterson,et al.  Erratum: Genome-wide high-resolution mapping by recurrent intermating using Arabidopsis thaliana as a model (Genetics (January, 1996) 142 (247- 258)) , 1996 .

[10]  J B Haldane,et al.  Inbreeding and Linkage. , 1931, Genetics.

[11]  S. C. Liu,et al.  Genome-wide high-resolution mapping by recurrent intermating using Arabidopsis thaliana as a model. , 1996, Genetics.