HDL cholesterol levels and weight are the main determinants of subclinical atherosclerosis in the young with type 1 diabetes and suitable glycaemic control

The aim of this study was to evaluate subclinical atherosclerosis and related factors in young type 1 diabetes (T1D) patients and healthy peers. Carotid intima-media thickness (cIMT) and anthropometric/laboratorial data were obtained for 83 T1D patients (mean age 19.5 ± 4.0 years, disease duration 9.8 ± 4.8 years) and for 36 matched healthy subjects. Considering all the participants as one group, male sex (p = 0.008), weight (p = 0.016) and T1D (p < 0.001) were positively associated with a higher cIMT. High-density lipoprotein (HDL) (p = 0.036) was negatively associated with cIMT in T1D. In the male T1D patients, HDL ≤47.5 mg/dL had a sensitivity of 87.5% and specificity of 57% (p = 0.035) in detecting those belonging to a higher cIMT tercile. In conclusion, weight and T1D were associated with increased cIMT. HDL levels ≤47.5 mg/dL were related to a higher cIMT in male T1D patients.

[1]  M. Gomes,et al.  Heterogeneous behavior of lipids according to HbA1c levels undermines the plausibility of metabolic syndrome in type 1 diabetes: data from a nationwide multicenter survey , 2012, Cardiovascular Diabetology.

[2]  L. Cook,et al.  Carotid intima-media thickness determined vascular age and the Framingham Risk Score. , 2011, Critical pathways in cardiology.

[3]  T. Orchard,et al.  High-density lipoprotein cholesterol in diabetes: is higher always better? , 2011, Journal of clinical lipidology.

[4]  Jaimie N. Davis,et al.  Subclinical atherosclerosis in Latino youth: progression of carotid intima-media thickness and its relationship to cardiometabolic risk factors. , 2011, The Journal of pediatrics.

[5]  V. Basevi.  Diagnosis and Classification of Diabetes Mellitus , 2011, Diabetes Care.

[6]  Ronald E. LaPorte,et al.  All-Cause Mortality Trends in a Large Population-Based Cohort With Long-Standing Childhood-Onset Type 1 Diabetes , 2010, Diabetes Care.

[7]  S. Kelsey,et al.  Cause-Specific Mortality Trends in a Large Population-Based Cohort With Long-Standing Childhood-Onset Type 1 Diabetes , 2010, Diabetes.

[8]  K. Dahl-Jørgensen,et al.  Early Signs of Atherosclerosis in Diabetic Children on Intensive Insulin Treatment , 2010, Diabetes Care.

[9]  M. Gomes,et al.  Relationship Between Glycated Hemoglobin and Metabolic Syndrome of Type 1 and Type 2 Diabetes , 2010, Diabetes Care.

[10]  G. Rossi,et al.  Diagnosis and Classification of Diabetes Mellitus The information that follows is based largely on the reports of the Expert Committee on the Diagnosis and Classification of Diabetes (Diabetes Care 20:1183–1197, 1997, and Diabetes Care 26:3160–3167, 2003). , 2008, Diabetes Care.

[11]  Tina Costacou,et al.  Type 1 Diabetes and Coronary Artery Disease Additional information for this article can be found in an online appendix at http://care.diabetesjournals.org. A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances. , 2006, Diabetes Care.

[12]  L. Magalhães,et al.  IV Diretrizes Brasileiras de Hipertensão Arterial , 2004 .

[13]  C. Amodeo,et al.  [IV Brazilian guidelines in arterial hypertension]. , 2004, Arquivos brasileiros de cardiologia.

[14]  V. Fuster,et al.  Prevention Conference V: Beyond secondary prevention: identifying the high-risk patient for primary prevention: noninvasive tests of atherosclerotic burden: Writing Group III. , 2000, Circulation.