Common variable immune deficiency in a Pomeranian with Pneumocystis carinii pneumonia

A Pomeranian dog, 1 year- and 8 month-old neutered female, was presented with persistent respiratory distress and recurrent generalized demodicosis. Physical examination revealed cyanosis, rough respiratory sounds, multifocal alopecia and dermal erosions on the dorsal side of the forelimbs, perineal area and skin around the eyes. A severe diffuse interstitial lung pattern was observed on thoracic radiographs. The blood examination revealed neutrophilia and hypoglobulinemia. Serum immunoglobulin concentrations of IgG and IgA were low. Histopathological examination revealed severe diffuse interstitial pneumonia with Pneumocystis carinii infection. Severe lymphoid depletion was observed in the spleen and other organs with lymphoid follicles consisted mainly of CD3-positive T cells and few cells of B-cell lineage. B-cell hypoplasia with subsequent antibody deficiency was suspected.

[1]  C. Weissenbacher-Lang,et al.  Detection of Pneumocystis infections by in situ hybridization in lung samples of Austrian pigs with interstitial pneumonia. , 2013, Medical mycology.

[2]  Koichiro Tamura,et al.  MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. , 2013, Molecular biology and evolution.

[3]  S. Hatama,et al.  Pneumocystis carinii Infection in a domestic goat (Capra hircus domesticus) with multibacillary paratuberculosis. , 2013, The Journal of veterinary medical science.

[4]  K. Warnatz,et al.  Common variable immunodeficiency (CVID): exploring the multiple dimensions of a heterogeneous disease , 2012, Annals of the New York Academy of Sciences.

[5]  J. Thalhammer,et al.  Pax5 immunostaining in paraffin-embedded sections of canine non-Hodgkin lymphoma: a novel canine pan pre-B- and B-cell marker. , 2009, Veterinary immunology and immunopathology.

[6]  Eren,et al.  The EUROclass trial: defining subgroups in common variable immunodeficiency. , 2008, Blood.

[7]  M. Matychak,et al.  Common Variable Immunodeficiency in Horses is Characterized by B Cell Depletion in Primary and Secondary Lymphoid Tissues , 2008, Journal of Clinical Immunology.

[8]  S. Weisbroth.  Pneumocystis: newer knowledge about the biology of this group of organisms in laboratory rats and mice , 2006, Lab Animal.

[9]  S. Swift,et al.  Immunoglobulin deficiency in Cavalier King Charles Spaniels with Pneumocystis pneumonia. , 2006, Journal of veterinary internal medicine.

[10]  K. Gortel.  Update on canine demodicosis. , 2006, The Veterinary clinics of North America. Small animal practice.

[11]  J. Shellito,et al.  Immunity against the opportunistic fungal pathogen Pneumocystis. , 2005, Medical mycology.

[12]  J. Kovacs,et al.  Genetic divergence of the dihydrofolate reductase and dihydropteroate synthase genes in Pneumocystis carinii from 7 different host species. , 2001, The Journal of infectious diseases.

[13]  K. Doi,et al.  Pneumocystis carinii pneumonia in a Cavalier King Charles Spaniel. , 2001, The Journal of veterinary medical science.

[14]  M. Ito,et al.  Immunohistochemical study of Pneumocystis carini infection in pigs: evaluation of Pneumocystis pneumonia and a retrospective investigation , 2000, Veterinary Record.

[15]  R. Lobetti.  Common Variable Immunodeficiency in Miniature Dachshunds Affected with Pneumonocystis Carinii Pneumonia , 2000, Journal of Veterinary Diagnostic Investigation.

[16]  M. Domingo,et al.  Pneumocystis carinii pneumonia in a Yorkshire terrier dog. , 2000, Medical mycology.

[17]  R. Lobetti,et al.  Radiographic aspects of Pneumocystis carinii pneumonia in the miniature Dachshund. , 1998, Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association.

[18]  M. Day.  An immunohistochemical study of the lesions of demodicosis in the dog. , 1997, Journal of comparative pathology.

[19]  S. Saari,et al.  Pneumocystis Carinii Pneumonia in Dogs -a Diagnostic Challenge , 1996, Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc.

[20]  T. Furuta,et al.  Spontaneous Pneumocystis carinii infection in the dog with naturally acquired generalised demodicosis , 1994, Veterinary Record.

[21]  C. Macallister,et al.  Pneumocystis carinii pneumonia in foals. , 1994, Journal of the American Veterinary Medical Association.

[22]  S. Henriksen,et al.  Pneumocystis carinii in Large Domestic Animals in Denmark. A Preliminary Report. , 1989, Acta Veterinaria Scandinavica.

[23]  Henriksen Sa,et al.  Pneumocystis carinii in large domestic animals in Denmark. A preliminary report. , 1989 .