Low expression of Abelson interactor-1 is linked to acquired drug resistance in Bcr-Abl induced leukemia

[1]  M. Loh,et al.  Integrin alpha4 blockade sensitizes drug resistant pre-B acute lymphoblastic leukemia to chemotherapy. , 2013, Blood.

[2]  M. Konopleva,et al.  The Bone Marrow Microenvironment as Niche Retreats for Hematopoietic and Leukemic Stem Cells , 2013, Advances in hematology.

[3]  D. Campana,et al.  Microenvironmental protection of CML stem and progenitor cells from tyrosine kinase inhibitors through N-cadherin and Wnt-β-catenin signaling. , 2012, Blood.

[4]  D. Scadden,et al.  The stem cell niche: tissue physiology at a single cell level. , 2012, The Journal of clinical investigation.

[5]  I. Ben-Sahra,et al.  Imatinib triggers mesenchymal-like conversion of CML cells associated with increased aggressiveness. , 2012, Journal of molecular cell biology.

[6]  Charalampos G. Kalodimos,et al.  Domain organization differences explain Bcr-Abl’s preference for CrkL over CrkII , 2012, Nature chemical biology.

[7]  D. Scadden,et al.  The haematopoietic stem cell niche at a glance , 2011, Journal of Cell Science.

[8]  C. Eckert,et al.  High VLA-4 expression is associated with adverse outcome and distinct gene expression changes in childhood B-cell precursor acute lymphoblastic leukemia at first relapse , 2011, Haematologica.

[9]  A. Bennaceur-Griscelli,et al.  Leukemic stem cell persistence in chronic myeloid leukemia patients with sustained undetectable molecular residual disease. , 2011, Blood.

[10]  Susan Branford,et al.  BCR–ABL Transcript Dynamics Support the Hypothesis That Leukemic Stem Cells Are Reduced during Imatinib Treatment , 2011, Clinical Cancer Research.

[11]  K. Anderson,et al.  Essential role for Abi1 in embryonic survival and WAVE2 complex integrity , 2011, Proceedings of the National Academy of Sciences.

[12]  M. Konopleva,et al.  Leukemia stem cells and microenvironment: biology and therapeutic targeting. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[13]  B. Druker,et al.  Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity. , 2011, The Journal of clinical investigation.

[14]  Jacob R. Haling,et al.  Abl-interactor-1 (Abi1) has a role in cardiovascular and placental development and is a binding partner of the α4 integrin , 2010, Proceedings of the National Academy of Sciences.

[15]  P. Defilippi,et al.  Integrin signalling adaptors: not only figurants in the cancer story , 2010, Nature Reviews Cancer.

[16]  C. Eaves,et al.  Insights into the stem cells of chronic myeloid leukemia , 2010, Leukemia.

[17]  B. Mayer,et al.  Abi1/Hssh3bp1 pY213 links Abl kinase signaling to p85 regulatory subunit of PI‐3 kinase in regulation of macropinocytosis in LNCaP cells , 2010, FEBS letters.

[18]  D. Scadden,et al.  The leukemic stem cell niche: current concepts and therapeutic opportunities. , 2009, Blood.

[19]  G. Superti-Furga,et al.  Charting the molecular network of the drug target Bcr-Abl , 2009, Proceedings of the National Academy of Sciences.

[20]  A. Pendergast,et al.  Regulation of Cell-Cell Adhesion by Abi/Diaphanous Complexes , 2009, Molecular and Cellular Biology.

[21]  Yiguo Hu,et al.  Beta-catenin Is Essential for Survival of Leukemia Stem Cells Insensitive to Kinase Inhibition in Mice with BCR-ABL Induced Chronic Myeloid Leukemia. , 2008 .

[22]  Petra Beli,et al.  WAVE and Arp2/3 jointly inhibit filopodium formation by entering into a complex with mDia2 , 2008, Nature Cell Biology.

[23]  T. Holyoake,et al.  Enhanced BCR-ABL kinase inhibition does not result in increased inhibition of downstream signaling pathways or increased growth suppression in CML progenitors , 2008, Leukemia.

[24]  H. Qian,et al.  Distinct roles of integrins alpha6 and alpha4 in homing of fetal liver hematopoietic stem and progenitor cells. , 2007, Blood.

[25]  M. Gasparetto,et al.  Chronic myeloid leukemia stem cells possess multiple unique features of resistance to BCR-ABL targeted therapies , 2007, Leukemia.

[26]  G. Mills,et al.  Activation of integrin-linked kinase is a critical prosurvival pathway induced in leukemic cells by bone marrow-derived stromal cells. , 2007, Cancer research.

[27]  T. Rudel,et al.  A new interaction between Abi-1 and βPIX involved in PDGF-activated actin cytoskeleton reorganisation , 2006, Cell Research.

[28]  J. Melo,et al.  Bcr-Abl expression levels determine the rate of development of resistance to imatinib mesylate in chronic myeloid leukemia. , 2005, Cancer research.

[29]  K. Rottner,et al.  Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes , 2005, Nature Cell Biology.

[30]  R. Hwang,et al.  Integrin α4β1–VCAM-1–mediated adhesion between endothelial and mural cells is required for blood vessel maturation , 2005 .

[31]  C. Burge,et al.  Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets , 2005, Cell.

[32]  Andrea Disanza,et al.  Abi1 is essential for the formation and activation of a WAVE2 signalling complex , 2004, Nature Cell Biology.

[33]  A. Koleske,et al.  Abl-dependent tyrosine phosphorylation of Sos-1 mediates growth-factor-induced Rac activation , 2004, Nature Cell Biology.

[34]  H. Kuroda,et al.  Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia , 2003, Nature Medicine.

[35]  G. Scita,et al.  Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1 , 2003, The Journal of cell biology.

[36]  B. Druker,et al.  Activity of the Bcr-Abl kinase inhibitor PD180970 against clinically relevant Bcr-Abl isoforms that cause resistance to imatinib mesylate (Gleevec, STI571). , 2002, Cancer research.

[37]  S. McKenna,et al.  Elevated Bcr-Abl expression levels are sufficient for a haematopoietic cell line to acquire a drug-resistant phenotype , 2001, Leukemia.

[38]  G. Scita,et al.  An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin–polymerizing machine , 2001, The Journal of cell biology.

[39]  P. N. Rao,et al.  Clinical Resistance to STI-571 Cancer Therapy Caused by BCR-ABL Gene Mutation or Amplification , 2001, Science.

[40]  L. Gibson,et al.  Stromal cells regulate survival of B-lineage leukemic cells during chemotherapy. , 2000, Blood.

[41]  M. Varella‐Garcia,et al.  Induction of resistance to the Abelson inhibitor STI571 in human leukemic cells through gene amplification. , 2000, Blood.

[42]  C. Betsholtz,et al.  EPS8 and E3B1 transduce signals from Ras to Rac , 1999, Nature.

[43]  D. Cortez,et al.  Oncogenic Abl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway. , 1998, Genes & development.

[44]  R. Oostendorp,et al.  VLA-4-mediated interactions between normal human hematopoietic progenitors and stromal cells. , 1997, Leukemia & lymphoma.

[45]  S. Goff,et al.  Abl-interactor-1, a novel SH3 protein binding to the carboxy-terminal portion of the Abl protein, suppresses v-abl transforming activity. , 1995, Genes & development.

[46]  M. Labow,et al.  Defective development of the embryonic and extraembryonic circulatory systems in vascular cell adhesion molecule (VCAM-1) deficient mice. , 1995, Development.

[47]  R. Hynes,et al.  Cell adhesion events mediated by alpha 4 integrins are essential in placental and cardiac development. , 1995, Development.

[48]  A. Vara,et al.  A single mRNA encodes the α150 and α80/70 forms of the α subunit of VLA4 , 1992 .

[49]  T. Papayannopoulou,et al.  Hematopoietic stem cell mobilization: updated conceptual renditions , 2013, Leukemia.

[50]  D. Scadden,et al.  The hematopoietic stem cell niche. , 2012, Frontiers in bioscience.

[51]  R. Hwang,et al.  Integrin alpha4beta1-VCAM-1-mediated adhesion between endothelial and mural cells is required for blood vessel maturation. , 2005, The Journal of clinical investigation.

[52]  Paul Dent,et al.  Pharmacologic mitogen-activated protein/extracellular signal-regulated kinase kinase/mitogen-activated protein kinase inhibitors interact synergistically with STI571 to induce apoptosis in Bcr/Abl-expressing human leukemia cells. , 2002, Cancer research.

[53]  A. Vara,et al.  A single mRNA encodes the alpha 150 and alpha 80/70 forms of the alpha subunit of VLA4. , 1992, European journal of immunology.