The BDNF val66met Polymorphism Affects Activity-Dependent Secretion of BDNF and Human Memory and Hippocampal Function

[1]  M. Egan,et al.  Serotonin Transporter Genetic Variation and the Response of the Human Amygdala , 2002, Science.

[2]  E. Kandel.  The Molecular Biology of Memory Storage: A Dialogue Between Genes and Synapses , 2001, Science.

[3]  R. Heumann,et al.  Synaptic secretion of BDNF after high‐frequency stimulation of glutamatergic synapses , 2001, The EMBO journal.

[4]  J B Poline,et al.  Evidence for abnormal cortical functional connectivity during working memory in schizophrenia. , 2001, The American journal of psychiatry.

[5]  D. Boomsma,et al.  Editorial: Genetics of Brain Function and Cognition , 2001, Behavior genetics.

[6]  W. Tyler,et al.  Protein Synthesis-dependent and -independent Regulation of Hippocampal Synapses by Brain-derived Neurotrophic Factor* , 2001, The Journal of Biological Chemistry.

[7]  Michael F Egan,et al.  Relative risk for cognitive impairments in siblings of patients with schizophrenia , 2001, Biological Psychiatry.

[8]  R. Straub,et al.  Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[9]  N. Seidah,et al.  Biosynthesis and Post-translational Processing of the Precursor to Brain-derived Neurotrophic Factor* , 2001, The Journal of Biological Chemistry.

[10]  Y. Ishikawa,et al.  Biological characterization and optical imaging of brain‐derived neurotrophic factor‐green fluorescent protein suggest an activity‐dependent local release of brain‐derived neurotrophic factor in neurites of cultured hippocampal neurons , 2001, Journal of neuroscience research.

[11]  J. Price,et al.  Mild cognitive impairment represents early-stage Alzheimer disease. , 2001, Archives of neurology.

[12]  Mu-ming Poo,et al.  Neurotrophins as synaptic modulators , 2001, Nature Reviews Neuroscience.

[13]  R. Coppola,et al.  Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited. , 2000, Cerebral cortex.

[14]  R. Nicoll,et al.  The Role of Brain-Derived Neurotrophic Factor Receptors in the Mature Hippocampus: Modulation of Long-Term Potentiation through a Presynaptic Mechanism involving TrkB , 2000, The Journal of Neuroscience.

[15]  Kiyofumi Yamada,et al.  Involvement of Brain-Derived Neurotrophic Factor in Spatial Memory Formation and Maintenance in a Radial Arm Maze Test in Rats , 2000, The Journal of Neuroscience.

[16]  Mark S. Cohen,et al.  Patterns of brain activation in people at risk for Alzheimer's disease. , 2000, The New England journal of medicine.

[17]  P. Osten,et al.  Mutagenesis Reveals a Role for ABP/GRIP Binding to GluR2 in Synaptic Surface Accumulation of the AMPA Receptor , 2000, Neuron.

[18]  M. Egan,et al.  Relative risk of attention deficits in siblings of patients with schizophrenia. , 2000, The American journal of psychiatry.

[19]  N. Rothman,et al.  Population stratification in epidemiologic studies of common genetic variants and cancer: quantification of bias. , 2000, Journal of the National Cancer Institute.

[20]  Barry J. Everitt,et al.  Rapid and selective induction of BDNF expression in the hippocampus during contextual learning , 2000, Nature Neuroscience.

[21]  N. Seidah,et al.  Neurotrophin-3 Sorts to the Constitutive Secretory Pathway of Hippocampal Neurons and Is Diverted to the Regulated Secretory Pathway by Coexpression with Brain-Derived Neurotrophic Factor , 2000, The Journal of Neuroscience.

[22]  O. Andreassen,et al.  Nonlinear Decrease over Time in N‐Acetyl Aspartate Levels in the Absence of Neuronal Loss and Increases in Glutamine and Glucose in Transgenic Huntington's Disease Mice , 2000, Journal of neurochemistry.

[23]  P. Greengard,et al.  Synapsins as mediators of BDNF-enhanced neurotransmitter release , 2000, Nature Neuroscience.

[24]  A. Roses,et al.  Apolipoprotein E and Alzheimer's disease. , 1996, Annual review of neuroscience.

[25]  B. Lu,et al.  Modulation of hippocampal synaptic transmission and plasticity by neurotrophins. , 2000, Progress in brain research.

[26]  C. Wihler,et al.  Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[27]  Robert Plomin,et al.  Genetics and general cognitive ability , 1999, Nature.

[28]  Tobias Bonhoeffer,et al.  Essential Role for TrkB Receptors in Hippocampus-Mediated Learning , 1999, Neuron.

[29]  L. Zhang,et al.  Impairments in High-Frequency Transmission, Synaptic Vesicle Docking, and Synaptic Protein Distribution in the Hippocampus of BDNF Knockout Mice , 1999, The Journal of Neuroscience.

[30]  B. Lu,et al.  Signaling mechanisms mediating BDNF modulation of synaptic plasticity in the hippocampus. , 1999, Learning & memory.

[31]  N. Seidah,et al.  Differential Sorting of Nerve Growth Factor and Brain-Derived Neurotrophic Factor in Hippocampal Neurons , 1999, The Journal of Neuroscience.

[32]  R. Coppola,et al.  Physiological characteristics of capacity constraints in working memory as revealed by functional MRI. , 1999, Cerebral cortex.

[33]  Alessandro Bertolino,et al.  Hippocampal N-acetyl aspartate in unaffected siblings of patients with schizophrenia: a possible intermediate neurobiological phenotype , 1998, Biological Psychiatry.

[34]  A D Roses,et al.  Apolipoprotein E and ALzheimer's Disease: The Tip of the Susceptibility Iceberg , 1998, Annals of the New York Academy of Sciences.

[35]  B. Lu,et al.  Presynaptic Modulation of Synaptic Transmission and Plasticity by Brain-Derived Neurotrophic Factor in the Developing Hippocampus , 1998, The Journal of Neuroscience.

[36]  Stephen Ashwal,et al.  Proton Magnetic Resonance Spectroscopy: An Emerging Technology in Pediatric Neurology Research , 1998, Pediatric Research.

[37]  P. Grasby,et al.  PET activation of the medial temporal lobe in learning. , 1998, Brain : a journal of neurology.

[38]  Hyejin Kang,et al.  A role for BDNF in the late-phase of hippocampal long-term potentiation , 1998, Neuropharmacology.

[39]  T. Ikeuchi,et al.  Comparison of survival-promoting effects of brain-derived neurotrophic factor and neurotrophin-3 on PC12h cells stably expressing TrkB receptor. , 1998, Journal of biochemistry.

[40]  E. Kandel,et al.  Cognitive Neuroscience and the Study of Memory , 1998, Neuron.

[41]  B. Dastugue,et al.  [Apolipoprotein E and Alzheimer's disease]. , 1998, Annales de biologie clinique.

[42]  S. Linnarsson,et al.  Learning Deficit in BDNF Mutant Mice , 1997, The European journal of neuroscience.

[43]  G Tedeschi,et al.  Regionally specific pattern of neurochemical pathology in schizophrenia as assessed by multislice proton magnetic resonance spectroscopic imaging. , 1996, The American journal of psychiatry.

[44]  C. Shatz,et al.  Synaptic Activity and the Construction of Cortical Circuits , 1996, Science.

[45]  Giuseppe Esposito,et al.  Dextroamphetamine Enhances “Neural Network-Specific” Physiological Signals: A Positron-Emission Tomography rCBF Study , 1996, The Journal of Neuroscience.

[46]  B. Lu,et al.  Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus , 1996, Nature.

[47]  Ted Abel,et al.  Recombinant BDNF Rescues Deficits in Basal Synaptic Transmission and Hippocampal LTP in BDNF Knockout Mice , 1996, Neuron.

[48]  Howard J. Federoff,et al.  Regulated Release and Polarized Localization of Brain-Derived Neurotrophic Factor in Hippocampal Neurons , 1996, Molecular and Cellular Neuroscience.

[49]  N. Seidah,et al.  Cellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian proprotein convertases , 1996, FEBS letters.

[50]  G J Barker,et al.  Proton magnetic resonance spectroscopy: an in vivo method of estimating hippocampal neuronal depletion in schizophrenia , 1995, Psychological Medicine.

[51]  T Bonhoeffer,et al.  Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[52]  I. Black,et al.  Brain-derived neurotrophic factor rapidly enhances synaptic transmission in hippocampal neurons via postsynaptic tyrosine kinase receptors. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[53]  A D Roses,et al.  Apolipoprotein E and Alzheimer disease. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[54]  T. Bliss,et al.  A synaptic model of memory: long-term potentiation in the hippocampus , 1993, Nature.

[55]  P. Schwartzkroin,et al.  Neurotrophin expression in rat hippocampal slices: A stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs , 1992, Neuron.

[56]  Ravi S. Menon,et al.  Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[57]  L. Voronin,et al.  Long-term potentiation in the hippocampus , 1983, Neuroscience.

[58]  Burton S. Rosner,et al.  Neuropharmacology , 1958, Nature.