Extraordinary Manifestation of Evanescent Wave in Biomedical Application

The idea of the proposed paper is a demonstration of the evanescent wave effect on nano-objects of inorganic and organic (in particular, formed blood elements) origin localized in a biological medium, in the direction perpendicular to the direction of the Pointing vector action. On the one hand, this opens up (illustrates) new possibilities in the optical control of the direction of motion and speed of the studied nanoobjects in a layer of biological fluid. On the other hand, the very choice of objects of this type suggests the possible prospects for their use in biology, medicine, pharmacology, and precision chemistry. So, in particular, gold nanoparticles, being non-toxic to the body, are able to penetrate through the cell biomembranes, accumulate in them, thereby contributing to the diagnosis of the cell state with subsequent optical exposure to them, up to destruction in case of cancer pathologies. The role of red blood cells (RBS) in the body is generally unique and controlling their motion contributes to the complex saturation of tissues with oxygen. The choice of just the evanescent wave is explained by the need for near-surface manipulation of optical energy flows, which is especially important in the situation of studying biological complexes and structures. Exclusive manifestation of the evanescent wave action became possible under specially selected experimental condition of evanescent wave exitation. A total internal reflection was realized at the interface between the prism and a biological medium by a linearly polarized wave with the azimuth of polarization of ±45°. The result of such an excitation mechanism was a complex distribution of the optical flow density, which is accompanied by a change in the energy density both in the longitudinal direction coinciding with the direction of the wave vector and in the transverse direction perpendicular to the wave vector. The paper summarizes the latest theoretically and experimentally obtained results illustrating the rectilinear and rotational motion of investigated objects in a biological environment.

[1]  V. V. Tuchin.  Light scattering study of tissues , 1997 .

[2]  Dmitry A. Zimnyakov,et al.  Polarized microstructure of laser radiation scattered by optically active biotissues , 1999, Correlation Optics.

[3]  Valery V. Tuchin,et al.  Estimation of wavelength dependence of refractive index of collagen fibers of scleral tissue , 2000, European Conference on Biomedical Optics.

[4]  R. Gauthier,et al.  Analysis of the behaviour of erythrocytes in an optical trapping system. , 2000, Optics express.

[5]  Optical anisotropy of fibrous biological tissues: analysis of the influence of structural properties , 2007 .

[6]  A. Katzir,et al.  Fiber-Optic Evanescent Wave Spectroscopy in the Middle Infrared , 2008, Applied spectroscopy.

[7]  S. Mittler,et al.  Waveguide evanescent field fluorescence microscopy: Thin film fluorescence intensities and its application in cell biology , 2008 .

[8]  Valery V. Tuchin,et al.  Dispersion dependence of the optical anisotropy and the degree of depolarization of fibrous tissues , 2010 .

[9]  Franco Cosi,et al.  Optical Microspherical Resonators for Biomedical Sensing , 2011, Sensors.

[10]  O V Angelsky,et al.  Circular motion of particles suspended in a Gaussian beam with circular polarization validates the spin part of the internal energy flow. , 2012, Optics express.

[11]  O V Angelsky,et al.  Orbital rotation without orbital angular momentum: mechanical action of the spin part of the internal energy flow in light beams. , 2011, Optics express.

[12]  O. Maragò,et al.  Evanescent wave optical trapping and transport of micro- and nanoparticles on tapered optical fibers , 2012 .

[13]  Mincheng Zhong,et al.  Trapping red blood cells in living animals using optical tweezers , 2013, Nature Communications.

[14]  E. Cremades,et al.  Origin of slow magnetic relaxation in Kramers ions with non-uniaxial anisotropy , 2014, Nature Communications.

[15]  Franco Nori,et al.  Extraordinary momentum and spin in evanescent waves , 2013, Nature Communications.

[16]  A. Y. Bekshaev,et al.  Direct measurements of the extraordinary optical momentum and transverse spin-dependent force using a nano-cantilever , 2015 .

[17]  C. Yu. Zenkova,et al.  The phase problem solving by the use of optical correlation algorithm for reconstructing phase skeleton of complex optical fields , 2015, Other Conferences.

[18]  Andrea Aiello,et al.  Measuring the transverse spin density of light. , 2014, Physical review letters.

[19]  O V Angelsky,et al.  Influence of evanescent wave on birefringent microplates. , 2017, Optics express.

[20]  F. Capasso,et al.  Elliptical orbits of microspheres in an evanescent field , 2017, Proceedings of the National Academy of Sciences.

[21]  C.,et al.  Optical torques and forces in birefringent microplate , 2017 .

[22]  Oleg Angelsky,et al.  Peculiarities of control of erythrocytes moving in an evanescent field , 2019, Journal of biomedical optics.

[23]  A. P. Maksymyak,et al.  Peculiarities of Energy Circulation in Evanescent Field. Application for Red Blood Cells , 2019, Optical Memory and Neural Networks.