Protein interactomes of protein phosphatase 2A B55 regulatory subunits reveal B55-mediated regulation of replication protein A under replication stress

[1]  M. Goldberg,et al.  Cell cycle-dependent regulation of Greatwall kinase by protein phosphatase 1 and regulatory subunit 3B , 2017, The Journal of Biological Chemistry.

[2]  Lynette M. Smith,et al.  S4S8-RPA phosphorylation as an indicator of cancer progression in oral squamous cell carcinomas , 2016, Oncotarget.

[3]  B. Novák,et al.  A PP2A-B55 recognition signal controls substrate dephosphorylation kinetics during mitotic exit , 2016, The Journal of cell biology.

[4]  N. Wlodarchak,et al.  PP2A as a master regulator of the cell cycle , 2016, Critical reviews in biochemistry and molecular biology.

[5]  Myreille Larouche,et al.  Spatial regulation of greatwall by Cdk1 and PP2A-Tws in the cell cycle , 2016, Cell cycle.

[6]  D. Görlich,et al.  A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning , 2015, eLife.

[7]  Marco Y. Hein,et al.  A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances , 2015, Cell.

[8]  F. Boisvert,et al.  Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage* , 2015, Molecular & Cellular Proteomics.

[9]  A. Peng,et al.  Regulation of polo-like kinase 1 by DNA damage and PP2A/B55α , 2015, Cell cycle.

[10]  L. Zou,et al.  RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response , 2014, Cell Research.

[11]  G. Oakley,et al.  RPA inhibition increases replication stress and suppresses tumor growth. , 2014, Cancer research.

[12]  S. Opiyo,et al.  DNA-PK phosphorylation of RPA32 Ser4/Ser8 regulates replication stress checkpoint activation, fork restart, homologous recombination and mitotic catastrophe. , 2014, DNA repair.

[13]  C. Schildkraut,et al.  Phosphorylated RPA recruits PALB2 to stalled DNA replication forks to facilitate fork recovery , 2014, The Journal of cell biology.

[14]  A. Peng,et al.  Phosphatase 1 Nuclear Targeting Subunit Is an Essential Regulator of M-phase Entry, Maintenance, and Exit* , 2014, The Journal of Biological Chemistry.

[15]  Sandra Zazo,et al.  PP2A Inhibition Is a Common Event in Colorectal Cancer and Its Restoration Using FTY720 Shows Promising Therapeutic Potential , 2014, Molecular Cancer Therapeutics.

[16]  P. K. Vinod,et al.  PP2A/B55 and Fcp1 Regulate Greatwall and Ensa Dephosphorylation during Mitotic Exit , 2014, PLoS genetics.

[17]  S. Batra,et al.  Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer. , 2013, Cancer letters.

[18]  A. Castro,et al.  Budding Yeast Greatwall and Endosulfines Control Activity and Spatial Regulation of PP2ACdc55 for Timely Mitotic Progression , 2013, PLoS genetics.

[19]  T. Hunt.  On the regulation of protein phosphatase 2A and its role in controlling entry into and exit from mitosis. , 2013, Advances in biological regulation.

[20]  M. Boccadoro,et al.  Genome‐wide analysis of primary plasma cell leukemia identifies recurrent imbalances associated with changes in transcriptional profiles , 2013, American journal of hematology.

[21]  Sebastian Munck,et al.  Loss of PPP2R2A inhibits homologous recombination DNA repair and predicts tumor sensitivity to PARP inhibition. , 2012, Cancer research.

[22]  S. Opiyo,et al.  Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress , 2012, Nucleic acids research.

[23]  F. Markowetz,et al.  The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups , 2012, Nature.

[24]  S. Halpain,et al.  The Protein Phosphatase PP2A/Bα Binds to the Microtubule-associated Proteins Tau and MAP2 at a Motif Also Recognized by the Kinase Fyn , 2012, The Journal of Biological Chemistry.

[25]  Daniel W. Gerlich,et al.  Phosphatases: providing safe passage through mitotic exit , 2011, Nature Reviews Molecular Cell Biology.

[26]  Yu Cheng,et al.  Evaluation of PPP2R2A as a prostate cancer susceptibility gene: a comprehensive germline and somatic study. , 2011, Cancer genetics.

[27]  A. Lewellyn,et al.  Regulation of Greatwall kinase during Xenopus oocyte maturation , 2011, Molecular biology of the cell.

[28]  Qiang Yu,et al.  B55β-associated PP2A complex controls PDK1-directed myc signaling and modulates rapamycin sensitivity in colorectal cancer. , 2010, Cancer cell.

[29]  Otto Hudecz,et al.  Live-cell imaging RNAi screen identifies PP2A–B55α and importin-β1 as key mitotic exit regulators in human cells , 2010, Nature Cell Biology.

[30]  E. Schiebel,et al.  Cdc14: a highly conserved family of phosphatases with non-conserved functions? , 2010, Journal of Cell Science.

[31]  G. Oakley,et al.  Replication protein A: directing traffic at the intersection of replication and repair. , 2010, Frontiers in bioscience.

[32]  J. Turchi,et al.  Targeted inhibition of Replication Protein A reveals cytotoxic activity, synergy with chemotherapeutic DNA-damaging agents, and insight into cellular function. , 2010, Cancer research.

[33]  Yunfeng Pan,et al.  A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination , 2010, Nature Structural &Molecular Biology.

[34]  T. Sørlie,et al.  Frequent aberrant DNA methylation of ABCB1, FOXC1, PPP2R2B and PTEN in ductal carcinoma in situ and early invasive breast cancer , 2010, Breast Cancer Research.

[35]  P. De Wulf,et al.  Protein phosphatases take the mitotic stage. , 2009, Current opinion in cell biology.

[36]  J. Borowiec,et al.  Human RPA phosphorylation by ATR stimulates DNA synthesis and prevents ssDNA accumulation during DNA-replication stress , 2009, Journal of Cell Science.

[37]  Yigong Shi.  Serine/Threonine Phosphatases: Mechanism through Structure , 2009, Cell.

[38]  D. Gerlich,et al.  Mitotic phosphatases: from entry guards to exit guides. , 2009, Trends in cell biology.

[39]  Tim Hunt,et al.  Regulated activity of PP2A–B55δ is crucial for controlling entry into and exit from mitosis in Xenopus egg extracts , 2009, The EMBO journal.

[40]  Xiao-Fan Wang,et al.  Protein Phosphatase 2A-Dependent Dephosphorylation of Replication Protein A Is Required for the Repair of DNA Breaks Induced by Replication Stress , 2009, Molecular and Cellular Biology.

[41]  G. Oakley,et al.  Physical interaction between replication protein A (RPA) and MRN: involvement of RPA2 phosphorylation and the N-terminus of RPA1. , 2009, Biochemistry.

[42]  A. Lewellyn,et al.  Repo-Man Controls a Protein Phosphatase 1-Dependent Threshold for DNA Damage Checkpoint Activation , 2009, Current Biology.

[43]  S. Shenolikar,et al.  From promiscuity to precision: protein phosphatases get a makeover. , 2009, Molecular cell.

[44]  R. Aebersold,et al.  An integrated workflow for charting the human interaction proteome: insights into the PP2A system , 2009, Molecular systems biology.

[45]  Jianfeng Xu,et al.  Homozygous deletions and recurrent amplifications implicate new genes involved in prostate cancer. , 2008, Neoplasia.

[46]  S. Höning,et al.  Characterization of a Protein Phosphatase 2A Holoenzyme That Dephosphorylates the Clathrin Adaptors AP-1 and AP-2* , 2008, Journal of Biological Chemistry.

[47]  P. R. Yew,et al.  The Xenopus Cell Cycle: An Overview , 2008, Molecular biotechnology.

[48]  Xin Cai,et al.  Serine 15 Phosphorylation of p53 Directs Its Interaction with B56γ and the Tumor Suppressor Activity of B56γ-Specific Protein Phosphatase 2A , 2007, Molecular and Cellular Biology.

[49]  K. Cimprich,et al.  Analyzing the ATR-mediated checkpoint using Xenopus egg extracts. , 2007, Methods.

[50]  J. Bishop,et al.  Prolactin activates mammalian target-of-rapamycin through phosphatidylinositol 3-kinase and stimulates phosphorylation of p70S6K and 4E-binding protein-1 in lymphoma cells. , 2006, The Journal of endocrinology.

[51]  Y. Zou,et al.  Functions of human replication protein A (RPA): From DNA replication to DNA damage and stress responses , 2006, Journal of cellular physiology.

[52]  Ioannis Panagopoulos,et al.  Fusion of the tumor-suppressor gene CHEK2 and the gene for the regulatory subunit B of protein phosphatase 2 PPP2R2A in childhood teratoma. , 2006, Neoplasia.

[53]  S. Pelech,et al.  Positive Regulation of Raf1-MEK1/2-ERK1/2 Signaling by Protein Serine/Threonine Phosphatase 2A Holoenzymes* , 2005, Journal of Biological Chemistry.

[54]  Angelika Amon,et al.  Closing mitosis: the functions of the Cdc14 phosphatase and its regulation. , 2004, Annual review of genetics.

[55]  Sara K. Binz,et al.  Replication protein A phosphorylation and the cellular response to DNA damage. , 2004, DNA repair.

[56]  S. Shenolikar,et al.  PP1 control of M phase entry exerted through 14‐3‐3‐regulated Cdc25 dephosphorylation , 2003, The EMBO journal.

[57]  D. Burke,et al.  Cdc55p, the B-type regulatory subunit of protein phosphatase 2A, has multiple functions in mitosis and is required for the kinetochore/spindle checkpoint in Saccharomyces cerevisiae , 1997, Molecular and cellular biology.

[58]  T. Hunter,et al.  Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling , 1995, Cell.

[59]  Sabine Petry,et al.  Visualizing and Analyzing Branching Microtubule Nucleation Using Meiotic Xenopus Egg Extracts and TIRF Microscopy. , 2016, Methods in molecular biology.

[60]  Jiaxiang Wang,et al.  Upregulation of miR-136 in human non-small cell lung cancer cells promotes Erk1/2 activation by targeting PPP2R2A , 2013, Tumor Biology.

[61]  K. Deshmukh,et al.  Identification of substrates for cyclin dependent kinases. , 2010, Advances in enzyme regulation.

[62]  Xin Cai,et al.  Serine 15 phosphorylation of p53 directs its interaction with B56gamma and the tumor suppressor activity of B56gamma-specific protein phosphatase 2A. , 2008, Molecular and cellular biology.

[63]  P. Mahadevan,et al.  An overview , 2007, Journal of Biosciences.

[64]  S. Kornbluth,et al.  Study of apoptosis in vitro using the Xenopus egg extract reconstitution system. , 2006, Methods in molecular biology.

[65]  J. Ruderman,et al.  Using Xenopus oocyte extracts to study signal transduction. , 2006, Methods in molecular biology.