Ear lobe crease and coronary artery disease. 1,000 patients and review of the literature.

One thousand unselected patients admitted to large urban medical centers were examined for the presence of a diagonal ear lobe crease and evaluated for the presence of coronary artery disease. A high degree of correlation between the two was seen, using both clinical and angiographic criteria for the diagnosis of coronary artery disease. The association between the ear lobe crease and coronary artery disease was independent of patient age. Prospective analysis of single risk factors in 112 consecutive patients subjected to coronary cineangiography revealed that demonstrable coronary artery disease was correlated only with the ear lobe crease and with previous acute myocardial infarction (although less strongly with the latter). These conclusions are consistent with those of the world's literature, which also finds a strong correlation between coronary artery disease and the ear lobe crease, with the exception of Oriental patients, native American Indian patients, and children with Beckwith's syndrome.

[1]  K. Yano,et al.  Ear-lobe crease and coronary-artery heart disease. , 1977, Annals of internal medicine.

[2]  G. W. Snedecor.  STATISTICAL METHODS , 1967 .

[3]  J. Burton.  EAR-LOBE CREASE , 1979, The Lancet.

[4]  Christiansen Js,et al.  Letter: diagonal ear-lobe crease and diabetic retinal angiopathy. , 1976 .

[5]  A. Pasternac,et al.  Predictive value of the ear-crease sign in coronary artery disease. , 1982, Canadian Medical Association journal.

[6]  B. Kristensen.  EAR-LOBE CREASE AND VASCULAR COMPLICATIONS IN ESSENTIAL HYPERTENSION , 1980, The Lancet.

[7]  T. Smith.  Health care in china. , 1980, The Western journal of medicine.

[8]  S. Kaukola.  The diagonal ear-lobe crease, a physical sign associated with coronary heart disease. , 1978, Acta medica Scandinavica. Supplementum.

[9]  D. Phillips,et al.  Ear‐Lobe Creases and Heart Disease , 1977, Journal of the American Geriatrics Society.

[10]  Kopriva Cj.  Letter: Anesthesia and propranolol. , 1974 .

[11]  I. Chapman,et al.  Letter: Diagonal ear-lobe crease and coronary artery sclerosis. , 1976, Annals of internal medicine.

[12]  Y. Shoenfeld,et al.  Diagonal Ear Lobe Crease and Coronary Risk Factors , 1980, Journal of the American Geriatrics Society.

[13]  S. Frank.  Ear-crease sign of coronary disease. , 1977, New England Journal of Medicine.

[14]  P. Merlob,et al.  Diagonal earlobe crease in newborn infants and in children. , 1981, Clinical pediatrics.

[15]  A. M. Gilchrist,et al.  Diagonal ear-lobe crease: an independent risk factor in coronary heart disease? , 1980, The Ulster medical journal.

[16]  N. L. Petrakis.  Diagonal earlobe creases, type A behavior and the death of Emperor Hadrian. , 1980, The Western journal of medicine.

[17]  V. Manninen,et al.  EAR-LOBE CREASE AND CORONARY ATHEROSCLEROSIS , 1979, The Lancet.

[18]  Benjamín Moncada,et al.  EAR-LOBE CREASE , 1979, The Lancet.

[19]  K. Yano,et al.  The earlobe crease--sign of obesity in middle-aged Japanese men. , 1977, Hawaii medical journal.

[20]  M. Sievers,et al.  Ear-lobe crease in American Indians. , 1980, Annals of internal medicine.

[21]  D. Teres,et al.  Letter: Diagonal ear-lobe crease as a coronary risk factor. , 1974 .

[22]  D. Sprague.  Diagonal ear-lobe crease as an indicator of operative risk. , 1976, Anesthesiology.

[23]  E. Lichstein,et al.  Diagonal ear-lobe crease: prevalence and implications as a coronary risk factor. , 1974, The New England journal of medicine.

[24]  J. Christiansen,et al.  Letter: Diagonal ear-lobe crease in coronary heart disease. , 1975, The New England journal of medicine.

[25]  Wyre Hw.  The diagonal earlobe crease: a cutaneous manifestation of coronary artery disease. , 1979 .

[26]  S. Haines.  Nonspecificity of ear-crease sign in coronary-artery disease. , 1977, The New England journal of medicine.

[27]  Frank St,et al.  Aural sign of coronary-artery disease. , 1973 .