Signalling: STATs: transcriptional control and biological impact

Extracellular proteins bound to cell-surface receptors can change nuclear gene expression patterns in minutes, with far-reaching consequences for development, cell growth and homeostasis. The signal transducer and activator of transcription (STAT) proteins are among the most well studied of the latent cytoplasmic signal-dependent transcription-factor pathways. In addition to several roles in normal cell decisions, dysregulation of STAT function contributes to human disease, making the study of these proteins an important topic of current research.

[1]  C. Nüsslein-Volhard,et al.  Mutations affecting segment number and polarity in Drosophila , 1980, Nature.

[2]  R. Aebersold,et al.  The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[3]  J. Darnell,et al.  Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. , 1992, Science.

[4]  R. Aebersold,et al.  Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[5]  J. Darnell,et al.  Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. , 1994, Science.

[6]  N. Copeland,et al.  A novel cytokine‐inducible gene CIS encodes an SH2‐containing protein that binds to tyrosine‐phosphorylated interleukin 3 and erythropoietin receptors. , 1995, The EMBO journal.

[7]  R. Jove,et al.  Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein. , 1995, Science.

[8]  Ursula Klingmüller,et al.  Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals , 1995, Cell.

[9]  Dwight C. Look,et al.  Stat1 Depends on Transcriptional Synergy with Sp1 (*) , 1995, The Journal of Biological Chemistry.

[10]  J. Darnell,et al.  Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[11]  B. Berk,et al.  Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor , 1995, Nature.

[12]  J. Stavnezer,et al.  Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF- IL-4, a C/EBP family member and NF-kappa B/p50 , 1995, The Journal of experimental medicine.

[13]  L. Sanders,et al.  Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[14]  S Goelz,et al.  Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1 , 1995, Molecular and cellular biology.

[15]  H. Luo,et al.  An amino acid substitution in the Drosophila hopTum‐l Jak kinase causes leukemia‐like hematopoietic defects. , 1995, The EMBO journal.

[16]  R. Schreiber,et al.  Stat recruitment by tyrosine-phosphorylated cytokine receptors: an ordered reversible affinity-driven process. , 1995, Immunity.

[17]  Y. Tan,et al.  Activation and association of Stat3 with Src in v-Src-transformed cell lines , 1996, Molecular and cellular biology.

[18]  T. Hoey,et al.  Cooperative DNA Binding and Sequence-Selective Recognition Conferred by the STAT Amino-Terminal Domain , 1996, Science.

[19]  D. Levy,et al.  ISGF3γ p48, a specificity switch for interferon activated transcription factors , 1996 .

[20]  K. Shuai,et al.  Enhancement of antiproliferative activity of gamma interferon by the specific inhibition of tyrosine dephosphorylation of Stat1 , 1996, Molecular and cellular biology.

[21]  E. Wimmer,et al.  Inhibition of basal transcription by poliovirus: a virus- encoded protease (3Cpro) inhibits formation of TBP-TATA box complex in vitro , 1996, Journal of virology.

[22]  R. Schreiber,et al.  Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway , 1996, Cell.

[23]  B. Chait,et al.  DNA binding of in vitro activated Stat1 alpha, Stat1 beta and truncated Stat1: interaction between NH2‐terminal domains stabilizes binding of two dimers to tandem DNA sites. , 1996, The EMBO journal.

[24]  M. David,et al.  Activation of Protein Kinase A Inhibits Interferon Induction of the Jak/Stat Pathway in U266 Cells (*) , 1996, The Journal of Biological Chemistry.

[25]  Norbert Perrimon,et al.  marelle Acts Downstream of the Drosophila HOP/JAK Kinase and Encodes a Protein Similar to the Mammalian STATs , 1996, Cell.

[26]  H. Luo,et al.  A JAK-STAT pathway regulates wing vein formation in Drosophila. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[27]  B. Groner,et al.  Functional interactions between Stat5 and the glucocorticoid receptor , 1996, Nature.

[28]  D. Levy,et al.  Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease , 1996, Cell.

[29]  M. Vignais,et al.  Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins , 1996, Molecular and cellular biology.

[30]  D. Levy,et al.  Roles of JAKs in activation of STATs and stimulation of c-fos gene expression by epidermal growth factor , 1996, Molecular and cellular biology.

[31]  Claude Desplan,et al.  Identification of a Stat Gene That Functions in Drosophila Development , 1996, Cell.

[32]  J. Darnell.  STATs and gene regulation. , 1997, Science.

[33]  P Jay,et al.  Specific inhibition of Stat3 signal transduction by PIAS3. , 1997, Science.

[34]  L. Her,et al.  Inhibition of Ran guanosine triphosphatase-dependent nuclear transport by the matrix protein of vesicular stomatitis virus. , 1997, Science.

[35]  T. Hirano,et al.  Extracellular signal‐dependent nuclear import of Stat1 is mediated by nuclear pore‐targeting complex formation with NPI‐1, but not Rch1 , 1997, The EMBO journal.

[36]  J. Hagood,et al.  STAT3 Acts as a Co-activator of Glucocorticoid Receptor Signaling* , 1997, The Journal of Biological Chemistry.

[37]  J. O’Shea.  Jaks, STATs, cytokine signal transduction, and immunoregulation: are we there yet? , 1997, Immunity.

[38]  S. Akira,et al.  Structure and function of a new STAT-induced STAT inhibitor , 1997, Nature.

[39]  L. Hennighausen,et al.  Stat5a is mandatory for adult mammary gland development and lactogenesis. , 1997, Genes & development.

[40]  S. Akira,et al.  Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[41]  Aseem Kumar,et al.  Defective TNF-α-Induced Apoptosis in STAT1-Null Cells Due to Low Constitutive Levels of Caspases , 1997 .

[42]  Takaho A. Endo,et al.  A new protein containing an SH2 domain that inhibits JAK kinases , 1997, Nature.

[43]  D. Levy,et al.  Regulation of Interferon-α Responsiveness by the Duration of Janus Kinase Activity* , 1997, The Journal of Biological Chemistry.

[44]  B. Mach,et al.  Activation of the MHC class II transactivator CIITA by interferon-gamma requires cooperative interaction between Stat1 and USF-1. , 1998, Immunity.

[45]  G. Stark,et al.  Biomolecular interaction analysis of IFN gamma-induced signaling events in whole-cell lysates: prevalence of latent STAT1 in high-molecular weight complexes. , 1998, Growth factors.

[46]  M. Lisanti,et al.  Caveolins, a Family of Scaffolding Proteins for Organizing “Preassembled Signaling Complexes” at the Plasma Membrane* , 1998, The Journal of Biological Chemistry.

[47]  J. Darnell,et al.  Structure of the amino-terminal protein interaction domain of STAT-4. , 1998, Science.

[48]  D. Sedmak,et al.  Human Cytomegalovirus Inhibits Major Histocompatibility Complex Class II Expression By Disruption of the Jak/Stat Pathway , 1998, The Journal of experimental medicine.

[49]  I. Mattaj,et al.  Nucleocytoplasmic transport: the soluble phase. , 1998, Annual review of biochemistry.

[50]  S. Becker,et al.  Three-dimensional structure of the Stat3β homodimer bound to DNA , 1998, Nature.

[51]  Michael P. Brown,et al.  Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses , 1998, Cell.

[52]  B. Chait,et al.  Ser727‐dependent recruitment of MCM5 by Stat1α in IFN‐γ‐induced transcriptional activation , 1998 .

[53]  R. Schreiber,et al.  Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent mice , 1998 .

[54]  P. Heinrich,et al.  Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. , 1998, The Biochemical journal.

[55]  G. Stark,et al.  How cells respond to interferons. , 1998, Annual review of biochemistry.

[56]  S. Akira,et al.  Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice. , 1998, Journal of immunology.

[57]  C. Schindler,et al.  Amino-terminal Signal Transducer and Activator of Transcription (STAT) Domains Regulate Nuclear Translocation and STAT Deactivation* , 1998, The Journal of Biological Chemistry.

[58]  S. Dowdy,et al.  TCR antigen-induced cell death occurs from a late G1 phase cell cycle check point. , 1998, Immunity.

[59]  J. Darnell,et al.  Crystal Structure of a Tyrosine Phosphorylated STAT-1 Dimer Bound to DNA , 1998, Cell.

[60]  B. Williams,et al.  Identification of genes differentially regulated by interferon α, β, or γ using oligonucleotide arrays , 1998 .

[61]  H. Pendeville,et al.  SOCS3 Is Essential in the Regulation of Fetal Liver Erythropoiesis , 1999, Cell.

[62]  Jove,et al.  STAT Proteins and Cancer. , 1999, Cancer control : journal of the Moffitt Cancer Center.

[63]  N. Reich,et al.  Cooperation of the transcriptional coactivators CBP and p300 with Stat6. , 1999, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

[64]  J. Darnell,et al.  The Significance of Tetramerization in Promoter Recruitment by Stat5 , 1999, Molecular and Cellular Biology.

[65]  J. Darnell,et al.  Stat3 as an Oncogene , 1999, Cell.

[66]  H. Lodish,et al.  Fetal Anemia and Apoptosis of Red Cell Progenitors in Stat5a−/−5b−/− Mice A Direct Role for Stat5 in Bcl-XL Induction , 1999, Cell.

[67]  G. Feng,et al.  Shp-2 Tyrosine Phosphatase Functions as a Negative Regulator of the Interferon-Stimulated Jak/STAT Pathway , 1999, Molecular and Cellular Biology.

[68]  Monilola A. Olayioye,et al.  ErbB Receptor-induced Activation of Stat Transcription Factors Is Mediated by Src Tyrosine Kinases* , 1999, The Journal of Biological Chemistry.

[69]  K. Miyazono,et al.  Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300. , 1999, Science.

[70]  L. Ivashkiv,et al.  Inhibition of Interleukin 2 Signaling and Signal Transducer and Activator of Transcription (Stat)5 Activation during T Cell Receptor–Mediated Feedback Inhibition of T Cell Expansion , 1999, The Journal of experimental medicine.

[71]  S. Akira,et al.  Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. , 1999, Immunity.

[72]  J. Ihle,et al.  Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. , 1999, Immunity.

[73]  D. Levy,et al.  Stat Protein Transactivation Domains Recruit p300/CBP through Widely Divergent Sequences* , 1999, The Journal of Biological Chemistry.

[74]  J E Darnell,et al.  A nuclear protein tyrosine phosphatase is required for the inactivation of Stat1. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[75]  N. Perrimon,et al.  Polarity determination in the Drosophila eye: a novel role for unpaired and JAK/STAT signaling. , 1999, Genes & development.

[76]  D. Hilton,et al.  Negative regulation of the JAK/STAT pathway , 1999, BioEssays : news and reviews in molecular, cellular and developmental biology.

[77]  V. Fried,et al.  Cellular Physiology of STAT3: Where’s the Cytoplasmic Monomer?* , 1999, The Journal of Biological Chemistry.

[78]  W. Leonard,et al.  Functional Association of Nmi with Stat5 and Stat1 in IL-2- and IFN γ-Mediated Signaling , 1999, Cell.

[79]  G. Stark,et al.  How Stat1 mediates constitutive gene expression: a complex of unphosphorylated Stat1 and IRF1 supports transcription of the LMP2 gene , 2000, The EMBO journal.

[80]  N. Perrimon,et al.  The roles of the Drosophila JAK/STAT pathway , 2000, Oncogene.

[81]  J. Grandis,et al.  STAT signaling in head and neck cancer , 2000, Oncogene.

[82]  C. Schindler,et al.  A Stat3-interacting protein (StIP1) regulates cytokine signal transduction. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[83]  J. Farrar,et al.  Role of the Stat4 N Domain in Receptor Proximal Tyrosine Phosphorylation , 2000, Molecular and Cellular Biology.

[84]  R. Jove,et al.  Activation of Stat3 preassembled with platelet-derived growth factor β receptors requires Src kinase activity , 2000, Oncogene.

[85]  K. Shuai,et al.  Modulation of STAT signaling by STAT-interacting proteins , 2000, Oncogene.

[86]  R. Roeder,et al.  Transcriptional regulation through Mediator-like coactivators in yeast and metazoan cells. , 2000, Trends in biochemical sciences.

[87]  M. Wilm,et al.  Vesicular stomatitis virus matrix protein inhibits host cell gene expression by targeting the nucleoporin Nup98. , 2000, Molecular cell.

[88]  David E. Levy,et al.  STAT1 Affects Lymphocyte Survival and Proliferation Partially Independent of Its Role Downstream of IFN-γ1 , 2000, The Journal of Immunology.

[89]  David E. Levy,et al.  Distinct Requirements for IFNs and STAT1 in NK Cell Function1 , 2000, The Journal of Immunology.

[90]  M. Tremblay,et al.  The T-cell protein tyrosine phosphatase. , 2000, Seminars in immunology.

[91]  Eun Sug Park,et al.  Involvement of JAK/STAT (Janus kinase/signal transducer and activator of transcription) in the thyrotropin signaling pathway. , 2000, Molecular endocrinology.

[92]  C. Horvath,et al.  STAT proteins and transcriptional responses to extracellular signals. , 2000, Trends in biochemical sciences.

[93]  S. Akira.  Roles of STAT3 defined by tissue-specific gene targeting , 2000, Oncogene.

[94]  U. Vinkemeier,et al.  Nucleocytoplasmic translocation of Stat1 is regulated by a leucine-rich export signal in the coiled-coil domain. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[95]  C. Schindler,et al.  Immune response in Stat2 knockout mice. , 2000, Immunity.

[96]  Roy Garcia,et al.  STATs in oncogenesis , 2000, Oncogene.

[97]  G. Stark,et al.  Complex roles of Stat1 in regulating gene expression , 2000, Oncogene.

[98]  L. Ivashkiv,et al.  Inhibition of IL-2-induced Jak-STAT signaling by glucocorticoids. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[99]  Pavel Kovarik,et al.  Serine phosphorylation of STATs , 2000, Oncogene.

[100]  Kevin M. McBride,et al.  Nuclear export signal located within the DNA‐binding domain of the STAT1transcription factor , 2000, The EMBO journal.

[101]  N. Aoki,et al.  A Cytosolic Protein-tyrosine Phosphatase PTP1B Specifically Dephosphorylates and Deactivates Prolactin-activated STAT5a and STAT5b* , 2000, The Journal of Biological Chemistry.

[102]  Steven M. Holland,et al.  Impairment of Mycobacterial But Not Viral Immunity by a Germline Human STAT1 Mutation , 2001, Science.

[103]  V. Poli,et al.  Essential Role of STAT3 in the Control of the Acute-Phase Response as Revealed by Inducible Gene Inactivation in the Liver , 2001, Molecular and Cellular Biology.

[104]  W. Alexander,et al.  Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3 , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[105]  P. Jackson.  A new RING for SUMO: wrestling transcriptional responses into nuclear bodies with PIAS family E3 SUMO ligases. , 2001, Genes & development.

[106]  T. Hunter,et al.  Oncogenic kinase signalling , 2001, Nature.

[107]  J. Darnell,et al.  Antiviral Response in Cells Containing Stat1 with Heterologous Transactivation Domains , 2001, Journal of Virology.

[108]  M. Lisanti,et al.  The caveolin triad: caveolae biogenesis, cholesterol trafficking, and signal transduction. , 2001, Cytokine & growth factor reviews.

[109]  A. Kiger,et al.  Stem Cell Self-Renewal Specified by JAK-STAT Activation in Response to a Support Cell Cue , 2001, Science.

[110]  R. Schreiber,et al.  IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity , 2001, Nature.

[111]  P. Shankaranarayanan,et al.  Acetylation by Histone Acetyltransferase CREB-binding Protein/p300 of STAT6 Is Required for Transcriptional Activation of the 15-Lipoxygenase-1 Gene* , 2001, The Journal of Biological Chemistry.

[112]  H. Drexler,et al.  Role of Gβ-Subunit in Angiotensin II-Type 1 Receptor Signaling☆ , 2001 .

[113]  D. Hilton,et al.  SOCS Proteins: Negative Regulators of Cytokine Signaling , 2001, Stem cells.

[114]  H. Lodish,et al.  Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts. , 2001, Blood.

[115]  J. Darnell,et al.  A Drosophila PIAS homologue negatively regulates stat92E , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[116]  J. Darnell,et al.  Functional Importance of Stat3 Tetramerization in Activation of the α2-Macroglobulin Gene* , 2001, The Journal of Biological Chemistry.

[117]  G. Barber,et al.  Hepatitis C Virus Nonstructural 5A Protein Induces Interleukin-8, Leading to Partial Inhibition of the Interferon-Induced Antiviral Response , 2001, Journal of Virology.

[118]  M. Runge,et al.  Thrombin Regulates Vascular Smooth Muscle Cell Growth and Heat Shock Proteins via the JAK-STAT Pathway* , 2001, The Journal of Biological Chemistry.

[119]  V. Poli,et al.  Essential Role of STAT3 in the Control of the Acute-Phase Response as Revealed by Inducible Gene Activation in the Liver , 2001, Molecular and Cellular Biology.

[120]  Wei Zhu,et al.  Arginine Methylation of STAT1 Modulates IFNα/β-Induced Transcription , 2001, Cell.

[121]  M. Lisanti,et al.  REMOVED: The caveolin triad: caveolae biogenesis, cholesterol trafficking, and signal transduction , 2001 .

[122]  Stephen Brown,et al.  Identification of the first invertebrate interleukin JAK/STAT receptor, the Drosophila gene domeless , 2001, Current Biology.

[123]  P. Bucher,et al.  DNA Binding Specificity of Different STAT Proteins , 2001, The Journal of Biological Chemistry.

[124]  W. Alexander,et al.  Negative Regulators of Cytokine Signaling , 2001, International journal of hematology.

[125]  H. Lodish,et al.  Ligand-independent oligomerization of cell-surface erythropoietin receptor is mediated by the transmembrane domain , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[126]  E. Matunis,et al.  Control of Stem Cell Self-Renewal in Drosophila Spermatogenesis by JAK-STAT Signaling , 2001, Science.

[127]  A. Usacheva,et al.  The WD Motif-containing Protein Receptor for Activated Protein Kinase C (RACK1) Is Required for Recruitment and Activation of Signal Transducer and Activator of Transcription 1 through the Type I Interferon Receptor* , 2001, The Journal of Biological Chemistry.

[128]  J. Herman,et al.  SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity , 2001, Nature Genetics.

[129]  D. Levy,et al.  The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion. , 2001, Cytokine & growth factor reviews.

[130]  W. Alexander,et al.  The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[131]  D. Garcin,et al.  Longer and Shorter Forms of Sendai Virus C Proteins Play Different Roles in Modulating the Cellular Antiviral Response , 2001, Journal of Virology.

[132]  F. Dong,et al.  The Carboxyl Terminus of the Granulocyte Colony- Stimulating Factor Receptor, Truncated in Patients with Severe Congenital Neutropenia/Acute Myeloid Leukemia, Is Required for SH2-Containing Phosphatase-1 Suppression of Stat Activation1 , 2001, The Journal of Immunology.

[133]  R. Lamb,et al.  The V protein of human parainfluenza virus 2 antagonizes type I interferon responses by destabilizing signal transducer and activator of transcription 2. , 2001, Virology.

[134]  T. Taniguchi,et al.  A weak signal for strong responses: interferon-alpha/beta revisited , 2001, Nature Reviews Molecular Cell Biology.

[135]  L. Kinnunen,et al.  Arginine/Lysine-rich Structural Element Is Involved in Interferon-induced Nuclear Import of STATs* , 2001, The Journal of Biological Chemistry.

[136]  D. Montell,et al.  Paracrine Signaling through the JAK/STAT Pathway Activates Invasive Behavior of Ovarian Epithelial Cells in Drosophila , 2001, Cell.

[137]  J. Ihle,et al.  Reduced lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5. , 2002, Blood.

[138]  D. Levy,et al.  What does Stat3 do? , 2002, The Journal of clinical investigation.

[139]  G. Blobel,et al.  Role of Nucleoporin Induction in Releasing an mRNA Nuclear Export Block , 2002, Science.

[140]  I. Gery,et al.  Suppressors of Cytokine Signaling Proteins Are Differentially Expressed in Th1 and Th2 Cells: Implications for Th Cell Lineage Commitment and Maintenance , 2002, The Journal of Immunology.

[141]  W. Alexander,et al.  SOCS-6 Binds to Insulin Receptor Substrate 4, and Mice Lacking the SOCS-6 Gene Exhibit Mild Growth Retardation , 2002, Molecular and Cellular Biology.

[142]  Daniel Nathans,et al.  Specific Ablation of Stat3β Distorts the Pattern of Stat3-Responsive Gene Expression and Impairs Recovery from Endotoxic Shock , 2002, Cell.

[143]  D. Reinberg,et al.  Human Elongator facilitates RNA polymerase II transcription through chromatin , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[144]  D. Levy,et al.  What does Stat 3 do ? , 2002 .

[145]  George Stark,et al.  Isolation and Characterization of a Human STAT1Gene Regulatory Element , 2002, The Journal of Biological Chemistry.

[146]  L. Kinnunen,et al.  Arginine/Lysine-rich Nuclear Localization Signals Mediate Interactions between Dimeric STATs and Importin α5* , 2002, The Journal of Biological Chemistry.

[147]  Chilakamarti V. Ramana,et al.  Stat1-dependent and -independent pathways in IFN-γ-dependent signaling , 2002 .

[148]  Yu-Rong Fu,et al.  Identification of a Nuclear Stat 1 Protein Tyrosine Phosphatase , 2002 .

[149]  Arginine/lysine-rich NLS mediates interactions between dimeric STATs and importin 5 , 2002 .

[150]  C. Horvath,et al.  Selective STAT Protein Degradation Induced by Paramyxoviruses Requires both STAT1 and STAT2 but Is Independent of Alpha/Beta Interferon Signal Transduction , 2002, Journal of Virology.

[151]  R. DePinho,et al.  STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation. , 2002, Immunity.

[152]  V. Nguyễn,et al.  Stat2 Binding to the Interferon-α Receptor 2 Subunit Is Not Required for Interferon-α Signaling* , 2002, The Journal of Biological Chemistry.

[153]  Young-Bum Kim,et al.  PTP1B regulates leptin signal transduction in vivo. , 2002, Developmental cell.

[154]  G. Beresford,et al.  Kinetics of a Gamma Interferon Response: Expression and Assembly of CIITA Promoter IV and Inhibition by Methylation , 2002, Molecular and Cellular Biology.

[155]  J. Darnell,et al.  Negative regulation of STAT92E by an N-terminally truncated STAT protein derived from an alternative promoter site. , 2002, Genes & development.

[156]  W. Alexander,et al.  Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1) , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[157]  I. Lödige,et al.  Constitutive and IFN‐γ‐induced nuclear import of STAT1 proceed through independent pathways , 2002 .

[158]  A nuclear protein tyrosine phosphatase TC-PTP is a potential negative regulator of the PRL-mediated signaling pathway: dephosphorylation and deactivation of signal transducer and activator of transcription 5a and 5b by TC-PTP in nucleus. , 2002, Molecular endocrinology.

[159]  Qian Zhang,et al.  Multilevel Dysregulation of STAT3 Activation in Anaplastic Lymphoma Kinase-Positive T/Null-Cell Lymphoma1 , 2002, The Journal of Immunology.

[160]  S. Rane,et al.  JAKs, STATs and Src kinases in hematopoiesis , 2002, Oncogene.

[161]  J. ten Hoeve,et al.  Identification of a Nuclear Stat1 Protein Tyrosine Phosphatase , 2002, Molecular and Cellular Biology.

[162]  Edward Yang,et al.  Dissociation Time from DNA Determines Transcriptional Function in a STAT1 Linker Mutant* , 2002, The Journal of Biological Chemistry.

[163]  Kevin M. McBride,et al.  Regulated nuclear import of the STAT1 transcription factor by direct binding of importin‐α , 2002, The EMBO journal.

[164]  N. Bruchovsky,et al.  Activation of the Androgen Receptor N-terminal Domain by Interleukin-6 via MAPK and STAT3 Signal Transduction Pathways* , 2002, The Journal of Biological Chemistry.

[165]  M. Tremblay,et al.  The T Cell Protein Tyrosine Phosphatase Is a Negative Regulator of Janus Family Kinases 1 and 3 , 2002, Current Biology.

[166]  D. Levy,et al.  IFN-Stimulated transcription through a TBP-free acetyltransferase complex escapes viral shutoff , 2002, Nature Cell Biology.