Lack of α-synuclein increases amyloid plaque accumulation in a transgenic mouse model of Alzheimer's disease

[1]  J. Pettegrew,et al.  Interaction between Aβ Peptide and α Synuclein: Molecular Mechanisms in Overlapping Pathology of Alzheimer’s and Parkinson’s in Dementia with Lewy Body Disease , 2006, Neurochemical Research.

[2]  M. Wolfe The γ-Secretase Complex: Membrane-Embedded Proteolytic Ensemble , 2006 .

[3]  Runsheng Wang,et al.  Wild-type Presenilin 1 Protects against Alzheimer Disease Mutation-induced Amyloid Pathology* , 2006, Journal of Biological Chemistry.

[4]  T. C. Dickson,et al.  Alpha-synuclein is upregulated in neurones in response to chronic oxidative stress and is associated with neuroprotection , 2006, Experimental Neurology.

[5]  Thomas C. Südhof,et al.  α-Synuclein Cooperates with CSPα in Preventing Neurodegeneration , 2005, Cell.

[6]  N. Hattori,et al.  A Combinatorial Code for the Interaction of α-Synuclein with Membranes* , 2005, Journal of Biological Chemistry.

[7]  A. Sidhu,et al.  The Role of α‐Synuclein in Both Neuroprotection and Neurodegeneration , 2004 .

[8]  Giuseppe Battaglia,et al.  Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[9]  Robert Edwards,et al.  Lipid Rafts Mediate the Synaptic Localization of α-Synuclein , 2004, The Journal of Neuroscience.

[10]  D. Selkoe,et al.  Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration. , 2003, Annual review of neuroscience.

[11]  L. Petrucelli,et al.  Caught in the Act α-Synuclein Is the Culprit in Parkinson's Disease , 2003, Neuron.

[12]  I. Aoki,et al.  Neuronal accumulation of &agr;- and &bgr;-synucleins in the brain of a GM2 gangliosidosis mouse model , 2003 .

[13]  Richard Paylor,et al.  Synaptic Vesicle Depletion Correlates with Attenuated Synaptic Responses to Prolonged Repetitive Stimulation in Mice Lacking α-Synuclein , 2002, The Journal of Neuroscience.

[14]  V. Lee,et al.  Parkin and the Molecular Pathways of Parkinson's Disease , 2001, Neuron.

[15]  Makoto Hashimoto,et al.  β-Amyloid peptides enhance α-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[16]  E. Masliah,et al.  The role of NAC in amyloidogenesis in Alzheimer's disease. , 2000, The American journal of pathology.

[17]  Heidi Phillips,et al.  Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System , 2000, Neuron.

[18]  K. Ashe,et al.  Plaque-associated α-synuclein (NACP) pathology in aged transgenic mice expressing amyloid precursor protein , 2000, Brain Research.

[19]  Fran Maher,et al.  Non-Aβ Component of Alzheimer's Disease Amyloid (NAC) Revisited: NAC and α-Synuclein Are Not Associated with Aβ Amyloid , 1999 .

[20]  S. Younkin,et al.  Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice , 1996, Science.

[21]  E. Masliah,et al.  Non-A beta component of Alzheimer's disease amyloid (NAC) is amyloidogenic. , 1995, Biochemistry.

[22]  Akihiko Iwai,et al.  The precursor protein of non-Aβ component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system , 1995, Neuron.

[23]  E. Masliah,et al.  Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[24]  G. Auburger,et al.  The role of protein aggregates in neuronal pathology: guilty, innocent, or just trying to help? , 2006, Journal of neural transmission. Supplementum.

[25]  M. Wolfe The gamma-secretase complex: membrane-embedded proteolytic ensemble. , 2006, Biochemistry.

[26]  Udo Rüb,et al.  Vulnerability of cortical neurons to Alzheimer's and Parkinson's diseases. , 2006, Journal of Alzheimer's disease : JAD.

[27]  J. Pettegrew,et al.  Interaction between Abeta peptide and alpha synuclein: molecular mechanisms in overlapping pathology of Alzheimer's and Parkinson's in dementia with Lewy body disease. , 2006, Neurochemical research.

[28]  T. Südhof,et al.  Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration. , 2005, Cell.

[29]  N. Hattori,et al.  A combinatorial code for the interaction of alpha-synuclein with membranes. , 2005, The Journal of biological chemistry.

[30]  A. Sidhu,et al.  The role of alpha-synuclein in both neuroprotection and neurodegeneration. , 2004, Annals of the New York Academy of Sciences.

[31]  R. Edwards,et al.  Lipid rafts mediate the synaptic localization of alpha-synuclein. , 2004, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[32]  I. Aoki,et al.  Neuronal accumulation of alpha- and beta-synucleins in the brain of a GM2 gangliosidosis mouse model. , 2003, Neuroreport.

[33]  L. Petrucelli,et al.  Caught in the act: alpha-synuclein is the culprit in Parkinson's disease. , 2003, Neuron.

[34]  L. Mucke,et al.  beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[35]  K. Ashe,et al.  Plaque-associated alpha-synuclein (NACP) pathology in aged transgenic mice expressing amyloid precursor protein. , 2000, Brain research.

[36]  D. Sulzer,et al.  Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. , 2000, Neuron.

[37]  C. Masters,et al.  Non-Abeta component of Alzheimer's disease amyloid (NAC) revisited. NAC and alpha-synuclein are not associated with Abeta amyloid. , 1999, The American journal of pathology.

[38]  E. Masliah,et al.  Altered presynaptic protein NACP is associated with plaque formation and neurodegeneration in Alzheimer's disease. , 1996, The American journal of pathology.