Sleep modulates word-pair learning but not motor sequence learning in healthy older adults

Sleep benefits memory across a range of tasks for young adults. However, remarkably little is known of the role of sleep on memory for healthy older adults. We used 2 tasks, 1 assaying motor skill learning and the other assaying nonmotor/declarative learning, to examine off-line changes in performance in young (20-34 years), middle-aged (35-50 years), and older (51-70 years) adults without disordered sleep. During an initial session, conducted either in the morning or evening, participants learned a motor sequence and a list of word pairs. Memory tests were given twice, 12 and 24 hours after training, allowing us to analyze off-line consolidation after a break that included sleep or normal wake. Sleep-dependent performance changes were reduced in older adults on the motor sequence learning task. In contrast, sleep-dependent performance changes were similar for all 3 age groups on the word pair learning task. Age-related changes in sleep or networks activated during encoding or during sleep may contribute to age-related declines in motor sequence consolidation. Interestingly, these changes do not affect declarative memory.

[1]  J. Born,et al.  Effects of Early and Late Nocturnal Sleep on Declarative and Procedural Memory , 1997, Journal of Cognitive Neuroscience.

[2]  L. Boyd,et al.  Sleep to learn after stroke: Implicit and explicit off-line motor learning , 2009, Neuroscience Letters.

[3]  L. Boyd,et al.  Sleep Enhances Implicit Motor Skill Learning in Individuals Poststroke , 2008, Topics in stroke rehabilitation.

[4]  S. Veeraraghavan,et al.  Measurement of sleep. , 1972, Neurology India.

[5]  A. Rogers,et al.  Reliability of Sleep Diaries for Assessment of Sleep/Wake Patterns , 1993, Nursing research.

[6]  J. Röschke,et al.  Percentile reference charts for selected sleep parameters for 20- to 80-Year-Old healthy subjects from the SIESTA database , 2005 .

[7]  Richard B Ivry,et al.  Age-related decline of sleep-dependent consolidation. , 2007, Learning & memory.

[8]  Jan Born,et al.  Midlife decline in declarative memory consolidation is correlated with a decline in slow wave sleep. , 2007, Learning & memory.

[9]  Morris Moscovitch,et al.  Please Scroll down for Article the Effects of Sleep on Episodic Memory in Older and Younger Adults , 2022 .

[10]  J. Gabrieli,et al.  Insights into the ageing mind: a view from cognitive neuroscience , 2004, Nature Reviews Neuroscience.

[11]  Stefan Fischer,et al.  Developmental Differences in Sleep's Role for Implicit Off-line Learning: Comparing Children with Adults , 2007, Journal of Cognitive Neuroscience.

[12]  Robert Stickgold,et al.  The Sleeping Brain's Influence on Verbal Memory: Boosting Resistance to Interference , 2009, PloS one.

[13]  E. Wamsley,et al.  A daytime nap containing solely non-REM sleep enhances declarative but not procedural memory , 2006, Neurobiology of Learning and Memory.

[14]  Lars Bäckman,et al.  Activation in striatum and medial temporal lobe during sequence learning in younger and older adults: Relations to performance , 2010, NeuroImage.

[15]  Á. Pascual-Leone,et al.  Effect of focal cerebellar lesions on procedural learning in the serial reaction time task , 1998, Experimental Brain Research.

[16]  R. Stickgold.  Sleep-dependent memory consolidation , 2005, Nature.

[17]  Jessica D. Payne,et al.  Memory consolidation, the diurnal rhythm of cortisol, and the nature of dreams: a new hypothesis. , 2010, International review of neurobiology.

[18]  Justin C. Hulbert,et al.  Interfering with Theories of Sleep and Memory: Sleep, Declarative Memory, and Associative Interference , 2006, Current Biology.

[19]  J. Born,et al.  Memory consolidation in human sleep depends on inhibition of glucocorticoid release. , 1999, Neuroreport.

[20]  Á. Pascual-Leone,et al.  Awareness Modifies the Skill-Learning Benefits of Sleep , 2004, Current Biology.

[21]  R. N. Spreng,et al.  Reliable differences in brain activity between young and old adults: A quantitative meta-analysis across multiple cognitive domains , 2010, Neuroscience & Biobehavioral Reviews.

[22]  S Laureys,et al.  Sleeping brain, learning brain. The role of sleep for memory systems , 2001, Neuroreport.

[23]  Susanne Diekelmann,et al.  Sleep in children improves memory performance on declarative but not procedural tasks. , 2008, Learning & memory.

[24]  Christine Bastin,et al.  Sleep Contributes to the Strengthening of Some Memories Over Others, Depending on Hippocampal Activity at Learning , 2011, The Journal of Neuroscience.

[25]  Richard B. Ivry,et al.  Spatial and Temporal Sequence Learning in Patients with Parkinson's Disease or Cerebellar Lesions , 2003, Journal of Cognitive Neuroscience.

[26]  Karolina Janacsek,et al.  Sleep has no critical role in implicit motor sequence learning in young and old adults , 2010, Experimental Brain Research.

[27]  R. Stickgold,et al.  Memory consolidation and reconsolidation: what is the role of sleep? , 2005, Trends in Neurosciences.

[28]  S. Keele,et al.  The cognitive and neural architecture of sequence representation. , 2003, Psychological review.

[29]  F. Gregory Ashby,et al.  The neurobiology of categorization , 2010 .

[30]  R. Stickgold,et al.  Practice with Sleep Makes Perfect Sleep-Dependent Motor Skill Learning , 2002, Neuron.

[31]  Edwin M Robertson,et al.  Off-Line Processing: Reciprocal Interactions between Declarative and Procedural Memories , 2007, The Journal of Neuroscience.

[32]  R. Stickgold,et al.  Sleep, Learning, and Dreams: Off-line Memory Reprocessing , 2001, Science.

[33]  R. Buckner.  Memory and Executive Function in Aging and AD Multiple Factors that Cause Decline and Reserve Factors that Compensate , 2004, Neuron.

[34]  Richard B. Ivry,et al.  Sleep-Dependent Consolidation of Contextual Learning , 2006, Current Biology.

[35]  I. Wilhelm,et al.  The whats and whens of sleep-dependent memory consolidation. , 2009, Sleep medicine reviews.

[36]  C. Stern,et al.  An fMRI Study of the Role of the Medial Temporal Lobe in Implicit and Explicit Sequence Learning , 2003, Neuron.

[37]  M. Tucker,et al.  Enhancement of declarative memory performance following a daytime nap is contingent on strength of initial task acquisition. , 2008, Sleep.

[38]  Daniel B. Willingham,et al.  On the development of procedural knowledge. , 1989, Journal of experimental psychology. Learning, memory, and cognition.

[39]  S. Lea,et al.  The Making of Human Concepts , 2010 .

[40]  M. Nissen,et al.  Attentional requirements of learning: Evidence from performance measures , 1987, Cognitive Psychology.

[41]  Rebecca M. C. Spencer,et al.  Continuous Re-Exposure to Environmental Sound Cues During Sleep Does Not Improve Memory for Semantically Unrelated Word Pairs , 2011, Journal of Cognitive Education and Psychology.

[42]  Daniel J Buysse,et al.  The Pittsburgh sleep quality index: A new instrument for psychiatric practice and research , 1989, Psychiatry Research.

[43]  C. Guilleminault,et al.  Meta-analysis of quantitative sleep parameters from childhood to old age in healthy individuals: developing normative sleep values across the human lifespan. , 2004, Sleep.

[44]  D. Cai,et al.  Sleep selectively enhances hippocampus-dependent memory in mice. , 2009, Behavioral neuroscience.