A novel BCMA/CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo
暂无分享,去创建一个
K. Anderson | M. Friedrich | B. Rattel | O. Thomas | J. Wahl | Y. Tai | S. Hipp | D. Blanset | P. Deegen | P. Adam
[1] Syed Abbas Ali,et al. T cells expressing an anti-B-cell maturation antigen chimeric antigen receptor cause remissions of multiple myeloma. , 2016, Blood.
[2] N. Munshi,et al. APRIL and BCMA promote human multiple myeloma growth and immunosuppression in the bone marrow microenvironment. , 2016, Blood.
[3] Michael L. Wang,et al. Remissions of Multiple Myeloma during a First-in-Humans Clinical Trial of T Cells Expressing an Anti-B-Cell Maturation Antigen Chimeric Antigen Receptor , 2015 .
[4] João Moura,et al. Chemokine Receptor Expression on Normal Blood CD56+ NK-Cells Elucidates Cell Partners That Comigrate during the Innate and Adaptive Immune Responses and Identifies a Transitional NK-Cell Population , 2015, Journal of immunology research.
[5] K. Anderson,et al. Targeting B-cell maturation antigen in multiple myeloma. , 2015, Immunotherapy.
[6] Jessica Katz,et al. Elotuzumab Therapy for Relapsed or Refractory Multiple Myeloma. , 2015, The New England journal of medicine.
[7] P. Sonneveld,et al. Preclinical and clinical evaluation of elotuzumab, a SLAMF7-targeted humanized monoclonal antibody in development for multiple myeloma , 2015, Expert review of hematology.
[8] Yunxin Chen,et al. Daratumumab and its potential in the treatment of multiple myeloma: overview of the preclinical and clinical development , 2015, Therapeutic advances in hematology.
[9] M. Sanford. Blinatumomab: First Global Approval , 2015, Drugs.
[10] N. Munshi,et al. Novel anti-B-cell maturation antigen antibody-drug conjugate (GSK2857916) selectively induces killing of multiple myeloma. , 2014, Blood.
[11] A. Henn,et al. Preclinical Characterization of AMG 330, a CD3/CD33-Bispecific T-Cell–Engaging Antibody with Potential for Treatment of Acute Myelogenous Leukemia , 2014, Molecular Cancer Therapeutics.
[12] K. Yong,et al. Evaluation Of Bcma As a Therapeutic Target In Multiple Myeloma Using An Antibody-Drug Conjugate , 2013 .
[13] M. Raffeld,et al. B-cell Maturation Antigen Is a Promising Target for Adoptive T-cell Therapy of Multiple Myeloma , 2013, Clinical Cancer Research.
[14] M. Friedrich,et al. Regression of Human Prostate Cancer Xenografts in Mice by AMG 212/BAY2010112, a Novel PSMA/CD3-Bispecific BiTE Antibody Cross-Reactive with Non-Human Primate Antigens , 2012, Molecular Cancer Therapeutics.
[15] J. Crowley,et al. Serum B‐cell maturation antigen is elevated in multiple myeloma and correlates with disease status and survival , 2012, British journal of haematology.
[16] T. Marafioti,et al. APRIL promotes cell-cycle progression in primary multiple myeloma cells: influence of D-type cyclin group and translocation status. , 2011, Blood.
[17] KyungMann Kim,et al. Bone marrow stromal cells from multiple myeloma patients uniquely induce bortezomib resistant NF-κB activity in myeloma cells , 2010, Molecular Cancer.
[18] R. Noelle,et al. The immortality of humoral immunity , 2010, Immunological reviews.
[19] N. Munshi,et al. Functional interaction of plasmacytoid dendritic cells with multiple myeloma cells: a therapeutic target. , 2009, Cancer cell.
[20] P. Kufer,et al. BiTE: Teaching antibodies to engage T-cells for cancer therapy. , 2009, Current opinion in molecular therapeutics.
[21] P. Kufer,et al. The effect of dexamethasone on polyclonal T cell activation and redirected target cell lysis as induced by a CD19/CD3-bispecific single-chain antibody construct , 2007, Cancer Immunology, Immunotherapy.
[22] R. Kimmig,et al. MT110: a novel bispecific single-chain antibody construct with high efficacy in eradicating established tumors. , 2006, Molecular immunology.
[23] Y. Natkunam,et al. Utility of Syndecan-1 (CD138) Expression in the Diagnosis of Undifferentiated Malignant Neoplasms: A Tissue Microarray Study of 1,754 Cases , 2005, Applied immunohistochemistry & molecular morphology : AIMM.
[24] P. Hoffmann,et al. Serial killing of tumor cells by cytotoxic T cells redirected with a CD19‐/CD3‐bispecific single‐chain antibody construct , 2005, International journal of cancer.
[25] K. Tarte,et al. BAFF and APRIL protect myeloma cells from apoptosis induced by IL-6 deprivation and dexamethasone , 2003 .
[26] R. Bargou,et al. T-cell-mediated lysis of B cells induced by a CD19xCD3 bispecific single-chain antibody is perforin dependent and death receptor independent , 2004, Cancer Immunology, Immunotherapy.
[27] B. Harder,et al. Expression of BCMA, TACI, and BAFF-R in multiple myeloma: a mechanism for growth and survival. , 2004, Blood.
[28] R. Bram,et al. BCMA Is Essential for the Survival of Long-lived Bone Marrow Plasma Cells , 2004, The Journal of experimental medicine.
[29] K. Lam,et al. B-Cell Maturation Protein, Which Binds the Tumor Necrosis Factor Family Members BAFF and APRIL, Is Dispensable for Humoral Immune Responses , 2001, Molecular and Cellular Biology.
[30] A. P. Bolliger,et al. Cytological examination and cellular composition of bone marrow in healthy, adult, cynomolgus monkeys (Macaca fascicularis) , 1998, Comparative Haematology International.
[31] M. Dimopoulos,et al. Current treatment landscape for relapsed and/or refractory multiple myeloma , 2015, Nature Reviews Clinical Oncology.