A signature of balancing selection in the region upstream to the human UGT2B4 gene and implications for breast cancer risk

[1]  A. Jayakumar Greenspan’s Basic and Clinical Endocrinology , 2012, The Yale Journal of Biology and Medicine.

[2]  N. Bresolin,et al.  Genetic diversity at endoplasmic reticulum aminopeptidases is maintained by balancing selection and is associated with natural resistance to HIV-1 infection. , 2010, Human molecular genetics.

[3]  Warren W. Kretzschmar,et al.  Balancing Selection Maintains a Form of ERAP2 that Undergoes Nonsense-Mediated Decay and Affects Antigen Presentation , 2010, PLoS genetics.

[4]  N. Bresolin,et al.  Genetic variability in the ACE gene region surrounding the Alu I/D polymorphism is maintained by balancing selection in human populations , 2010, Pharmacogenetics and genomics.

[5]  Jeremiah D. Degenhardt,et al.  Targets of balancing selection in the human genome. , 2009, Molecular biology and evolution.

[6]  N. Bresolin,et al.  A population genetics study of the Familial Mediterranean Fever gene: evidence of balancing selection under an overdominance regime , 2009, Genes and Immunity.

[7]  Yasuhiro Aoki,et al.  Quantitative Analysis of UDP-Glucuronosyltransferase (UGT) 1A and UGT2B Expression Levels in Human Livers , 2009, Drug Metabolism and Disposition.

[8]  Matteo Fumagalli,et al.  Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions , 2009, The Journal of experimental medicine.

[9]  Pablo Librado,et al.  DnaSP v5: a software for comprehensive analysis of DNA polymorphism data , 2009, Bioinform..

[10]  E. R. Meyts,et al.  A common deletion in the uridine diphosphate glucuronyltransferase (UGT) 2B17 gene is a strong determinant of androgen excretion in healthy pubertal boys. , 2009, The Journal of clinical endocrinology and metabolism.

[11]  S. Ohno,et al.  Determination of mRNA Expression of Human UDP-Glucuronosyltransferases and Application for Localization in Various Human Tissues by Real-Time Reverse Transcriptase-Polymerase Chain Reaction , 2009, Drug Metabolism and Disposition.

[12]  N. Bresolin,et al.  The signature of long-standing balancing selection at the human defensin β-1 promoter , 2008, Genome Biology.

[13]  Fengtang Yang,et al.  Adaptive evolution of UGT2B17 copy-number variation. , 2008, American journal of human genetics.

[14]  R. Fujiwara,et al.  Expression of UGT1A and UGT2B mRNA in Human Normal Tissues and Various Cell Lines , 2008, Drug Metabolism and Disposition.

[15]  P. Mackenzie,et al.  Liver-enriched transcription factors and their role in regulating UDP glucuronosyltransferase gene expression. , 2008, Current drug metabolism.

[16]  E. Hollox,et al.  Directional and balancing selection in human beta-defensins , 2008, BMC Evolutionary Biology.

[17]  A. Clark,et al.  Recent and ongoing selection in the human genome , 2007, Nature Reviews Genetics.

[18]  Zhaohui S. Qin,et al.  A second generation human haplotype map of over 3.1 million SNPs , 2007, Nature.

[19]  M. Shimizu,et al.  Molecular evolution and balancing selection in the flavin-containing monooxygenase 3 gene (FMO3) , 2007, Pharmacogenetics and genomics.

[20]  M. Laan,et al.  Haplotype Structure of FSHB, the Beta-Subunit Gene for Fertility-Associated Follicle-Stimulating Hormone: Possible Influence of Balancing Selection , 2007, Annals of human genetics.

[21]  Shameek Biswas,et al.  Genomic insights into positive selection. , 2006, Trends in genetics : TIG.

[22]  P. Green,et al.  Scan of Human Genome Reveals No New Loci Under Ancient Balancing Selection , 2006, Genetics.

[23]  D. Charlesworth Balancing Selection and Its Effects on Sequences in Nearby Genome Regions , 2006, PLoS genetics.

[24]  R. Remmel,et al.  Uridine diphosphoglucuronosyltransferase pharmacogenetics and cancer , 2006, Oncogene.

[25]  J. Pritchard,et al.  A Map of Recent Positive Selection in the Human Genome , 2006, PLoS biology.

[26]  Chung-I Wu,et al.  An ancient balanced polymorphism in a regulatory region of human major histocompatibility complex is retained in Chinese minorities but lost worldwide. , 2006, American journal of human genetics.

[27]  Paul Scheet,et al.  Automating sequence-based detection and genotyping of SNPs from diploid samples , 2006, Nature Genetics.

[28]  M. Satake,et al.  Long-term persistence of both functional and non-functional alleles at the leukocyte immunoglobulin-like receptor A3 (LILRA3) locus suggests balancing selection , 2006, Human Genetics.

[29]  Claes Ohlsson,et al.  Large differences in testosterone excretion in Korean and Swedish men are strongly associated with a UDP-glucuronosyl transferase 2B17 polymorphism. , 2006, The Journal of clinical endocrinology and metabolism.

[30]  Pierre Baldi,et al.  Global landscape of recent inferred Darwinian selection for Homo sapiens , 2006, Proc. Natl. Acad. Sci. USA.

[31]  R. Hudson,et al.  Interrogating multiple aspects of variation in a full resequencing data set to infer human population size changes. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[32]  C. Ober,et al.  Evidence of balancing selection at the HLA-G promoter region. , 2005, Human molecular genetics.

[33]  C. Guillemette,et al.  Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily. , 2005, Pharmacogenetics and genomics.

[34]  W. Xie,et al.  Xenobiotic nuclear receptor-mediated regulation of UDP-glucuronosyl-transferases. , 2005, Current drug metabolism.

[35]  M. Tsuneoka,et al.  Nucleotide Sequence Analyses of Human Complement 6 (C6) Gene Suggest Balancing Selection , 2005, Annals of human genetics.

[36]  C. Guillemette,et al.  Metabolic inactivation of estrogens in breast tissue by UDP-glucuronosyltransferase enzymes: an overview , 2004, Breast Cancer Research.

[37]  C. Ulrich,et al.  UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients , 2004, Breast Cancer Research.

[38]  M. Leppert,et al.  SNP haplotypes and allele frequencies show evidence for disruptive and balancing selection in the human leukocyte receptor complex , 2004, Immunogenetics.

[39]  Michael J Bamshad,et al.  Natural selection and molecular evolution in PTC, a bitter-taste receptor gene. , 2004, American journal of human genetics.

[40]  O. Barbier,et al.  Inactivation of androgens by UDP-glucuronosyltransferase enzymes in humans , 2003, Trends in Endocrinology & Metabolism.

[41]  Peter Donnelly,et al.  A comparison of bayesian methods for haplotype reconstruction from population genotype data. , 2003, American journal of human genetics.

[42]  B. Staels,et al.  Peroxisome Proliferator-activated Receptor α Induces Hepatic Expression of the Human Bile Acid Glucuronidating UDP-glucuronosyltransferase 2B4 Enzyme* , 2003, Journal of Biological Chemistry.

[43]  M. Ratain,et al.  UGT pharmacogenomics: implications for cancer risk and cancer therapeutics. , 2003, Pharmacogenetics.

[44]  B. Staels,et al.  FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity. , 2003, Gastroenterology.

[45]  M. Feldman,et al.  The application of molecular genetic approaches to the study of human evolution , 2003, Nature Genetics.

[46]  M. Shriver,et al.  Interrogating a high-density SNP map for signatures of natural selection. , 2002, Genome research.

[47]  S. Tishkoff,et al.  Evidence for balancing selection from nucleotide sequence analyses of human G6PD. , 2002, American journal of human genetics.

[48]  Pardis C Sabeti,et al.  Detecting recent positive selection in the human genome from haplotype structure , 2002, Nature.

[49]  Eric S. Lander,et al.  Human genome sequence variation and the influence of gene history, mutation and recombination , 2002, Nature Genetics.

[50]  M. Bamshad,et al.  A strong signature of balancing selection in the 5′ cis-regulatory region of CCR5 , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[51]  Richard R. Hudson,et al.  Generating samples under a Wright-Fisher neutral model of genetic variation , 2002, Bioinform..

[52]  M. Daly,et al.  A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms , 2001, Nature.

[53]  T. Key,et al.  Serum oestradiol and breast cancer risk. , 1999, Endocrine-related cancer.

[54]  S. Cummings,et al.  Elevated Serum Estradiol and Testosterone Concentrations Are Associated with a High Risk for Breast Cancer , 1999, Annals of Internal Medicine.

[55]  P. Hedrick,et al.  Strong balancing selection at HLA loci: evidence from segregation in South Amerindian families. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[56]  T. Key,et al.  Endogenous estrogen and postmenopausal breast cancer: a quantitative review , 1997, Cancer Causes & Control.

[57]  Y. Fu,et al.  Statistical tests of neutrality of mutations against population growth, hitchhiking and background selection. , 1997, Genetics.

[58]  D. White Book Review Respiratory Infections: A Scientific Basis for Management Edited by Michael S. Niederman, George A. Sarosi, and Jeffrey Glassroth. 657 pp., illustrated. Philadelphia, W.B. Saunders, 1994. $125. 0-7216-4347-7 , 1994 .

[59]  P. White Disorders of aldosterone biosynthesis and action. , 1994, The New England journal of medicine.

[60]  W. Li,et al.  Statistical tests of neutrality of mutations. , 1993, Genetics.

[61]  M. Blankenstein,et al.  Endogenous oestrogens and androgens in normal and malignant endometrial and mammary tissues. , 1989, European journal of cancer & clinical oncology.

[62]  F. Tajima Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. , 1989, Genetics.

[63]  B. Weir,et al.  ESTIMATING F‐STATISTICS FOR THE ANALYSIS OF POPULATION STRUCTURE , 1984, Evolution; international journal of organic evolution.

[64]  F. Tajima Evolutionary relationship of DNA sequences in finite populations. , 1983, Genetics.

[65]  G. A. Watterson On the number of segregating sites in genetical models without recombination. , 1975, Theoretical population biology.

[66]  S WRIGHT,et al.  Genetical Structure of Populations , 1950, British medical journal.

[67]  N. Bresolin,et al.  Widespread balancing selection and pathogen-driven selection at blood group antigen genes. , 2009, Genome research.

[68]  C. Carlson,et al.  Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. , 2004, American journal of human genetics.

[69]  C. Guillemette Pharmacogenomics of human UDP-glucuronosyltransferase enzymes , 2003, The Pharmacogenomics Journal.

[70]  L. Excoffier,et al.  Molecular analysis of the beta-globin gene cluster in the Niokholo Mandenka population reveals a recent origin of the beta(S) Senegal mutation. , 2002, American journal of human genetics.

[71]  L. Excoffier,et al.  Molecular Analysis of the β-Globin Gene Cluster in the Niokholo Mandenka Population Reveals a Recent Origin of the βS Senegal Mutation , 2002 .

[72]  R. Tukey,et al.  Human UDP-glucuronosyltransferases: metabolism, expression, and disease. , 2000, Annual review of pharmacology and toxicology.

[73]  H. Bandelt,et al.  Median-joining networks for inferring intraspecific phylogenies. , 1999, Molecular biology and evolution.