Ictal hemodynamic changes in late‐onset rasmussen encephalitis

We thank Dr Jellinger for his comments on our work as well as his extensive contributions to the study of cerebral amyloid angiopathy (CAA). Differences between samples drawn from autopsy series of demented individuals and from magnetic resonance imaging (MRI) examination of clinical subjects are perhaps not surprising. A radiological–pathological correlation study has suggested that gradient-echo MRI and histopathological examination may each detect microbleeds missed by the other. Although histopathology remains the “gold standard,” we note several advantages to MRI-based analysis, including the ability to study subjects during life and the ready capacity for correlating anatomic location of hemorrhages across multiple subjects. We also note that in analyzing the spatial clustering of hemorrhages, it is important to account for relative differences in the volume of cerebral cortex in each of the cerebral lobes. Further advances in the in vivo imaging of -amyloid promise still greater insight into the distribution of cerebrovascular amyloid and its consequences.