Synthesis of [3H]win 35,065-2; A new radioligand for cocaine receptors

Treatment of methyl (-)-3β-phenylnortropane-2β-carboxylate with [3H]CH3I afforded [3H]WIN 35,065-2 with specific activity of 25 Ci/mmol, a new ligand for the cocaine recognition site.

[1]  M. Kuhar,et al.  Cocaine receptors on dopamine transporters are related to self-administration of cocaine. , 1987, Science.

[2]  P. H. Andersen.  Biochemical and Pharmacological Characterization of [3H]GBR 12935 Binding In Vitro to Rat Striatal Membranes: Labeling of the Dopamine Uptake Complex , 1987, Journal of neurochemistry.

[3]  S. Paul,et al.  Characterization of Sodium‐Dependent [3H]GBR‐12935 Binding in Brain: A Radioligand for Selective Labelling of the Dopamine Transport Complex , 1986, Journal of neurochemistry.

[4]  A. Lajtha,et al.  Sodium-independent binding of [3H]cocaine in mouse striatum is serotonin related , 1985, Brain Research.

[5]  S. Snyder,et al.  [3H]mazindol binding associated with neuronal dopamine and norepinephrine uptake sites. , 1984, Molecular pharmacology.

[6]  A. Lajtha,et al.  Reduction of dopamine uptake and cocaine binding in mouse striatum by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. , 1984, European journal of pharmacology.

[7]  A. Lajtha,et al.  A portion of [3H]cocaine binding in brain is associated with serotonergic neurons. , 1983, Molecular pharmacology.

[8]  I. Hanbauer,et al.  Sodium‐Sensitive Cocaine Binding to Rat Striatal Membrane: Possible Relationship to Dopamine Uptake Sites , 1983, Journal of neurochemistry.

[9]  D. Ahern,et al.  (.+-.)-[Methyl-3H and -2H]mianserin. Participants in a dramatic instance of HPLC isotopic fractionation , 1981 .

[10]  A. Lajtha,et al.  Saturable (3H)cocaine binding in central nervous system of mouse. , 1980, Life sciences.

[11]  R. L. Clarke,et al.  Compounds affecting the central nervous system. 4. 3 Beta-phenyltropane-2-carboxylic esters and analogs. , 1973, Journal of medicinal chemistry.