The dopamine D4 receptor: biochemical and signalling properties
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Pieter Rondou | G. Haegeman | K. Van Craenenbroeck | Kathleen Van Craenenbroeck | Guy Haegeman | P. Rondou
[1] P. Goldman-Rakic,et al. D1 dopamine receptors in prefrontal cortex: involvement in working memory , 1991, Science.
[2] J. Palacios,et al. Distribution of 5-ht and Da Receptors in Primate Prefrontal Cortex: Implications for Pathophysiology and Treatment Specifically, It Receives Dopaminergic Efferents from the Ventral Tegmental Area (vta) , 2022 .
[3] R. Lefkowitz,et al. Regulation of G protein-coupled receptor signaling by scaffold proteins. , 2002, Circulation research.
[4] M. Low,et al. Dopamine D4 Receptor-Deficient Mice Display Cortical Hyperexcitability , 2001, The Journal of Neuroscience.
[5] A. Grace,et al. Dopamine-mediated modulation of odour-evoked amygdala potentials during pavlovian conditioning , 2002, Nature.
[6] J. Tallman,et al. I. NGD 94-1: identification of a novel, high-affinity antagonist at the human dopamine D4 receptor. , 1997, The Journal of pharmacology and experimental therapeutics.
[7] J. Zhang,et al. D(4) dopamine receptor differentially regulates Akt/nuclear factor-kappa b and extracellular signal-regulated kinase pathways in D(4)MN9D cells. , 2001, Molecular pharmacology.
[8] Z. Rónai,et al. Genotyping the ‐521C/T functional polymorphism in the promoter region of dopamine D4 receptor (DRD4) gene , 2001, Electrophoresis.
[9] C. Schmauss,et al. Dopamine receptor functions: lessions from knockout mice , 2001 .
[10] P. Goldman-Rakic,et al. Modulation of memory fields by dopamine Dl receptors in prefrontal cortex , 1995, Nature.
[11] H. V. Tol,et al. The dopamine D4 receptors and mechanisms of antipsychotic atypicality , 2003, Progress in Neuro-Psychopharmacology and Biological Psychiatry.
[12] A. S. Bogachuk,et al. Two adjacent cysteine residues in the C‐terminal cytoplasmic fragment of bovine rhodopsin are palmitylated , 1988, FEBS letters.
[13] Min Whan Jung,et al. Plasticity and Memory in the Prefrontal Cortex , 2008, Reviews in the neurosciences.
[14] P. Seeman,et al. Atypical Neuroleptics Have Low Affinity for Dopamine D2 Receptors or Are Selective for D4 Receptors , 1997, Neuropsychopharmacology.
[15] K. Hofmann,et al. Structure and function of proteins in G-protein-coupled signal transfer. , 1996, Biochimica et biophysica acta.
[16] L. Naylor,et al. Investigation of the Role of Conserved Serine Residues in the Long Form of the Rat D2 Dopamine Receptor Using Site‐Directed Mutagenesis , 1996, Journal of neurochemistry.
[17] K. Davis,et al. Dopamine receptor transcript expression in striatum and prefrontal and occipital cortex. Focal abnormalities in orbitofrontal cortex in schizophrenia. , 1997, Archives of general psychiatry.
[18] B. Shastry. Molecular genetics of attention-deficit hyperactivity disorder (ADHD): an update , 2004, Neurochemistry International.
[19] K. Fuxe,et al. Voltage‐dependence of the human dopamine D2 receptor , 2008, Synapse.
[20] D. Donnelly-roberts,et al. Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[21] S. R. Nash,et al. Dopamine receptors: from structure to function. , 1998, Physiological reviews.
[22] E. Gershon,et al. Allelic variation in the D4 dopamine receptor (DRD4) gene does not predict response to clozapine. , 1994, Archives of general psychiatry.
[23] C. Verney,et al. G(olf) and Gs in rat basal ganglia: possible involvement of G(olf) in the coupling of dopamine D1 receptor with adenylyl cyclase , 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.
[24] S. Iversen,et al. Dopamine: 50 years in perspective , 2007, Trends in Neurosciences.
[25] A. Getson,et al. The effects of a selective D4 dopamine receptor antagonist (L-745,870) in acutely psychotic inpatients with schizophrenia. D4 Dopamine Antagonist Group. , 1997, Archives of general psychiatry.
[26] S. Franklin,et al. PNU-96415E, a potential antipsychotic agent with clozapine-like pharmacological properties. , 1997, The Journal of pharmacology and experimental therapeutics.
[27] A. Bonci,et al. Dopamine responsiveness is regulated by targeted sorting of D2 receptors. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[28] M. Caron,et al. Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor. , 1989, The Journal of biological chemistry.
[29] G. Sedvall,et al. A search for association between schizophrenia and dopamine-related alleles , 2005, European Archives of Psychiatry and Clinical Neuroscience.
[30] J. Tallman,et al. II. Localization and characterization of dopamine D4 binding sites in rat and human brain by use of the novel, D4 receptor-selective ligand [3H]NGD 94-1. , 1997, The Journal of pharmacology and experimental therapeutics.
[31] E. Tirelli,et al. Facilitatory effect of the dopamine D4 receptor agonist PD168,077 on memory consolidation of an inhibitory avoidance learned response in C57BL/6J mice , 2003, Behavioural Brain Research.
[32] J. Vincent,et al. Evolution and cell biology of dopamine receptors in vertebrates , 2003, Biology of the cell.
[33] A. Argiolas,et al. PIP3EA and PD‐168077, two selective dopamine D4 receptor agonists, induce penile erection in male rats: site and mechanism of action in the brain , 2006, The European journal of neuroscience.
[34] M. Millan,et al. Differential Actions of Antiparkinson Agents at Multiple Classes of Monoaminergic Receptor. I. A Multivariate Analysis of the Binding Profiles of 14 Drugs at 21 Native and Cloned Human Receptor Subtypes , 2002, Journal of Pharmacology and Experimental Therapeutics.
[35] M. Martres,et al. Dopamine activation of the arachidonic acid cascade as a basis for D1D2 receptor synergism , 1991, Nature.
[36] D. Donnelly-roberts,et al. Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction. , 2004, Journal of medicinal chemistry.
[37] M. Low,et al. Dopamine D4 Receptor-Knock-Out Mice Exhibit Reduced Exploration of Novel Stimuli , 1999, The Journal of Neuroscience.
[38] H. V. Van Tol,et al. Dopamine D4 receptor repeat: analysis of different native and mutant forms of the human and rat genes. , 1994, Molecular pharmacology.
[39] R. Deth,et al. How environmental and genetic factors combine to cause autism: A redox/methylation hypothesis. , 2008, Neurotoxicology.
[40] A. Megens,et al. Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents. , 2005, Journal of medicinal chemistry.
[41] Xuechu Zhen,et al. D4 Dopamine Receptor Differentially Regulates Akt/Nuclear Factor-κB and Extracellular Signal-Regulated Kinase Pathways in D4MN9D Cells , 2001 .
[42] M. Rubinstein,et al. Functional activation by central monoamines of human dopamine D(4) receptor polymorphic variants coupled to GIRK channels in Xenopus oocytes. , 2007, European journal of pharmacology.
[43] P. Marin,et al. GPCR interacting proteins (GIP). , 2004, Pharmacology & therapeutics.
[44] U. R. Chowdhury,et al. Cutting Edge: Stimulation of Dopamine D4 Receptors Induce T Cell Quiescence by Up-Regulating Krüppel-Like Factor-2 Expression through Inhibition of ERK1/ERK2 Phosphorylation1 , 2006, The Journal of Immunology.
[45] K. Kidd,et al. The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus , 1996, Human Genetics.
[46] G. Haegeman,et al. Resistance of the dopamine D4 receptor to agonist-induced internalization and degradation. , 2010, Cellular signalling.
[47] M. Nöthen,et al. Lack of evidence for allelic association between personality traits and the dopamine D4 receptor gene polymorphisms. , 1997, The American journal of psychiatry.
[48] M. Antonelli,et al. Autoradiographic Localization of the Putative D4 Dopamine Receptor in Rat Brain , 1997, Neurochemical Research.
[49] P. Seeman,et al. Dopamine D4 receptors bind inactive (+)-aporphines, suggesting neuroleptic role. Sulpiride not stereoselective. , 1993, European journal of pharmacology.
[50] T. Mamiya,et al. Effects of L‐745,870, a Dopamine D4 Receptor Antagonist, on Naloxone‐Induced Morphine Dependence in Mice , 2004, Annals of the New York Academy of Sciences.
[51] M Linnoila,et al. The association between the dopamine D4 receptor (D4DR) 16 amino acid repeat polymorphism and novelty seeking. , 1996, Molecular psychiatry.
[52] Y. Fukumaki,et al. Cloning and characterization of the 5'-flanking region of the human dopamine D4 receptor gene. , 1997, Biochemical and biophysical research communications.
[53] D. Grandy,et al. Dopamine D4 receptors are heterogeneously distributed in the striosomes/matrix compartments of the striatum , 2002, Journal of neurochemistry.
[54] M. Millan,et al. Noradrenaline and adrenaline are high affinity agonists at dopamine D4 receptors. , 1997, European journal of pharmacology.
[55] B. Sommer,et al. Receptor density as a factor governing the efficacy of the dopamine D4 receptor ligands, L‐745,870 and U‐101958 at human recombinant D4.4 receptors expressed in CHO cells , 1999, British journal of pharmacology.
[56] D. Helmeste,et al. Dopamine D4 receptors. , 2000, Japanese journal of pharmacology.
[57] Marcus R. Munafò,et al. Association of the Dopamine D4 Receptor (DRD4) Gene and Approach-Related Personality Traits: Meta-Analysis and New Data , 2008, Biological Psychiatry.
[58] Catherine Tallon-Baudry,et al. Induced γ-Band Activity during the Delay of a Visual Short-Term Memory Task in Humans , 1998, The Journal of Neuroscience.
[59] L. Chiodo,et al. D2S, D2L, D3, and D4 dopamine receptors couple to a voltage‐dependent potassium current in N18TG2 × mesencephalon hybrid cell (MES‐23.5) via distinct G proteins , 1999, Synapse.
[60] J. Swanson,et al. Association of the dopamine receptor D4 (DRD4) gene with a refined phenotype of attention deficit hyperactivity disorder (ADHD): a family-based approach , 1998, Molecular Psychiatry.
[61] Anna Y. Kuznetsova,et al. A model for modulation of neuronal synchronization by D4 dopamine receptor-mediated phospholipid methylation , 2008, Journal of Computational Neuroscience.
[62] Y. Itoyama,et al. A dopamine receptor antagonist L-745,870 suppresses microglia activation in spinal cord and mitigates the progression in ALS model mice , 2008, Experimental Neurology.
[63] L. Snyder,et al. Selective reconstitution of human D4 dopamine receptor variants with Gi alpha subtypes. , 2000, Biochemistry.
[64] P D Leeson,et al. 3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor. , 1996, Journal of medicinal chemistry.
[65] H. V. Van Tol,et al. Polymorphisms in dopamine receptors: what do they tell us? , 2000, European journal of pharmacology.
[66] H. V. Van Tol,et al. The dopamine D(4) receptor: one decade of research. , 2000, European journal of pharmacology.
[67] M. Millan,et al. S32504, a Novel Naphtoxazine Agonist at Dopamine D3/D2 Receptors: I. Cellular, Electrophysiological, and Neurochemical Profile in Comparison with Ropinirole , 2004, Journal of Pharmacology and Experimental Therapeutics.
[68] J. Slightom,et al. D4 dopamine receptor-mediated signaling events determined in transfected Chinese hamster ovary cells. , 1994, The Journal of biological chemistry.
[69] H. Michel,et al. Glycosylation, palmitoylation, and localization of the human D2S receptor in baculovirus-infected insect cells. , 1996, Biochemistry.
[70] K K Kidd,et al. A hypervariable segment in the human dopamine receptor D4 (DRD4) gene. , 1993, Human molecular genetics.
[71] K. Fuxe,et al. Differential voltage-sensitivity of D2-like dopamine receptors. , 2008, Biochemical and biophysical research communications.
[72] M. Jackson,et al. Dopamine D4 receptor mediated inhibition of potassium current in neurohypophysial nerve terminals. , 1998, The Journal of pharmacology and experimental therapeutics.
[73] R. North,et al. D2, D3, and D4 dopamine receptors couple to G protein-regulated potassium channels in Xenopus oocytes. , 1996, Molecular pharmacology.
[74] R. Rodgers,et al. Dopamine D4 receptor and anxiety: behavioural profiles of clozapine, L-745,870 and L-741,742 in the mouse plus-maze. , 1997, European journal of pharmacology.
[75] D. Middlemiss,et al. Pharmacological characterization of extracellular acidification rate responses in human D2(long), D3 and D4.4 receptors expressed in Chinese hamster ovary cells , 1999, British journal of pharmacology.
[76] T. Pawson,et al. SH3 binding domains in the dopamine D4 receptor. , 1998, Biochemistry.
[77] D. Sibley,et al. Cellular distribution of the rat D4 dopamine receptor protein in the CNS using anti-receptor antisera , 1997, Brain Research.
[78] D. Grandy,et al. Cloning and expression of a rat D2 dopamine receptor cDNA , 1988, Nature.
[79] D2 dopamine receptor stimulation of mitogenesis in transfected Chinese hamster ovary cells: relationship to dopamine stimulation of tyrosine phosphorylations. , 1993, The Journal of pharmacology and experimental therapeutics.
[80] M. Martres,et al. Pharmacology of human dopamine D3 receptor expressed in a mammalian cell line: comparison with D2 receptor. , 1992, European journal of pharmacology.
[81] U. Hacksell,et al. Intrinsic Efficacy of Antipsychotics at Human D2, D3, and D4 Dopamine Receptors: Identification of the Clozapine Metabolite N-Desmethylclozapine as a D2/D3 Partial Agonist , 2005, Journal of Pharmacology and Experimental Therapeutics.
[82] K. Jellinger. Understanding G protein‐coupled receptors and their role in the CNS (Molecular and Cellular Neurobiology) , 2003 .
[83] H. V. Van Tol,et al. Dopamine D2 and D4 receptor ligands: relation to antipsychotic action. , 1998, European journal of pharmacology.
[84] J. M. Kennedy,et al. Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications. , 1998, NIDA research monograph.
[85] P. Seeman,et al. Dopamine D4 receptors elevated in schizophrenia , 1993, Nature.
[86] F. Tarazi,et al. Regional distribution of dopamine D4 receptors in rat forebrain , 1997, Neuroreport.
[87] Susan R. George,et al. Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1 , 1991, Nature.
[88] M. Millan,et al. [3H]S33084: a novel, selective and potent radioligand at cloned, human dopamine D3 receptors , 2000, Naunyn-Schmiedeberg's Archives of Pharmacology.
[89] J. Seamans,et al. The principal features and mechanisms of dopamine modulation in the prefrontal cortex , 2004, Progress in Neurobiology.
[90] U. Hacksell,et al. Pharmacological Characterization of AC-90179 [2-(4-Methoxyphenyl)-N-(4-methyl-benzyl)-N-(1-methyl-piperidin-4-yl)-acetamide Hydrochloride]: A Selective Serotonin 2A Receptor Inverse Agonist , 2004, Journal of Pharmacology and Experimental Therapeutics.
[91] H. Hartman,et al. Iloperidone binding to human and rat dopamine and 5-HT receptors. , 1996, European journal of pharmacology.
[92] Lin He,et al. Meta-analysis shows significant association between dopamine system genes and attention deficit hyperactivity disorder (ADHD). , 2006, Human molecular genetics.
[93] B. Bondy,et al. Identification of dopamine D4 receptor mRNA in circulating human lymphocytes using nested polymerase chain reaction , 1996, Journal of Neuroimmunology.
[94] C. Felder,et al. Dopamine inhibits Na(+)-H+ exchanger activity in renal BBMV by stimulation of adenylate cyclase. , 1990, The American journal of physiology.
[95] N. Lavine,et al. The dopamine D4 receptor activates intracellular platelet-derived growth factor receptor beta to stimulate ERK1/2. , 2010, Cellular signalling.
[96] R. Todd,et al. The rat dopamine D4 receptor: sequence, gene structure, and demonstration of expression in the cardiovascular system. , 1992, The New biologist.
[97] Philip Seeman,et al. Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine , 1991, Nature.
[98] P. Seeman,et al. Antipsychotic drugs which elicit little or no Parkinsonism bind more loosely than dopamine to brain D2 receptors, yet occupy high levels of these receptors , 1998, Molecular Psychiatry.
[99] S. Chaki,et al. A selective dopamine D4 receptor antagonist, NRA0160: a preclinical neuropharmacological profile. , 1999, Life sciences.
[100] J. Swanson,et al. Dopamine D4 receptor gene polymorphism is associated with attention deficit hyperactivity disorder. , 1996, Molecular psychiatry.
[101] Susumu Tonegawa,et al. Dopamine D2 Long Receptor-Deficient Mice Display Alterations in Striatum-Dependent Functions , 2000, The Journal of Neuroscience.
[102] Zhen Yan,et al. Dopamine D4 Receptors Regulate AMPA Receptor Trafficking and Glutamatergic Transmission in GABAergic Interneurons of Prefrontal Cortex , 2009, The Journal of Neuroscience.
[103] J. Smoller,et al. THE NEUROSCIENCE OF ADHD olecular Genetics of Attention-Deficit / Hyperactivity isorder , 2005 .
[104] P. Goldman-Rakic,et al. Dopamine receptor-interacting proteins: the Ca(2+) connection in dopamine signaling. , 2003, Trends in pharmacological sciences.
[105] R. De La Garza,et al. [3H]PNU‐101958, a D4 dopamine receptor probe, accumulates in prefrontal cortex and hippocampus of non‐human primate brain , 2000, Synapse.
[106] G. Milligan,et al. Human D2 and D4 dopamine receptors couple through β γ G-protein subunits to inwardly rectifying K+ channels (GIRK1) in a Xenopus oocyte expression system: selective antagonism by L-741,626 and L-745,870 respectively , 1998, Neuropharmacology.
[107] David E Nichols,et al. WAY 100635 produces discriminative stimulus effects in rats mediated by dopamine D4 receptor activation , 2009, Behavioural pharmacology.
[108] M. Low,et al. Quantitative analysis of the dopamine D4 receptor in the mouse brain , 2000, Journal of neuroscience research.
[109] M. Matsumoto,et al. Full-length cDNA cloning and distribution of human dopamine D4 receptor. , 1995, Brain research. Molecular brain research.
[110] J N Giedd,et al. Lack of an association between a dopamine-4 receptor polymorphism and attention-deficit/hyperactivity disorder: genetic and brain morphometric analyses , 1998, Molecular Psychiatry.
[111] K. Neve,et al. Preferential Interaction between the Dopamine D2 Receptor and Arrestin2 in Neostriatal Neurons , 2004, Molecular Pharmacology.
[112] Bryan L. Roth,et al. WAY-100635 is a potent dopamine D4 receptor agonist , 2006, Psychopharmacology.
[113] Sarah A. J. Reading,et al. Neurobiology of Schizophrenia , 2006, Neuron.
[114] K. Neve,et al. Pivotal role for aspartate-80 in the regulation of dopamine D2 receptor affinity for drugs and inhibition of adenylyl cyclase. , 1991, Molecular pharmacology.
[115] M. Caron,et al. Role of extracellular disulfide-bonded cysteines in the ligand binding function of the beta 2-adrenergic receptor. , 1990, Biochemistry.
[116] D. Pauls. The Genetics of Attention-Deficit/Hyperactivity Disorder , 2005, Biological Psychiatry.
[117] S. Bate,et al. Selective dopamine D4 receptor agonist (A-412997) improves cognitive performance and stimulates motor activity without influencing reward-related behaviour in rat , 2008, Behavioural pharmacology.
[118] H. Akil,et al. Site-directed mutagenesis of the human dopamine D2 receptor. , 1992, European journal of pharmacology.
[119] M. Geyer,et al. RO-10-5824 is a selective dopamine D4 receptor agonist that increases novel object exploration in C57 mice , 2003, Neuropharmacology.
[120] S. Otte,et al. Dopamine D4 receptor signaling in the rat paraventricular hypothalamic nucleus: Evidence of natural coupling involving immediate early gene induction and mitogen activated protein kinase phosphorylation , 2006, Neuropharmacology.
[121] J. A. Chester,et al. Mice Lacking Dopamine D4 Receptors Are Supersensitive to Ethanol, Cocaine, and Methamphetamine , 1997, Cell.
[122] P. Greengard,et al. Distinct roles of dopamine D2L and D2S receptor isoforms in the regulation of protein phosphorylation at presynaptic and postsynaptic sites , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[123] Xin-Yun Huang,et al. When a G protein-coupled receptor does not couple to a G protein. , 2007, Molecular bioSystems.
[124] O. Civelli,et al. Epinephrine and Norepinephrine Act as Potent Agonists at the Recombinant Human Dopamine D4 Receptor , 1997, Journal of neurochemistry.
[125] M. Knowles,et al. Expression and pharmacological characterization of the human D3 dopamine receptor. , 1994, The Journal of pharmacology and experimental therapeutics.
[126] Marc G Caron,et al. Desensitization of G protein-coupled receptors and neuronal functions. , 2004, Annual review of neuroscience.
[127] J. Seamans,et al. Dopamine Receptor Signaling , 2004, Journal of receptor and signal transduction research.
[128] C. Ragan,et al. Schizophrenia and L-745,870, a novel dopamine D4 receptor antagonist. , 1997, Trends in pharmacological sciences.
[129] M. Owen,et al. An update on the genetics of schizophrenia , 2006, Current opinion in psychiatry.
[130] P. Greengard,et al. DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1 , 1984, Nature.
[131] J. Pernier,et al. Induced gamma-band activity during the delay of a visual short-term memory task in humans. , 1998, The Journal of neuroscience : the official journal of the Society for Neuroscience.
[132] C. Schmauss,et al. Dopamine receptor functions: lessons from knockout mice [corrected]. , 2001, Pharmacology & therapeutics.
[133] A. Sidhu,et al. Coupling of dopamine receptor subtypes to multiple and diverse G proteins , 2000, International Journal of Developmental Neuroscience.
[134] D. Grandy,et al. Dopamine Receptor Gene Expression in the Human Medial Temporal Lobe , 1994, Neuropsychopharmacology.
[135] HANS R. BRUNNER. Dopamine-Sensitive Adenyl Cyclase: Possible Role in Synaptic Transmission , 2000 .
[136] D. Sibley,et al. D2 dopamine receptor expression and trafficking is regulated through direct interactions with ZIP , 2008, Journal of neurochemistry.
[137] J. Swanson,et al. Evidence of positive selection acting at the human dopamine receptor D4 gene locus , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[138] J. Girault,et al. DARPP-32: molecular integration of phosphorylation potential , 2008, Cellular and Molecular Life Sciences.
[139] R. Ebstein,et al. Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking , 1996, Nature Genetics.
[140] W. Yao,et al. Dopaminergic signaling in dendritic spines. , 2008, Biochemical pharmacology.
[141] G. Koob. Drugs of abuse: anatomy, pharmacology and function of reward pathways. , 1992, Trends in pharmacological sciences.
[142] N. Lavine,et al. Dopamine D(4) and D(2L) Receptor Stimulation of the Mitogen-Activated Protein Kinase Pathway Is Dependent on trans-Activation of the Platelet-Derived Growth Factor Receptor. , 2001, Molecular pharmacology.
[143] D. Collier,et al. Dopamine D4 receptor subtypes and response to clozapine , 1993, The Lancet.
[144] Zhen Yan,et al. Dopamine D4 Receptors Regulate GABAA Receptor Trafficking via an Actin/Cofilin/Myosin-dependent Mechanism* , 2009, Journal of Biological Chemistry.
[145] K. Neve,et al. Contributions of Conserved Serine Residues to the Interactions of Ligands with Dopamine D2 Receptors , 1992, Journal of Neurochemistry.
[146] E. Malchiodi,et al. Distribution of D4 dopamine receptor in rat brain with sequence-specific antibodies. , 1997, Brain research. Molecular brain research.
[147] T. Heffner,et al. A series of 6- and 7-piperazinyl- and -piperidinylmethylbenzoxazinones with dopamine D4 antagonist activity: discovery of a potential atypical antipsychotic agent. , 1999, Journal of medicinal chemistry.
[148] H. Khorana,et al. Structure and function in rhodopsin: packing of the helices in the transmembrane domain and folding to a tertiary structure in the intradiscal domain are coupled. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[149] A. Graybiel,et al. Activity of striatal neurons reflects dynamic encoding and recoding of procedural memories , 2005, Nature.
[150] R. Roth,et al. Dopamine D4 receptor antagonist reversal of subchronic phencyclidine-induced object retrieval/detour deficits in monkeys , 1999, Psychopharmacology.
[151] T. Arinami,et al. A genetic polymorphism in the promoter region of DRD4 associated with expression and schizophrenia. , 1999, Biochemical and biophysical research communications.
[152] S. Nelson,et al. Evidence that the dopamine D4 receptor is a susceptibility gene in attention deficit hyperactivity disorder , 1998, Molecular Psychiatry.
[153] N. Lavine,et al. G Protein-coupled Receptors Form Stable Complexes with Inwardly Rectifying Potassium Channels and Adenylyl Cyclase* , 2002, The Journal of Biological Chemistry.
[154] K. Neve,et al. Characterization and distribution of [125I]epidepride binding to dopamine D2 receptors in basal ganglia and cortex of human brain. , 1991, The Journal of pharmacology and experimental therapeutics.
[155] Alessandro Usiello,et al. Distinct functions of the two isoforms of dopamine D2 receptors , 2000, Nature.
[156] Michael E Talkowski,et al. A network of dopaminergic gene variations implicated as risk factors for schizophrenia. , 2008, Human molecular genetics.
[157] K. Neve,et al. Short- and long-term heterologous sensitization of adenylate cyclase by D4 dopamine receptors , 1999, Psychopharmacology.
[158] F. Monsma,et al. Development and characterization of antibodies directed against the mouse D4 dopamine receptor , 1998, The European journal of neuroscience.
[159] M. Caron,et al. Differential Regulation of the Dopamine D2and D3 Receptors by G Protein-coupled Receptor Kinases and β-Arrestins* , 2001, The Journal of Biological Chemistry.
[160] Synthesis of potent and selective dopamine D(4) antagonists as candidate radioligands. , 2001, Bioorganic & medicinal chemistry letters.
[161] A. Rivera,et al. Differential regional and cellular distribution of dopamine D2‐like receptors: An immunocytochemical study of subtype‐specific antibodies in rat and human brain , 1998, The Journal of comparative neurology.
[162] M. Millan,et al. [35S]Guanosine-5'-O-(3-thio)triphosphate binding as a measure of efficacy at human recombinant dopamine D4.4 receptors: actions of antiparkinsonian and antipsychotic agents. , 1997, The Journal of pharmacology and experimental therapeutics.
[163] D. Murphy,et al. Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking , 1996, Nature Genetics.
[164] J. Sandell,et al. Carbon-11 pb-12: an attempt to visualize the dopamine d(4) receptor in the primate brain with positron emission tomography. , 2000, Nuclear medicine and biology.
[165] S. Faraone,et al. Dopamine D4 gene 7-repeat allele and attention deficit hyperactivity disorder. , 1999, The American journal of psychiatry.
[166] E. Borrelli,et al. Structure and function of dopamine receptors , 2000, Neuroscience & Biobehavioral Reviews.
[167] S. Tsuji,et al. Lack of association between dopamine D4 receptor gene and schizophrenia. , 1995, American journal of medical genetics.
[168] M. Caron,et al. Characterization of the desensitization properties of five dopamine receptor subtypes and alternatively spliced variants of dopamine D2 and D4 receptors. , 2006, Biochemical and biophysical research communications.
[169] G. Haegeman,et al. BTB Protein KLHL12 Targets the Dopamine D4 Receptor for Ubiquitination by a Cul3-based E3 Ligase* , 2008, Journal of Biological Chemistry.
[170] M. Brockhaus,et al. Development and Characterization of Antibodies Against the N Terminus of the Human Dopamine D4 Receptor , 1997, Journal of neurochemistry.
[171] P. Seeman,et al. Multiple dopamine D4 receptor variants in the human population , 1992, Nature.
[172] P. Goldman-Rakic,et al. Localization of dopamine D4 receptors in GABAergic neurons of the primate brain , 1996, Nature.
[173] K. Livak,et al. Variability of dopamine D4 receptor (DRD4) gene sequence within and among nonhuman primate species. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[174] P. Leeson,et al. Biological profile of L-745,870, a selective antagonist with high affinity for the dopamine D4 receptor. , 1997, The Journal of pharmacology and experimental therapeutics.
[175] H. V. Van Tol,et al. Comparative pharmacological and functional analysis of the human dopamine D4.2 and D4.10 receptor variants. , 1999, Pharmacogenetics.
[176] Paul Greengard,et al. The Neurobiology of Dopamine Signaling , 2004 .
[177] J. Smoller,et al. Molecular Genetics of Attention-Deficit/Hyperactivity Disorder , 2005, Biological Psychiatry.
[178] P. Goldman-Rakic,et al. The role of D1-dopamine receptor in working memory: local injections of dopamine antagonists into the prefrontal cortex of rhesus monkeys performing an oculomotor delayed-response task. , 1994, Journal of neurophysiology.
[179] M. Caron,et al. Phosphorylation and Palmitoylation of the Human D2L Dopamine Receptor in Sf9 Cells , 1994, Journal of neurochemistry.
[180] Graeme Milligan,et al. G Protein Coupling and Ligand Selectivity of the D2L and D3 Dopamine Receptors , 2008, Journal of Pharmacology and Experimental Therapeutics.
[181] B. Orser,et al. A D2 Class Dopamine Receptor Transactivates a Receptor Tyrosine Kinase to Inhibit NMDA Receptor Transmission , 2002, Neuron.
[182] Ping Zhong,et al. Dopamine D4 Receptors Modulate GABAergic Signaling in Pyramidal Neurons of Prefrontal Cortex , 2002, The Journal of Neuroscience.
[183] E. Levin,et al. Ventral hippocampal dopamine D1 and D2 systems and spatial working memory in rats , 1999, Neuroscience.
[184] K. Neve,et al. Dopamine D2 receptor stimulation of mitogen‐activated protein kinases mediated by cell type‐dependent transactivation of receptor tyrosine kinases , 2005, Journal of neurochemistry.
[185] H. V. Van Tol,et al. Folding Efficiency Is Rate-limiting in Dopamine D4 Receptor Biogenesis* , 2005, Journal of Biological Chemistry.
[186] R. Wise,et al. The neurobiology of addiction , 2019, Annals of the New York Academy of Sciences.
[187] S. Dunnett,et al. The influence of environment and experience on neural grafts , 2001, Nature Reviews Neuroscience.
[188] M. von Zastrow,et al. Distinct Dynamin-dependent and -independent Mechanisms Target Structurally Homologous Dopamine Receptors to Different Endocytic Membranes , 1999, The Journal of cell biology.
[189] S. Ferguson. Receptor tyrosine kinase transactivation: fine-tuning synaptic transmission , 2003, Trends in Neurosciences.
[190] A. Arnsten,et al. Toward a New Understanding of Attention-Deficit Hyperactivity Disorder Pathophysiology , 2009, CNS Drugs.
[191] M. Lokhandwala,et al. Dopamine D2 Receptor Activation Causes Mitogenesis via p44/42 Mitogen-Activated Protein Kinase in Opossum Kidney Cells , 2001 .
[192] G. Milligan,et al. Protein-protein interactions at G-protein-coupled receptors. , 2001, Trends in pharmacological sciences.
[193] J. Leysen,et al. Influence of the antipsychotic drug pipamperone on the expression of the dopamine D4 receptor. , 2006, Life sciences.
[194] H. V. Van Tol,et al. Modulation of Intracellular Cyclic AMP Levels by Different Human Dopamine D4 Receptor Variants , 1995, Journal of neurochemistry.
[195] D. Grandy,et al. Molecular diversity of the dopamine receptors. , 1993, Annual review of pharmacology and toxicology.
[196] P S Goldman-Rakic,et al. Layer V neurons bear the majority of mRNAs encoding the five distinct dopamine receptor subtypes in the primate prefrontal cortex , 1998, Synapse.
[197] N. M. Lind,et al. Effects of dopamine D4 receptor antagonist on spontaneous alternation in rats , 2008, Behavioral and Brain Functions.
[198] D. Sibley,et al. New insights into dopaminergic receptor function using antisense and genetically altered animals. , 1999, Annual review of pharmacology and toxicology.
[199] A. Faure,et al. Lesion to the Nigrostriatal Dopamine System Disrupts Stimulus-Response Habit Formation , 2005, The Journal of Neuroscience.
[200] J. Obeso,et al. Levodopa therapy for Parkinson's disease: Challenges and future prospects , 2008, Movement disorders : official journal of the Movement Disorder Society.