CLÍNICA E TRATAMENTO DAS INFECÇÕES PELOS VÍRUS Herpes Símplex TIPO 1 E 2

As infeccoes pelos virus herpes simplex sao conhecidas da raca humana desde a antiguidade. Estes virus sao responsaveis por uma gama de infeccoes que vao desde erupcoes cutâneas ate quadros graves de encefalite. Atualmente, um antiviral especifico para estes virus, o aciclovir, esta disponivel para o tratamento destas infeccoes. Nesta revisao, o uso do aciclovir e discutido em relacao as diversas manifestacoes da infeccao herpetica.

[1]  J. Zeh,et al.  Virologic characteristics of subclinical and symptomatic genital herpes infections. , 1995, The New England journal of medicine.

[2]  B. Roizman,et al.  Herpes simplex genes: the blueprint of a successful human pathogen. , 1994, Trends in genetics : TIG.

[3]  L. Corey,et al.  Risk Factors for the Sexual Transmission of Genital Herpes , 1992, Annals of Internal Medicine.

[4]  C. Crumpacker,et al.  A controlled trial comparing foscarnet with vidarabine for acyclovir-resistant mucocutaneous herpes simplex in the acquired immunodeficiency syndrome. The AIDS Clinical Trials Group. , 1991, The New England journal of medicine.

[5]  L. Corey,et al.  Neonatal herpes simplex virus infection in relation to asymptomatic maternal infection at the time of labor. , 1991, The New England journal of medicine.

[6]  D. Powell,et al.  Predictors of morbidity and mortality in neonates with herpes simplex virus infections , 1991, The New England journal of medicine.

[7]  D. Powell,et al.  A controlled trial comparing vidarabine with acyclovir in neonatal herpes simplex virus infection. Infectious Diseases Collaborative Antiviral Study Group. , 1991, The New England journal of medicine.

[8]  H. Otsuka,et al.  Herpes simplex virus type 2 meningoencephalitis resistant to acyclovir in a patient with AIDS. , 1990, The Journal of infectious diseases.

[9]  H. Balfour,et al.  Herpes Simplex Virus Resistant to Acyclovir: A Study in a Tertiary Care Center , 1990 .

[10]  K. Tyler,et al.  Progressive esophagitis from acyclovir-resistant herpes simplex. Clinical roles for DNA polymerase mutants and viral heterogeneity? , 1989, Annals of internal medicine.

[11]  C. Crumpacker,et al.  Acyclovir-resistant herpes simplex virus infections in patients with the acquired immunodeficiency syndrome. , 1989, The New England journal of medicine.

[12]  G. Høvding.  A comparison between acyclovir and trifluorothymidine ophthalmic ointment in the treatment of epithelial dendritic keratitis , 1989, Acta ophthalmologica.

[13]  E. Andrews,et al.  Acyclovir in Pregnancy Registry. An observational epidemiologic approach. , 1988, The American journal of medicine.

[14]  S. Soong,et al.  Changing presentation of herpes simplex virus infection in neonates. , 1988, The Journal of infectious diseases.

[15]  C. Wilfert,et al.  Herpes simplex virus encephalitis in children: analysis of cerebrospinal fluid and progressive neurodevelopmental deterioration. , 1986, The Journal of infectious diseases.

[16]  R. Schooley,et al.  Vidarabine versus acyclovir therapy in herpes simplex encephalitis. , 1986, The New England journal of medicine.

[17]  J. Mulholland,et al.  Severe but reversible neurotoxicity from acyclovir. , 1984, Annals of internal medicine.

[18]  K. Holmes,et al.  Genital herpes simplex virus infections: clinical manifestations, course, and complications. , 1983, Annals of internal medicine.

[19]  L. Corey.  The diagnosis and treatment of genital herpes. , 1982, JAMA.

[20]  G. Krueger,et al.  The natural history of recurrent herpes simplex labialis: implications for antiviral therapy. , 1977, The New England journal of medicine.