Emerging Approaches to the Conceptualization and Treatment of Personality Disorder

Personality disorders are both prevalent and debilitating, but controversies abound concerning the definition, assessment and treatment of these conditions. This review examines major approaches to conceptualizing the personality disorders, as recently emerging in DSM-5, Section III, and the research domain criteria initiative of the National Institute of Mental Health. Three prominent models for understanding these disorders (neural functioning, interpersonal model, and the cognitive-affective processing system model) are considered with their relevant empirical foundations. The implications for future psychopathology and treatment research and practice are detailed. Personality disorders (PD) are prevalent in the general popula- tion (10.56% median prevalence across studies; see Lenzenweger, 2008). They are highly debilitating, exerting a powerful impact on work functioning as well as interpersonal and intimate relations. However, there are many impediments to the assessment and treatment of patients with a personality disorder, not the least of which are the controversies in defining personality disorder, the range of severity across the disorders, the difficulties in identifying the key dimensions of personality dysfunction, the striking heter- ogeneity amongst patients that carry the same personality disorder diagnosis, and the paucity of treatment research on the majority of the personality disorder types. In this overview, which is necessarily selective and nonexhaus- tive, we explore a number of empirical developments in person- ality pathology research, with a particularly focus on the potential impact of these developments on conceptualization, assessment and treatment. While there is substantial agreement about the limitations of the PD nosology articulated in the Diagnostic and Statistical Manual for Mental Disorders, now in its fifth edition (DSM-5; APA, 2013), there is less agreement about how to ad- vance our conceptualization. The alternative DSM-5 model for personality disorders, retained in Section 3 of the DSM-5, pro-

[1]  R. Depue,et al.  24 Toward a Developmental Psychopathology of Personality Disturbance: A Neurobehavioral Dimensional Model Incorporating Genetic, Environmental, and Epigenetic Factors† , 2016 .

[2]  W. Livesley,et al.  An Integrated Approach to Treatment of Patients With Personality Disorders , 2015 .

[3]  Nilam Ram,et al.  Enriching Psychological Assessment Using a Person-Specific Analysis of Interpersonal Processes in Daily Life , 2014, Assessment.

[4]  Nitin Gogtay,et al.  National Institute of Mental Health clinical trials: new opportunities, new expectations. , 2014, JAMA psychiatry.

[5]  George P. Knight,et al.  Empathy-Related Responding and Cognition: A “Chicken and the Egg” Dilemma , 2014 .

[6]  W. Rössler,et al.  Interpersonal functioning deficits in association with DSM-IV personality disorder dimensions , 2014, Social Psychiatry and Psychiatric Epidemiology.

[7]  M. Lenzenweger,et al.  Thinking clearly about the endophenotype–intermediate phenotype–biomarker distinctions in developmental psychopathology research , 2013, Development and Psychopathology.

[8]  Michael J. Roche,et al.  Pathological narcissism and interpersonal behavior in daily life. , 2013, Personality disorders.

[9]  R. Krueger Personality disorders are the vanguard of the post-DSM-5.0 era. , 2013, Personality disorders.

[10]  J. Gunderson Seeking clarity for future revisions of the personality disorders in DSM-5. , 2013, Personality disorders.

[11]  T. Widiger A postmortem and future look at the personality disorders in DSM-5. , 2013, Personality disorders.

[12]  J. Paris Anatomy of a debacle: commentary on "seeking clarity for future revisions of the personality disorders in DSM-5". , 2013, Personality disorders.

[13]  A. Arntz,et al.  Rejection sensitivity is a mediator between borderline personality disorder features and facial trust appraisal. , 2013, Journal of personality disorders.

[14]  A. Pincus,et al.  The interpersonal core of personality pathology. , 2013, Journal of personality disorders.

[15]  J. Clarkin The search for critical dimensions of personality pathology to inform diagnostic assessment and treatment planning: a commentary on Hopwood et al. , 2013, Journal of personality disorders.

[16]  L. Morey,et al.  Stability and change in personality disorders. , 2013, Annual review of clinical psychology.

[17]  Joel Paris,et al.  Quarrelsome behavior in borderline personality disorder: influence of behavioral and affective reactivity to perceptions of others. , 2013, Journal of abnormal psychology.

[18]  B. Renneberg,et al.  Perception of social participation in borderline personality disorder. , 2012, Clinical psychology & psychotherapy.

[19]  A. Pincus,et al.  A Contemporary Interpersonal Model of Personality Pathology and Personality Disorder , 2012 .

[20]  R. Krueger,et al.  An Interpersonal Analysis of Pathological Personality Traits in DSM-5 , 2012, Assessment.

[21]  G. Fitzmaurice,et al.  Attainment and stability of sustained symptomatic remission and recovery among patients with borderline personality disorder and axis II comparison subjects: a 16-year prospective follow-up study. , 2012, The American journal of psychiatry.

[22]  P. Owiti,et al.  Short-term diagnostic stability among re-admitted psychiatric in-patients in Eldoret, Kenya. , 2012, African journal of psychiatry.

[23]  T. McGlashan,et al.  Interpersonal pathoplasticity in the course of major depression. , 2012, Journal of consulting and clinical psychology.

[24]  Sarah E Hampson,et al.  Personality processes: mechanisms by which personality traits "get outside the skin". , 2012, Annual review of psychology.

[25]  Eshkol Rafaeli,et al.  The rejection-rage contingency in borderline personality disorder. , 2011, Journal of abnormal psychology.

[26]  Hauke R. Heekeren,et al.  Neuronal correlates of altered empathy and social cognition in borderline personality disorder , 2011, NeuroImage.

[27]  B. Renneberg,et al.  Rejection sensitivity and borderline personality disorder. , 2011, Clinical psychology & psychotherapy.

[28]  H. Heekeren,et al.  Lack of empathy in patients with narcissistic personality disorder , 2011, Psychiatry Research.

[29]  M. Stopsack,et al.  Facial emotional expression in reaction to social exclusion in borderline personality disorder , 2011, Psychological Medicine.

[30]  M. Kozak,et al.  Developing constructs for psychopathology research: research domain criteria. , 2010, Journal of abnormal psychology.

[31]  J. Decety The Neurodevelopment of Empathy in Humans , 2010, Developmental Neuroscience.

[32]  M. Lenzenweger Current Status of the Scientific Study of the Personality Disorders: an Overview of Epidemiological, Longitudinal, Experimental Psychopathology, and Neurobehavioral Perspectives , 2010, Journal of the American Psychoanalytic Association.

[33]  Sara C. Verosky,et al.  Neural Activity to a Partner's Facial Expression Predicts Self-Regulation After Conflict , 2010, Biological Psychiatry.

[34]  G. Downey,et al.  Rejection sensitivity and the rejection-hostility link in romantic relationships. , 2010, Journal of personality.

[35]  G. Stricker American Psychological Association Code of Ethics , 2010 .

[36]  R. Blair,et al.  Neuroimaging of Psychopathy and Antisocial Behavior: A Targeted Review , 2010, Current psychiatry reports.

[37]  Erik Woody,et al.  Are we on the same wavelength? Interpersonal complementarity as shared cyclical patterns during interactions. , 2009, Journal of personality and social psychology.

[38]  T. Trull,et al.  Using experience sampling methods/ecological momentary assessment (ESM/EMA) in clinical assessment and clinical research: introduction to the special section. , 2009, Psychological assessment.

[39]  Jin Fan,et al.  Neural Correlates of the Use of Psychological Distancing to Regulate Responses to Negative Social Cues: A Study of Patients with Borderline Personality Disorder , 2009, Biological Psychiatry.

[40]  Hu Cheng,et al.  Neural correlates of emotion processing in borderline personality disorder , 2009, Psychiatry Research: Neuroimaging.

[41]  R. Krueger,et al.  The Cognitive-Affective Processing System (CAPS) approach to personality and the concept of personality disorder: Integrating clinical and social-cognitive research , 2009 .

[42]  M. Lenzenweger Epidemiology of personality disorders. , 2008, The Psychiatric clinics of North America.

[43]  Jean Decety,et al.  From emotion resonance to empathic understanding: A social developmental neuroscience account , 2008, Development and Psychopathology.

[44]  Kenneth N. Levy,et al.  Refining the borderline personality disorder phenotype through finite mixture modeling: implications for classification. , 2008, Journal of personality disorders.

[45]  J. Gross,et al.  Cognitive Emotion Regulation , 2008, Current directions in psychological science.

[46]  G. Downey,et al.  Rejection Sensitivity and Executive Control: Joint predictors of Borderline Personality features. , 2008, Journal of research in personality.

[47]  K. Lyons-Ruth,et al.  BPD's interpersonal hypersensitivity phenotype: a gene-environment-developmental model. , 2008, Journal of personality disorders.

[48]  Lee Anna Clark,et al.  Assessment and diagnosis of personality disorder: perennial issues and an emerging reconceptualization. , 2007, Annual review of psychology.

[49]  B. Mesquita,et al.  Social cognitive neuroscience: a review of core processes. , 2007, Annual review of psychology.

[50]  David Silbersweig,et al.  Failure of frontolimbic inhibitory function in the context of negative emotion in borderline personality disorder. , 2007, The American journal of psychiatry.

[51]  A. Skodol,et al.  Borderline personality as a self-other representational disturbance. , 2007, Journal of personality disorders.

[52]  R. Kessler,et al.  DSM-IV Personality Disorders in the National Comorbidity Survey Replication , 2007, Biological Psychiatry.

[53]  D. Zuroff,et al.  Stability and variability of affective experience and interpersonal behavior in borderline personality disorder. , 2007, Journal of abnormal psychology.

[54]  A. Kazdin Mediators and mechanisms of change in psychotherapy research. , 2007, Annual review of clinical psychology.

[55]  M. Lenzenweger The longitudinal study of personality disorders: history, design considerations, and initial findings. , 2006, Journal of personality disorders.

[56]  T. Trull Dimensional models of personality disorder: coverage and cutoffs. , 2005, Journal of personality disorders.

[57]  Avshalom Caspi,et al.  Personality development: stability and change. , 2005, Annual review of psychology.

[58]  C. Liston,et al.  Imaging the developing brain: what have we learned about cognitive development? , 2005, Trends in Cognitive Sciences.

[59]  J. Willett,et al.  Individual growth curve analysis illuminates stability and change in personality disorder features: the longitudinal study of personality disorders. , 2004, Archives of general psychiatry.

[60]  M. Posner,et al.  Individual Differences in Executive Attention Predict Self‐Regulation and Adolescent Psychosocial Behaviors , 2004, Annals of the New York Academy of Sciences.

[61]  Walter Mischel,et al.  Toward an integrative science of the person. , 2004, Annual review of psychology.

[62]  Matthew D. Lieberman,et al.  Does Rejection Hurt? An fMRI Study of Social Exclusion , 2003, Science.

[63]  O. John,et al.  Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being. , 2003, Journal of personality and social psychology.

[64]  A. Pincus,et al.  Interpersonal Theory of Personality , 2003 .

[65]  I. Gottesman,et al.  The endophenotype concept in psychiatry: etymology and strategic intentions. , 2003, The American journal of psychiatry.

[66]  J. Hennen,et al.  The longitudinal course of borderline psychopathology: 6-year prospective follow-up of the phenomenology of borderline personality disorder. , 2003, The American journal of psychiatry.

[67]  T. McGlashan,et al.  Short-term diagnostic stability of schizotypal, borderline, avoidant, and obsessive-compulsive personality disorders. , 2002, The American journal of psychiatry.

[68]  J. Gabrieli,et al.  Rethinking Feelings: An fMRI Study of the Cognitive Regulation of Emotion , 2002, Journal of Cognitive Neuroscience.

[69]  M. Posner,et al.  Developing mechanisms of self-regulation , 2000, Development and Psychopathology.

[70]  T. Trull Dimensional models of personality disorder , 2000 .

[71]  J. Safran,et al.  Negotiating the Therapeutic Alliance: A Relational Treatment Guide , 2000 .

[72]  J. Clarkin Research findings on the personality disorders , 1999 .

[73]  J. Kagan,et al.  Adolescent social anxiety as an outcome of inhibited temperament in childhood. , 1999, Journal of the American Academy of Child and Adolescent Psychiatry.

[74]  R. Davidson Affective Style and Affective Disorders: Perspectives from Affective Neuroscience , 1998 .

[75]  G. Downey,et al.  Implications of rejection sensitivity for intimate relationships. , 1996, Journal of personality and social psychology.

[76]  O. Kernberg Severe Personality Disorders: Psychotherapeutic Strategies , 1984 .

[77]  P. Harris,et al.  Children's knowledge of emotion. , 1981, Journal of child psychology and psychiatry, and allied disciplines.

[78]  T. Widiger,et al.  Dimensional Models of Personality Disorders: Refining the Research Agenda for DSM^V , 2017 .

[79]  N. Eisenberg,et al.  The development of prosocial moral reasoning and a prosocial orientation in young adulthood: concurrent and longitudinal correlates. , 2014, Developmental psychology.

[80]  E. Woody,et al.  Momentary assessment of interpersonal process in psychotherapy. , 2014, Journal of counseling psychology.

[81]  James J. Gross,et al.  Handbook of emotion regulation, 2nd ed. , 2014 .

[82]  M. Carter Diagnostic and Statistical Manual of Mental Disorders, 5th ed. , 2014 .

[83]  A. Pincus,et al.  SPECIAL SERIES: Integrating Personality, Psychopathology, and Psychotherapy Using Interpersonal Assessment Interpersonal Subtypes in Social Phobia: Diagnostic and Treatment Implications , 2010 .

[84]  L. Siever,et al.  The interpersonal dimension of borderline personality disorder: toward a neuropeptide model. , 2010, The American journal of psychiatry.

[85]  P. Fonagy,et al.  Mentalization-based treatment and borderline personality disorder , 2010 .

[86]  P. Costa,et al.  NEO inventories for the NEO Personality Inventory-3 (NEO-PI-3), NEO Five-Factor Inventory-3 (NEO-FFI-3), NEO Personality Inventory-Revised (NEO PI-R) : professional manual , 2010 .

[87]  W. Mischel,et al.  Toward a unified theory of personality: Integrating dispositions and processing dynamics within the cognitive-affective processing system. , 2008 .

[88]  I. Bretherton,et al.  Internal working models in attachment relationships: Elaborating a central construct in attachment theory. , 2008 .

[89]  R. von Känel,et al.  BioPsychoSocial Medicine BioMed Central Review , 2007 .

[90]  J. Paris Why Psychiatrists are Reluctant to Diagnose: Borderline Personality Disorder. , 2007, Psychiatry (Edgmont (Pa. : Township)).

[91]  Ross A. Thompson,et al.  Emotion regulation: Conceptual foundations , 2007 .

[92]  T. Widiger,et al.  Comprar Dimensional Models of Personality Disorders. Refining the Research Agenda for DSM-V | Thomas A. Widiger | 9780890422960 | American Psychiatric Publishing , 2007 .

[93]  R. Depue,et al.  A Multidimensional Neurobehavioral Model of Personality Disturbance. , 2006 .

[94]  Aaron L. Pincus,et al.  A Contemporary Integrative Interpersonal Theory of Personality Disorders. , 2005 .

[95]  Daniel Cervone,et al.  Personality architecture: within-person structures and processes. , 2005, Annual review of psychology.

[96]  P. Pilkonis,et al.  An Attachment Model of Personality Disorders. , 2005 .

[97]  M. Lenzenweger,et al.  Major theories of personality disorder, 2nd ed. , 2005 .

[98]  Leonard M. Horowitz,et al.  Interpersonal Foundations of Psychopathology , 2004 .

[99]  W. J. Livesley Conceptual and taxonomic issues. , 2001 .

[100]  I. Bretherton,et al.  Internal working models in attachment relationships: A construct revisited. , 1999 .

[101]  A. Hassiotis Assessment and diagnosis of personality disorders , 1997 .

[102]  A. Beck,et al.  A cognitive theory of personality disorders. , 1996 .

[103]  O. Kernberg,et al.  A Psychoanalytic Theory of Personality Disorders. , 1996 .

[104]  S. Blatt Representational structures in psychopathology. , 1995 .

[105]  R. Michels,et al.  Diagnostic and Statistical Manual of Mental Disorders, 3rd ed , 1981 .

[106]  Lori N. Scott,et al.  Clarifying Interpersonal Heterogeneity in Borderline Personality Disorder Using Latent Mixture Modeling Nih Public Access Comparing the Classes on Bpd Symptoms and Auxiliary Variables , 2022 .