Molecular basis for the inhibition of human NMPRTase, a novel target for anticancer agents

[1]  J. Stephens,et al.  An update on visfatin/pre-B cell colony-enhancing factor, an ubiquitously expressed, illusive cytokine that is regulated in obesity , 2006, Current opinion in lipidology.

[2]  A. Guse.  Second messenger function and the structure–activity relationship of cyclic adenosine diphosphoribose (cADPR) , 2005, The FEBS journal.

[3]  R. Stevens,et al.  The structure of a eukaryotic nicotinic acid phosphoribosyltransferase reveals structural heterogeneity among type II PRTases. , 2005, Structure.

[4]  A. Vidal-Puig,et al.  Visfatin: the missing link between intra-abdominal obesity and diabetes? , 2005, Trends in molecular medicine.

[5]  Sung-Hou Kim,et al.  Crystal Structure of a Nicotinate Phosphoribosyltransferase from Thermoplasma acidophilum* , 2005, Journal of Biological Chemistry.

[6]  J. Koutcher,et al.  Metabolic Signatures Associated with a NAD Synthesis Inhibitor–Induced Tumor Apoptosis Identified by 1H-Decoupled-31P Magnetic Resonance Spectroscopy , 2005, Clinical Cancer Research.

[7]  R. Huber,et al.  Structures of Escherichia coli NAD Synthetase with Substrates and Products Reveal Mechanistic Rearrangements* , 2005, Journal of Biological Chemistry.

[8]  S. Eom,et al.  Crystal structure of NH3‐dependent NAD+ synthetase from Helicobacter pylori , 2005, Proteins.

[9]  L. Guarente,et al.  Calorie Restriction— the SIR2 Connection , 2005, Cell.

[10]  H. Lodish,et al.  Visfatin: A New Adipokine , 2005, Science.

[11]  M. Matsuda,et al.  Visfatin: A Protein Secreted by Visceral Fat That Mimics the Effects of Insulin , 2005, Science.

[12]  S. Imai,et al.  The NAD Biosynthesis Pathway Mediated by Nicotinamide Phosphoribosyltransferase Regulates Sir2 Activity in Mammalian Cells* , 2004, Journal of Biological Chemistry.

[13]  R. Marmorstein.  Structure and chemistry of the Sir2 family of NAD+-dependent histone/protein deactylases. , 2004, Biochemical Society transactions.

[14]  J. Milbrandt,et al.  Increased Nuclear NAD Biosynthesis and SIRT1 Activation Prevent Axonal Degeneration , 2004, Science.

[15]  Max Hasmann,et al.  FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis. , 2003, Cancer research.

[16]  B. Rattel,et al.  Antiangiogenic potency of FK866/K22.175, a new inhibitor of intracellular NAD biosynthesis, in murine renal cell carcinoma. , 2003, Anticancer research.

[17]  H. Fujisawa,et al.  Growth phase‐dependent changes in the subcellular localization of pre‐B‐cell colony‐enhancing factor 1 , 2003, FEBS letters.

[18]  D. Gigot,et al.  Pre‐B‐cell colony‐enhancing factor, whose expression is up‐regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis , 2002, European journal of immunology.

[19]  J. Arends,et al.  Target validation for genomics using peptide‐specific phage antibodies: A study of five gene products overexpressed in colorectal cancer , 2002, International journal of cancer.

[20]  N. Grishin,et al.  Structure of Human Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase , 2002, The Journal of Biological Chemistry.

[21]  B. Rattel,et al.  WK175, a novel antitumor agent, decreases the intracellular nicotinamide adenine dinucleotide concentration and induces the apoptotic cascade in human leukemia cells. , 2002, Cancer research.

[22]  G Jogl,et al.  COMO: a program for combined molecular replacement. , 2001, Acta crystallographica. Section D, Biological crystallography.

[23]  M. Ziegler.  New functions of a long-known molecule. Emerging roles of NAD in cellular signaling. , 2000, European journal of biochemistry.

[24]  J. Arends,et al.  A profile of differentially expressed genes in primary colorectal cancer using suppression subtractive hybridization , 1999, FEBS letters.

[25]  Russ Miller,et al.  The design and implementation of SnB version 2.0 , 1999 .

[26]  J C Sacchettini,et al.  Crystal structure of quinolinic acid phosphoribosyltransferase from Mmycobacterium tuberculosis: a potential TB drug target. , 1998, Structure.

[27]  R J Read,et al.  Crystallography & NMR system: A new software suite for macromolecular structure determination. , 1998, Acta crystallographica. Section D, Biological crystallography.

[28]  C. Grubmeyer,et al.  Kinetic mechanism of nicotinic acid phosphoribosyltransferase: implications for energy coupling. , 1998, Biochemistry.

[29]  G. Murshudov,et al.  Refinement of macromolecular structures by the maximum-likelihood method. , 1997, Acta crystallographica. Section D, Biological crystallography.

[30]  J C Sacchettini,et al.  A new function for a common fold: the crystal structure of quinolinic acid phosphoribosyltransferase. , 1997, Structure.

[31]  C. Grubmeyer,et al.  Energy coupling in Salmonella typhimurium nicotinic acid phosphoribosyltransferase: identification of His-219 as site of phosphorylation. , 1996, Biochemistry.

[32]  Collaborative Computational,et al.  The CCP4 suite: programs for protein crystallography. , 1994, Acta crystallographica. Section D, Biological crystallography.

[33]  I McNiece,et al.  Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor , 1994, Molecular and cellular biology.

[34]  S V Evans,et al.  SETOR: hardware-lighted three-dimensional solid model representations of macromolecules. , 1993, Journal of molecular graphics.

[35]  W. Hendrickson.  Determination of macromolecular structures from anomalous diffraction of synchrotron radiation. , 1991, Science.

[36]  J. Zou,et al.  Improved methods for building protein models in electron density maps and the location of errors in these models. , 1991, Acta crystallographica. Section A, Foundations of crystallography.

[37]  W A Hendrickson,et al.  Selenomethionyl proteins produced for analysis by multiwavelength anomalous diffraction (MAD): a vehicle for direct determination of three‐dimensional structure. , 1990, The EMBO journal.

[38]  Mike Carson,et al.  Ribbon models of macromolecules , 1987 .

[39]  G. Magni,et al.  Enzymology of NAD+ homeostasis in man , 2003, Cellular and Molecular Life Sciences CMLS.

[40]  Thomas C Terwilliger,et al.  SOLVE and RESOLVE: automated structure solution and density modification. , 2003, Methods in enzymology.

[41]  Z. Otwinowski,et al.  [20] Processing of X-ray diffraction data collected in oscillation mode. , 1997, Methods in enzymology.