Recent Trends in Rapid Environmental Monitoring of Pathogens and Toxicants: Potential of Nanoparticle-Based Biosensor and Applications

Of global concern, environmental pollution adversely affects human health and socioeconomic development. The presence of environmental contaminants, especially bacterial, viral, and parasitic pathogens and their toxins as well as chemical substances, poses serious public health concerns. Nanoparticle-based biosensors are considered as potential tools for rapid, specific, and highly sensitive detection of the analyte of interest (both biotic and abiotic contaminants). In particular, there are several limitations of conventional detection methods for water-borne pathogens due to low concentrations and interference with various enzymatic inhibitors in the environmental samples. The increase of cells to detection levels requires long incubation time. This review describes current state of biosensor nanotechnology, the advantage over conventional detection methods, and the challenges due to testing of environmental samples. The major approach is to use nanoparticles as signal reporter to increase output rather than spending time to increase cell concentrations. Trends in future development of novel detection devices and their advantages over other environmental monitoring methodologies are also discussed.

[1]  Robert Langer,et al.  Magnetic relaxation switch detection of human chorionic gonadotrophin. , 2007, Bioconjugate chemistry.

[2]  John G. Bruno,et al.  Fluorescence Assay Based on Aptamer-Quantum Dot Binding to Bacillus thuringiensis Spores , 2007, Journal of Fluorescence.

[3]  Liguang Xu,et al.  Nanoparticle-based environmental sensors , 2010 .

[4]  Werner Weitschies,et al.  Determination of the magneto-optical relaxation of magnetic nanoparticles as a homogeneous immunoassay. , 2007, Analytical chemistry.

[5]  Antje J. Baeumner,et al.  Design and fabrication of a microfluidic device for near-single cell mRNA isolation using a copper hot embossing master , 2009 .

[6]  Charalambos Kaittanis,et al.  One-step, nanoparticle-mediated bacterial detection with magnetic relaxation. , 2007, Nano letters.

[7]  Jing Zhang,et al.  Carbon nanohorn sensitized electrochemical immunosensor for rapid detection of microcystin-LR. , 2010, Analytical chemistry.

[8]  Tuan Vo-Dinh,et al.  Nanosensing at the single cell level. , 2008, Spectrochimica acta. Part B, Atomic spectroscopy.

[9]  Samuel S. R. Dasary,et al.  Gold nanoparticle based label-free SERS probe for ultrasensitive and selective detection of trinitrotoluene. , 2009, Journal of the American Chemical Society.

[10]  J. Bruno,et al.  Immunomagnetic-electrochemiluminescent detection of Escherichia coli O157 and Salmonella typhimurium in foods and environmental water samples , 1996, Applied and environmental microbiology.

[11]  Won-Bo Shim,et al.  Development and validation of a gold nanoparticle immunochromatographic assay (ICG) for the detection of zearalenone. , 2009, Journal of agricultural and food chemistry.

[12]  N. Kotov,et al.  Multifunctional magnetoplasmonic nanoparticle assemblies for cancer therapy and diagnostics (theranostics). , 2010, Macromolecular rapid communications.

[13]  Anant Kumar Singh,et al.  Selective detection of mercury (II) ion using nonlinear optical properties of gold nanoparticles. , 2008, Journal of the American Chemical Society.

[14]  Xiaogang Liu,et al.  One-step, room temperature, colorimetric detection of mercury (Hg2+) using DNA/nanoparticle conjugates. , 2008, Journal of the American Chemical Society.

[15]  Wei Chen,et al.  Development and validation of an immunochromatographic assay for rapid multi-residues detection of cephems in milk. , 2009, Analytica chimica acta.

[16]  S. Yun,et al.  Characteristics of Nanocomposite ZrO 2 /Al 2 O 3 Films Deposited by Plasma-Enhanced Atomic Layer Deposition , 2007 .

[17]  M S Thakur,et al.  Biosensors in food processing , 2013, Journal of Food Science and Technology.

[18]  Guonan Chen,et al.  Fast colorimetric detection of copper ions using L-cysteine functionalized gold nanoparticles. , 2007, Journal of nanoscience and nanotechnology.

[19]  S. B. Shinde,et al.  Recent trends in in-vitro nanodiagnostics for detection of pathogens. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[20]  J. Bruno,et al.  Immunomagnetic-Electrochemiluminescent Detection of Bacillus anthracis Spores in Soil Matrices , 1996, Applied and environmental microbiology.

[21]  Shihab U. Sobuz,et al.  High throughput multiplex PCR and probe-based detection with Luminex beads for seven intestinal parasites. , 2011, The American journal of tropical medicine and hygiene.

[22]  Yunqing Ma,et al.  Disposable nucleic acid biosensors based on gold nanoparticle probes and lateral flow strip. , 2009, Analytical chemistry.

[23]  Lun Wang,et al.  Using organic nanoparticle fluorescence to determine nitrite in water , 2005, Analytical and bioanalytical chemistry.

[24]  T. H. Rider,et al.  A B Cell-Based Sensor for Rapid Identification of Pathogens , 2003, Science.

[25]  Igor L. Medintz,et al.  Multiplexed toxin analysis using four colors of quantum dot fluororeagents. , 2004, Analytical chemistry.

[26]  A. Baeumner,et al.  Application of a unique server-based oligonucleotide probe selection tool toward a novel biosensor for the detection of Streptococcus pyogenes. , 2007, Biosensors & bioelectronics.

[27]  J Stroka,et al.  Immunoaffinity column clean-up prior to thin-layer chromatography for the determination of aflatoxins in various food matrices. , 2000, Journal of chromatography. A.

[28]  T. Yoshizawa,et al.  In-house direct cELISA for determining aflatoxin B 1 in Thai corn and peanuts , 2003, Food additives and contaminants.

[29]  Y. Ueno,et al.  Simultaneous determination of trichothecene mycotoxins and zearalenone in cereals by gas chromatography-mass spectrometry. , 2000, Journal of chromatography. A.

[30]  E. Alocilja,et al.  Fluorescent bio-barcode DNA assay for the detection of Salmonella enterica serovar Enteritidis. , 2009, Biosensors & bioelectronics.

[31]  S. Hajare,et al.  Development of a radioimmunoassay procedure for aflatoxin B1 measurement. , 2003, Journal of agricultural and food chemistry.

[32]  D. Boyacioğlu,et al.  Comparative study of three different methods for the determination of aflatoxins in tahini. , 2002, Journal of agricultural and food chemistry.

[33]  N. Kotov,et al.  Smart electronic yarns and wearable fabrics for human biomonitoring made by carbon nanotube coating with polyelectrolytes. , 2008, Nano letters.

[34]  F. Yu,et al.  Development of a monoclonal antibody against ochratoxin A and its application in enzyme-linked immunosorbent assay and gold nanoparticle immunochromatographic strip. , 2008, Analytical chemistry.

[35]  Donhee Ham,et al.  Chip–NMR biosensor for detection and molecular analysis of cells , 2008, Nature Medicine.

[36]  Wei Chen,et al.  Rapid and sensitive detection of microcystin by immunosensor based on nuclear magnetic resonance. , 2009, Biosensors & bioelectronics.

[37]  J. Gooding,et al.  Using nanoparticle aggregation to give an ultrasensitive amperometric metal ion sensor , 2009 .

[38]  Zusing Yang,et al.  Synthesis of highly fluorescent gold nanoparticles for sensing mercury(II). , 2007, Angewandte Chemie.

[39]  Christophe A. Marquette,et al.  Microfluidic biochip for chemiluminescent detection of allergen-specific antibodies. , 2008, Biosensors & bioelectronics.

[40]  Zhao-xiang Zhang,et al.  Determination of aflatoxins in high-pigment content samples by matrix solid-phase dispersion and high-performance liquid chromatography. , 2006, Journal of agricultural and food chemistry.

[41]  Wei Chen,et al.  Simultaneous and sensitive determination of multiplex chemical residues based on multicolor quantum dot probes. , 2009, Biosensors & bioelectronics.

[42]  Yan Zhang,et al.  Enzyme-linked immunosorbent assay and colloidal gold immunoassay for ochratoxin A: investigation of analytical conditions and sample matrix on assay performance , 2007, Analytical and bioanalytical chemistry.

[43]  G. Lowry,et al.  Towards a definition of inorganic nanoparticles from an environmental, health and safety perspective. , 2009, Nature nanotechnology.

[44]  Chunsun Zhang,et al.  PCR microfluidic devices for DNA amplification. , 2006, Biotechnology advances.

[45]  Antje J. Baeumner,et al.  Human pathogenic Cryptosporidium species bioanalytical detection method with single oocyst detection capability , 2008, Analytical and bioanalytical chemistry.

[46]  Michel Zuiderwijk,et al.  An amplification-free hybridization-based DNA assay to detect Streptococcus pneumoniae utilizing the up-converting phosphor technology. , 2003, Clinical biochemistry.

[47]  E. Wang,et al.  Label-free colorimetric detection of aqueous mercury ion (Hg2+) using Hg2+-modulated G-quadruplex-based DNAzymes. , 2009, Analytical chemistry.

[48]  F. Busetti,et al.  Occurrence and Removal of Potentially Toxic Metals and Heavy Metals in the Wastewater Treatment Plant of Fusina (Venice, Italy) , 2005 .

[49]  Genhua Wu,et al.  A functionalized gold nanoparticles and Rhodamine 6G based fluorescent sensor for high sensitive and selective detection of mercury(II) in environmental water samples. , 2007, Analytica chimica acta.

[50]  P Delfosse,et al.  Production and characterization of monoclonal antibodies for aflatoxin B1 , 1999, Letters in applied microbiology.

[51]  Yong-jun Zhou,et al.  Evaluation of crude toxin and metabolite produced by Helminthosporium gramineum Rabenh for the control of rice sheath blight in paddy fields , 2007 .

[52]  G. Massolini,et al.  Development and integration of an immunoaffinity monolithic disk for the on-line solid-phase extraction and HPLC determination with fluorescence detection of aflatoxin B1 in aqueous solutions. , 2007, Journal of pharmaceutical and biomedical analysis.

[53]  Xiaohua Huang,et al.  Noble metals on the nanoscale: optical and photothermal properties and some applications in imaging, sensing, biology, and medicine. , 2008, Accounts of chemical research.

[54]  Y. Li,et al.  Gold Nanoparticle‐Based Fluorometric and Colorimetric Sensing of Copper(II) Ions , 2005 .

[55]  Da Xing,et al.  Miniaturized PCR chips for nucleic acid amplification and analysis: latest advances and future trends , 2007, Nucleic acids research.

[56]  Ji-Young Kim,et al.  Development of immunochromatography strip-test using nanocolloidal gold-antibody probe for the rapid detection of aflatoxin B1 in grain and feed samples. , 2007, Journal of microbiology and biotechnology.

[57]  Chih-Ching Huang,et al.  Selective gold-nanoparticle-based "turn-on" fluorescent sensors for detection of mercury(II) in aqueous solution. , 2006, Analytical chemistry.

[58]  Antje J Baeumner,et al.  Electrochemical microfluidic biosensor for the detection of nucleic acid sequences. , 2006, Lab on a chip.

[59]  S. P. Anthony,et al.  Selective colorimetric sensing of toxic metal cations by green synthesized silver nanoparticles over a wide pH range , 2013 .

[60]  A. Berg,et al.  Micro Total Analysis Systems , 1995 .

[61]  I. Willner,et al.  Multiplexed analysis of Hg2+ and Ag+ ions by nucleic acid functionalized CdSe/ZnS quantum dots and their use for logic gate operations. , 2009, Angewandte Chemie.

[62]  Guodong Liu,et al.  Aptamer-functionalized gold nanoparticles as probes in a dry-reagent strip biosensor for protein analysis. , 2009, Analytical chemistry.

[63]  Antje J. Baeumner,et al.  Biosensors for the detection of waterborne pathogens , 2011, Analytical and Bioanalytical Chemistry.

[64]  H. John Crabtree,et al.  Microfabricated device for DNA and RNA amplification by continuous-flow polymerase chain reaction and reverse transcription-polymerase chain reaction with cycle number selection. , 2003, Analytical chemistry.

[65]  K. H. Nealson,et al.  Quantum Dots as Strain- and Metabolism-Specific Microbiological Labels , 2003, Applied and Environmental Microbiology.

[66]  Chad A. Mirkin,et al.  Colorimetric nitrite and nitrate detection with gold nanoparticle probes and kinetic end points. , 2009, Journal of the American Chemical Society.

[67]  Richard A Montagna,et al.  Microfluidic biosensor for the serotype-specific detection of dengue virus RNA. , 2005, Analytical chemistry.

[68]  Peter J. Asiello,et al.  Miniaturized isothermal nucleic acid amplification, a review. , 2011, Lab on a chip.

[69]  Darwin R. Reyes,et al.  Micro total analysis systems. 1. Introduction, theory, and technology. , 2002, Analytical chemistry.

[70]  M. Velasco-Garcia,et al.  Optical biosensors for probing at the cellular level: a review of recent progress and future prospects. , 2009, Seminars in cell & developmental biology.

[71]  L. D. Stephenson,et al.  Quantum dot-antibody and aptamer conjugates shift fluorescence upon binding bacteria. , 2004, Biochemical and biophysical research communications.

[72]  Robert Palazzolo,et al.  Single-coil, multisample, proton relaxation method for magnetic relaxation switch assays. , 2008, Analytical chemistry.

[73]  Ralph Weissleder,et al.  Continuous analyte sensing with magnetic nanoswitches. , 2006, Small.

[74]  R. Ocampo-Pérez,et al.  Adsorption of Fluoride from Water Solution on Bone Char , 2007 .

[75]  P. Tuitemwong,et al.  Facile and sensitive epifluorescent silica nanoparticles for the rapid screening of EHEC , 2013 .

[76]  J. Jang,et al.  Enhanced antibacterial activity of silver/polyrhodanine-composite-decorated silica nanoparticles. , 2013, ACS applied materials & interfaces.

[77]  Bing Xu,et al.  Multifunctional magnetic nanoparticles: design, synthesis, and biomedical applications. , 2009, Accounts of chemical research.

[78]  J. Kiel,et al.  Use of magnetic beads in selection and detection of biotoxin aptamers by electrochemiluminescence and enzymatic methods. , 2002, BioTechniques.

[79]  Yanbin Li,et al.  Quantum dot biolabeling coupled with immunomagnetic separation for detection of Escherichia coli O157:H7. , 2004, Analytical chemistry.

[80]  Liguang Xu,et al.  Side-by-side and end-to-end gold nanorod assemblies for environmental toxin sensing. , 2010, Angewandte Chemie.

[81]  Prashant K. Jain,et al.  Noble Metals on the Nanoscale: Optical and Photothermal Properties and Some Applications in Imaging, Sensing, Biology, and Medicine , 2009 .

[82]  S. Santra,et al.  Emerging nanotechnology-based strategies for the identification of microbial pathogenesis. , 2010, Advanced drug delivery reviews.

[83]  G. S. Wilson,et al.  Biosensors : fundamentals and applications , 1987 .

[84]  Yasuo Seto,et al.  A novel sugar-probe biosensor for the deadly plant proteinous toxin, ricin. , 2008, Biosensors & bioelectronics.

[85]  David Dyjack,et al.  The Aqueous Solution. , 2015, Journal of environmental health.

[86]  H. Tanke,et al.  Detection of cell and tissue surface antigens using up-converting phosphors: a new reporter technology. , 1999, Analytical biochemistry.

[87]  Hiroaki Misawa,et al.  A heater-integrated transparent microchannel chip for continuous-flow PCR , 2002 .

[88]  I. Kennedy,et al.  A rapid aflatoxin B1 ELISA: development and validation with reduced matrix effects for peanuts, corn, pistachio, and Soybeans. , 2004, Journal of agricultural and food chemistry.

[89]  H Tanke,et al.  Use of up-converting phosphor reporters in lateral-flow assays to detect specific nucleic acid sequences: a rapid, sensitive DNA test to identify human papillomavirus type 16 infection. , 2001, Clinical chemistry.

[90]  Jinwoo Cheon,et al.  Synergistically Integrated Nanoparticles as Multimodal Probes for Nanobiotechnology , 2009 .

[91]  N. Kotov,et al.  Simple, rapid, sensitive, and versatile SWNT-paper sensor for environmental toxin detection competitive with ELISA. , 2009, Nano letters (Print).

[92]  Cortis K. Cooper,et al.  Natural seepage of crude oil into the marine environment , 2001 .

[93]  Peng Wu,et al.  Chemically immobilized T4-bacteriophage for specific Escherichia coli detection using surface plasmon resonance. , 2011, The Analyst.

[94]  Paresh Chandra Ray,et al.  Gold Nanorod Based Selective Identification of Escherichia coli Bacteria Using Two-Photon Rayleigh Scattering Spectroscopy. , 2009, ACS nano.