The lin-14 locus of Caenorhabditis elegans controls the time of expression of specific postembryonic developmental events.

The lin-14 locus of Caenorhabditis elegans plays an important role in specifying the normal timing and sequence of developmental events in the lateral hypodermal cell lineages. The results of gene dosage, complementation, and temperature-shift experiments indicate that the fates expressed by cells at successive stages of these cell lineages are specified by the level of lin-14 activity and that lin-14 acts at multiple times during development to control stage-specific choices of cell fate. Our observations suggest that during normal development a reduction in the level of lin-14 gene function causes the sequential expression of stage-specific cell fates.

[1]  H. Horvitz,et al.  Heterochronic mutants of the nematode Caenorhabditis elegans. , 1984, Science.

[2]  T. Cline.  Autoregulatory functioning of a Drosophila gene product that establish es and maintains the sexually determined state. , 1984, Genetics.

[3]  T. Kaufman,et al.  Revertants of Dominant Mutations Associated with the Antennapedia Gene Complex of DROSOPHILA MELANOGASTER: Cytology and Genetics. , 1983, Genetics.

[4]  H. Horvitz,et al.  The lin-12 locus specifies cell fates in caenorhabditis elegans , 1983, Cell.

[5]  H. Horvitz,et al.  Gonadal cell lineages of the nematode Panagrellus redivivus and implications for evolution by the modification of cell lineage. , 1981, Developmental biology.

[6]  G. Struhl,et al.  A homoeotic mutation transforming leg to antenna in Drosophila , 1981, Nature.

[7]  D. Hirsh,et al.  The postembryonic cell lineages of the hermaphrodite and male gonads in Caenorhabditis elegans. , 1979, Developmental biology.

[8]  S. Brenner,et al.  Nondisjunction Mutants of the Nematode CAENORHABDITIS ELEGANS. , 1979, Genetics.

[9]  S. Brenner,et al.  Mutations causing transformation of sexual phenotype in the nematode Caenorhabditis elegans. , 1977, Genetics.

[10]  J. Sulston,et al.  Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. , 1977, Developmental biology.

[11]  P. Lawrence,et al.  Homoeotic genes, compartments and cell determination in Drosophila , 1977, Nature.

[12]  H. Horvitz,et al.  The genetic control of cell lineage during nematode development. , 1984, Annual review of genetics.

[13]  J. Sulston,et al.  Some Observations On Moulting in Caenorhabditis Elegans , 1978 .

[14]  W. J. Ouweneel.  Developmental genetics of homoeosis. , 1976, Advances in genetics.