TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy
暂无分享,去创建一个
J. Grutzendler | S. Paul | T. Bird | Wenjie Luo | D. Baddeley | M. Colonna | C. Keene | Yaming Wang | Peng Yuan | Carlo Condello
[1] Jaime Grutzendler,et al. Attenuation of β-Amyloid Deposition and Neurotoxicity by Chemogenetic Modulation of Neural Activity , 2016, The Journal of Neuroscience.
[2] Mariana Vargas-Caballero,et al. Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology , 2016, Brain : a journal of neurology.
[3] S. Younkin,et al. Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)* , 2015, The Journal of Biological Chemistry.
[4] Keith A. Johnson,et al. Modulation of TREM2 by CD33: a protein QTL study integrates Alzheimer loci in human monocytes , 2015, Nature Neuroscience.
[5] O. Korvatska,et al. R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study. , 2015, JAMA neurology.
[6] A. Najafi,et al. Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice , 2015, Journal of Neuroinflammation.
[7] P. De Camilli,et al. Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer’s disease amyloid plaques , 2015, Proceedings of the National Academy of Sciences.
[8] J. Herms,et al. Fibrillar Amyloid Plaque Formation Precedes Microglial Activation , 2015, PloS one.
[9] R. Ransohoff,et al. TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models , 2015, The Journal of experimental medicine.
[10] D. Holtzman,et al. TREM2 lipid sensing sustains microglia response in an Alzheimer’s disease model , 2015, Cell.
[11] F. Edwards,et al. A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology. , 2015, Cell reports.
[12] J. Grutzendler,et al. Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques , 2014, Nature Communications.
[13] L. Lue,et al. TREM2 Protein Expression Changes Correlate with Alzheimer's Disease Neurodegenerative Pathologies in Post‐Mortem Temporal Cortices , 2014, Brain pathology.
[14] B. Vissel,et al. Inconsistencies and Controversies Surrounding the Amyloid Hypothesis of Alzheimer's Disease , 2014, Acta neuropathologica communications.
[15] J. Molinuevo,et al. TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis , 2014, Science Translational Medicine.
[16] A. Goate,et al. Coding variants in TREM2 increase risk for Alzheimer's disease. , 2014, Human molecular genetics.
[17] D. Holtzman,et al. Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2 , 2014, Molecular Neurodegeneration.
[18] J. Herms,et al. In vivo imaging reveals sigmoidal growth kinetic of β-amyloid plaques , 2014, Acta neuropathologica communications.
[19] M. Bullido,et al. Assessing the role of the TREM2 p.R47H variant as a risk factor for Alzheimer's disease and frontotemporal dementia , 2014, Neurobiology of Aging.
[20] Carol J Hirschmugl,et al. Synchrotron FTIR reveals lipid around and within amyloid plaques in transgenic mice and Alzheimer's disease brain. , 2013, The Analyst.
[21] A. Singleton,et al. TREM2 variants in Alzheimer's disease. , 2013, The New England journal of medicine.
[22] A. Hofman,et al. Variant of TREM2 associated with the risk of Alzheimer's disease. , 2013, The New England journal of medicine.
[23] H. Kretzschmar,et al. Amyloid plaque formation precedes dendritic spine loss , 2012, Acta Neuropathologica.
[24] Douglas G. Walker,et al. Postmortem interval effect on RNA and gene expression in human brain tissue , 2011, Cell and Tissue Banking.
[25] Jamaal A Rehman,et al. TLR4 mutation reduces microglial activation, increases Aβ deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's disease , 2011, Journal of Neuroinflammation.
[26] J. Grutzendler,et al. Multicolor time-stamp reveals the dynamics and toxicity of amyloid deposition , 2011, Scientific reports.
[27] J. Grutzendler,et al. CX3CR1 in Microglia Regulates Brain Amyloid Deposition through Selective Protofibrillar Amyloid-β Phagocytosis , 2010, The Journal of Neuroscience.
[28] G. Landreth,et al. The role of microglia in amyloid clearance from the AD brain , 2010, Journal of Neural Transmission.
[29] K. Coggeshall,et al. TREM2- and DAP12-Dependent Activation of PI3K Requires DAP10 and Is Inhibited by SHIP1 , 2010, Science Signaling.
[30] David Baddeley,et al. Visualization of Localization Microscopy Data , 2010, Microscopy and Microanalysis.
[31] G. Landreth,et al. CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar Aβ-Stimulated Microglial Activation , 2009, The Journal of Neuroscience.
[32] D. Holtzman,et al. The Role of Apolipoprotein E in Alzheimer's Disease , 2009, Neuron.
[33] David Baddeley,et al. Light-induced dark states of organic fluochromes enable 30 nm resolution imaging in standard media. , 2009, Biophysical journal.
[34] I. Bechmann,et al. TREM2 is upregulated in amyloid plaque‐associated microglia in aged APP23 transgenic mice , 2008, Glia.
[35] D. Westaway,et al. Dense-core and diffuse Abeta plaques in TgCRND8 mice studied with synchrotron FTIR microspectroscopy. , 2007, Biopolymers.
[36] H. Kettenmann,et al. Microglia: active sensor and versatile effector cells in the normal and pathologic brain , 2007, Nature Neuroscience.
[37] M. Ohno,et al. Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation , 2006, The Journal of Neuroscience.
[38] Hartwig Wolburg,et al. Aβ42‐driven cerebral amyloidosis in transgenic mice reveals early and robust pathology , 2006, EMBO reports.
[39] W. Gan,et al. ATP mediates rapid microglial response to local brain injury in vivo , 2005, Nature Neuroscience.
[40] J. Dietschy,et al. Thematic review series: Brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal Published, JLR Papers in Press, May 16, 2004. DOI 10.1194/jlr.R400004-JLR200 , 2004, Journal of Lipid Research.
[41] K. Moore,et al. CD36 Mediates the Innate Host Response to β-Amyloid , 2003, The Journal of experimental medicine.
[42] M. Colonna. TREMs in the immune system and beyond , 2003, Nature Reviews Immunology.
[43] J. Sutcliffe,et al. Heterogeneous expression of the triggering receptor expressed on myeloid cells‐2 on adult murine microglia , 2002, Journal of neurochemistry.
[44] M. Staufenbiel,et al. 3D-Reconstruction of microglia and amyloid in APP23 transgenic mice: no evidence of intracellular amyloid , 2001, Neurobiology of Aging.
[45] B. Blom,et al. DAP12-deficient mice fail to develop autoimmunity due to impaired antigen priming. , 2000, Immunity.
[46] Leena Peltonen,et al. Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts , 2000, Nature Genetics.
[47] W. B. Stine,et al. The nanometer-scale structure of amyloid-Β visualized by atomic force microscopy , 1996 .
[48] J. Reed,et al. Substitutions of hydrophobic amino acids reduce the amyloidogenicity of Alzheimer's disease beta A4 peptides. , 1992, Journal of molecular biology.
[49] G. Kuperminc,et al. Acknowledgments , 1991, European Journal of Psychology of Education.
[50] Habib Zaidi,et al. Amyloid-β positron emission tomography imaging probes: a critical review. , 2013, Journal of Alzheimer's disease : JAD.
[51] A. Singleton,et al. TREM2 Variants in Alz hei mer's Disease , 2012 .
[52] M. Block,et al. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms , 2007, Nature Reviews Neuroscience.
[53] W. B. Stine,et al. The nanometer-scale structure of amyloid-beta visualized by atomic force microscopy. , 1996, Journal of protein chemistry.