Tuning Cytokine Receptor Signaling by Reorienting Dimer Geometry with Surrogate Ligands Graphical
暂无分享,去创建一个
Irving L. Weissman | Samuel Demharter | Jacob Piehler | K. Christopher Garcia | Peter O. Krutzik | Peter Minary | Isabelle Plo | I. Weissman | K. Garcia | Rahul Sinha | R. Majeti | P. Minary | J. Piehler | C. Richter | G. Wernig | I. Plo | I. Moraga | T. Wehrman | V. Gryshkova | Wan-Jen Hong | Ravindra Majeti | Rahul Sinha | S. Constantinescu | Gerlinde Wernig | Christian P. Richter | Ignacio Moraga | Stephan Wilmes | Vitalina Gryshkova | Feng Guo | Hyna Fabionar | Tom S. Wehrman | Peter Krutzik | Stefan N. Constantinescu | Samuel Demharter | S. Wilmes | W. Hong | Feng Guo | Hyna Fabionar | P. Krutzik | Ignacio Moraga
[1] M. Waters,et al. In vivo targeting of the growth hormone receptor (GHR) Box1 sequence demonstrates that the GHR does not signal exclusively through JAK2. , 2010, Molecular endocrinology.
[2] Robert M Stroud,et al. Mechanistic Diversity of Cytokine Receptor Signaling Across Cell Membranes , 2004, Science's STKE.
[3] R. Lerner,et al. Selecting agonists from single cells infected with combinatorial antibody libraries. , 2013, Chemistry & biology.
[4] Z. Otwinowski,et al. Processing of X-ray diffraction data collected in oscillation mode. , 1997, Methods in enzymology.
[5] Pavel Kovarik,et al. Serine phosphorylation of STATs , 2000, Oncogene.
[6] Ayalew Tefferi,et al. Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis. , 2010, The New England journal of medicine.
[7] P. Heinrich,et al. Studies on the Interleukin-6-type Cytokine Signal Transducer gp130 Reveal a Novel Mechanism of Receptor Activation by Monoclonal Antibodies* , 2000, The Journal of Biological Chemistry.
[8] D. Shaw,et al. How IGF-1 activates its receptor , 2014, eLife.
[9] Jingsheng Liu,et al. The activation and differential signalling of the growth hormone receptor induced by pGH or anti-idiotypic monoclonal antibodies in primary rat hepatocytes , 2013, Molecular and Cellular Endocrinology.
[10] Mario Cazzola,et al. A gain-of-function mutation of JAK2 in myeloproliferative disorders. , 2005, The New England journal of medicine.
[11] S. Imbeaud,et al. Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours , 2009, Nature.
[12] S. Constantinescu,et al. Active and inactive orientations of the transmembrane and cytosolic domains of the erythropoietin receptor dimer. , 2003, Molecular cell.
[13] W. Vainchenker,et al. A JAK2 mutation in myeloproliferative disorders: pathogenesis and therapeutic and scientific prospects. , 2005, Trends in molecular medicine.
[14] J. Violin,et al. beta-arrestin-biased agonism at the beta2-adrenergic receptor. , 2008, The Journal of biological chemistry.
[15] M. Kawahara,et al. The influence of domain structures on the signal transduction of chimeric receptors derived from the erythropoietin receptor. , 2009, Journal of biochemistry.
[16] A. Sergé,et al. Dynamic multiple-target tracing to probe spatiotemporal cartography of cell membranes , 2008, Nature Methods.
[17] Jian-xin Lin,et al. IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation. , 2011, Current opinion in immunology.
[18] Hans-Peter Kriegel,et al. Density-Based Clustering in Spatial Databases: The Algorithm GDBSCAN and Its Applications , 1998, Data Mining and Knowledge Discovery.
[19] K. Garcia,et al. Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors. , 2005, Science.
[20] R. Levine,et al. X-inactivation-based clonality analysis and quantitative JAK2V617F assessment reveal a strong association between clonality and JAK2V617F in PV but not ET/MMM, and identifies a subset of JAK2V617F-negative ET and MMM patients with clonal hematopoiesis. , 2005, Blood.
[21] J. Tavernier,et al. Dimerization of the Interferon Type I Receptor IFNaR2–2 Is Sufficient for Induction of Interferon Effector Genes but Not for Full Antiviral Activity* , 1999, The Journal of Biological Chemistry.
[22] O. Silvennoinen,et al. Signaling through the hematopoietic cytokine receptors. , 1995, Annual review of immunology.
[23] I. Behrmann,et al. JAK2 mutants (e.g., JAK2V617F) and their importance as drug targets in myeloproliferative neoplasms , 2013, JAK-STAT.
[24] C. Pecquet,et al. Orientation‐specific signalling by thrombopoietin receptor dimers , 2011, The EMBO journal.
[25] A. Plückthun,et al. Bispecific Designed Ankyrin Repeat Proteins (DARPins) Targeting Epidermal Growth Factor Receptor Inhibit A431 Cell Proliferation and Receptor Recycling* , 2011, The Journal of Biological Chemistry.
[26] H. Blau,et al. Structural and Mechanistic Insights into Nerve Growth Factor Interactions with the TrkA and p75 Receptors , 2007, Neuron.
[27] D. Riese. Ligand-based receptor tyrosine kinase partial agonists: new paradigm for cancer drug discovery? , 2011, Expert opinion on drug discovery.
[28] J. Wells,et al. Structure and function of human growth hormone: implications for the hematopoietins. , 1993, Annual review of biophysics and biomolecular structure.
[29] M. Ballinger,et al. Will any dimer do? , 1998, Nature Structural Biology.
[30] Debashis Sahoo,et al. Gene Expression Commons: An Open Platform for Absolute Gene Expression Profiling , 2012, PloS one.
[31] J. Schlessinger,et al. Signaling by Receptor Tyrosine Kinases , 1993 .
[32] M. Ultsch,et al. Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. , 1992, Science.
[33] M. Dottore,et al. The Structure of the GM-CSF Receptor Complex Reveals a Distinct Mode of Cytokine Receptor Activation , 2008, Cell.
[34] G. Bu,et al. Ligand-independent growth hormone receptor dimerization occurs in the endoplasmic reticulum and is required for ubiquitin system-dependent endocytosis , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[35] A. Lim,et al. A diversity of antibody epitopes can induce signaling through the erythropoietin receptor. , 2010, Biochemistry.
[36] J. Piehler,et al. Rapid transfer of transmembrane proteins for single molecule dimerization assays in polymer-supported membranes. , 2014, ACS chemical biology.
[37] K. Christopher Garcia,et al. Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System , 2008, Cell.
[38] R. Lerner,et al. Selection of antibodies that regulate phenotype from intracellular combinatorial antibody libraries , 2012, Proceedings of the National Academy of Sciences.
[39] H. Tsunoda,et al. Effective screening method of agonistic diabodies based on autocrine growth. , 2009, Journal of immunological methods.
[40] D E Koshland,et al. A piston model for transmembrane signaling of the aspartate receptor. , 1999, Science.
[41] Guillermo A. Gomez,et al. Mechanism of Activation of Protein Kinase JAK2 by the Growth Hormone Receptor , 2014, Science.
[42] H. Hieronymus,et al. FAS and NF-κB signalling modulate dependence of lung cancers on mutant EGFR , 2011, Nature.
[43] Airlie J. McCoy,et al. Solving structures of protein complexes by molecular replacement with Phaser , 2006, Acta crystallographica. Section D, Biological crystallography.
[44] R. Williams,et al. Crystal structure of a diabody, a bivalent antibody fragment. , 1994, Structure.
[45] Jamie B. Spangler,et al. Insights into cytokine-receptor interactions from cytokine engineering. , 2015, Annual review of immunology.
[46] J. Bazan,et al. Haemopoietic receptors and helical cytokines. , 1990, Immunology today.
[47] M. Dahan,et al. Self-controlled monofunctionalization of quantum dots for multiplexed protein tracking in live cells. , 2010, Angewandte Chemie.
[48] H. Lodish,et al. The erythropoietin receptor cytosolic juxtamembrane domain contains an essential, precisely oriented, hydrophobic motif. , 2001, Molecular cell.
[49] K. Garcia,et al. Structural snapshots of full-length Jak1, a transmembrane gp130/IL-6/IL-6Rα cytokine receptor complex, and the receptor-Jak1 holocomplex. , 2011, Structure.
[50] I. Wilson,et al. Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation. , 1999, Science.
[51] W. Vainchenker,et al. Differential signalling of NH2-terminal flag-labelled thrombopoietin receptor activated by TPO or anti-FLAG antibodies. , 2004, Cellular signalling.
[52] Wen He,et al. An antagonist peptide–EPO receptor complex suggests that receptor dimerization is not sufficient for activation , 1998, Nature Structural Biology.
[53] W. Windsor,et al. Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor. , 1995, Nature.
[54] A. Plückthun,et al. Structural basis for eliciting a cytotoxic effect in HER2-overexpressing cancer cells via binding to the extracellular domain of HER2. , 2013, Structure.
[55] M. Cristina Cardoso,et al. A Versatile Nanotrap for Biochemical and Functional Studies with Fluorescent Fusion Proteins*S , 2008, Molecular & Cellular Proteomics.
[56] P. Gregersen,et al. Structural biology of shared cytokine receptors. , 2009, Annual review of immunology.
[57] Sandra A. Moore,et al. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. , 2005, Cancer cell.
[58] N. Hynes,et al. Monoclonal antibodies against the extracellular domain of the erbB-2 receptor function as partial ligand agonists. , 1992, The Journal of biological chemistry.
[59] K. Garcia,et al. Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex. , 2003, Science.
[60] M. Waters,et al. An agonist-induced conformational change in the growth hormone receptor determines the choice of signalling pathway , 2008, Nature Cell Biology.
[61] J. Schlessinger,et al. Cell Signaling by Receptor Tyrosine Kinases , 2000, Cell.
[62] H. Miyazaki,et al. Switching constant domains enhances agonist activities of antibodies to a thrombopoietin receptor , 2008, Nature Biotechnology.
[63] M. Babu,et al. Molecular signatures of G-protein-coupled receptors , 2013, Nature.
[64] A. Ferrando,et al. Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia , 2011, Nature Genetics.
[65] V. Pande,et al. Mechanistic and structural insight into the functional dichotomy between interleukin-2 and interleukin-15 , 2012, Nature Immunology.
[66] Peter O. Krutzik,et al. Structural Linkage between Ligand Discrimination and Receptor Activation by Type I Interferons , 2011, Cell.
[67] Robert M. Stroud,et al. Efficiency of signalling through cytokine receptors depends critically on receptor orientation , 1998, Nature.
[68] W. Vainchenker,et al. The JAK2 617V>F mutation triggers erythropoietin hypersensitivity and terminal erythroid amplification in primary cells from patients with polycythemia vera. , 2007, Blood.
[69] A. Yoshimura,et al. Ligand-induced activation of chimeric receptors between the erythropoietin receptor and receptor tyrosine kinases. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[70] Sandra A. Moore,et al. MPLW515L Is a Novel Somatic Activating Mutation in Myelofibrosis with Myeloid Metaplasia , 2006, PLoS medicine.
[71] Stefan N. Constantinescu,et al. The Erythropoietin Receptor: Structure, Activation and Intracellular Signal Transduction , 1999, Trends in Endocrinology & Metabolism.
[72] Enrico A. Stura,et al. Functional Mimicry of a Protein Hormone by a Peptide Agonist: The EPO Receptor Complex at 2.8 Å , 1996, Science.
[73] Joseph Schlessinger,et al. Signal transduction by receptors with tyrosine kinase activity , 1990, Cell.
[74] H. Lodish,et al. The prolactin receptor rescues EpoR-/- erythroid progenitors and replaces EpoR in a synergistic interaction with c-kit. , 1998, Blood.
[75] Peter O. Krutzik,et al. Intracellular phospho‐protein staining techniques for flow cytometry: Monitoring single cell signaling events , 2003, Cytometry. Part A : the journal of the International Society for Analytical Cytology.
[76] H. Lodish,et al. Dimerization by a Cytokine Receptor Is Necessary for Constitutive Activation of JAK2V617F* , 2008, Journal of Biological Chemistry.
[77] S. Schreiber,et al. Dimerization as a regulatory mechanism in signal transduction. , 1998, Annual review of immunology.