Differential Expression of Klotho in the Brain and Spinal Cord is Associated with Total Antioxidant Capacity in Mice with Experimental Autoimmune Encephalomyelitis

[1]  C. Schmitz,et al.  Combination of cuprizone and experimental autoimmune encephalomyelitis to study inflammatory brain lesion formation and progression , 2017, Glia.

[2]  A. Allameh,et al.  Klotho gene expression decreases in peripheral blood mononuclear cells (PBMCs) of patients with relapsing-remitting multiple sclerosis , 2017, Journal of the Neurological Sciences.

[3]  C. Scavone,et al.  The relevance of α-KLOTHO to the central nervous system: Some key questions , 2017, Ageing Research Reviews.

[4]  G. Mann,et al.  The anti‐ageing hormone klotho induces Nrf2‐mediated antioxidant defences in human aortic smooth muscle cells , 2016, Journal of cellular and molecular medicine.

[5]  M. Harirchian,et al.  Multiple sclerosis influences on the augmentation of serum Klotho concentration , 2016, Journal of the Neurological Sciences.

[6]  N. Grigoriadis,et al.  A basic overview of multiple sclerosis immunopathology , 2015, European journal of neurology.

[7]  C. Abraham,et al.  The Anti-Aging Protein Klotho Enhances Remyelination Following Cuprizone-Induced Demyelination , 2015, Journal of Molecular Neuroscience.

[8]  M. Harirchian,et al.  Decreased concentration of Klotho in the cerebrospinal fluid of patients with relapsing–remitting multiple sclerosis , 2015, Journal of Neuroimmunology.

[9]  D. Harris,et al.  The Neuroprotective Effect of Klotho is Mediated via Regulation of Members of the Redox System* , 2014, The Journal of Biological Chemistry.

[10]  J. Goverman,et al.  Cytokine-Regulated Neutrophil Recruitment Is Required for Brain but Not Spinal Cord Inflammation during Experimental Autoimmune Encephalomyelitis , 2014, The Journal of Immunology.

[11]  M. Juliano,et al.  Differential brain and spinal cord cytokine and BDNF levels in experimental autoimmune encephalomyelitis are modulated by prior and regular exercise , 2013, Journal of Neuroimmunology.

[12]  M. Hessner,et al.  Mast cell activation and neutrophil recruitment promotes early and robust inflammation in the meninges in EAE. , 2013, Journal of autoimmunity.

[13]  H. Tedeschi,et al.  Hippocampal gene expression dysregulation of Klotho, nuclear factor kappa B and tumor necrosis factor in temporal lobe epilepsy patients , 2013, Journal of Neuroinflammation.

[14]  J. Luebke,et al.  The Antiaging Protein Klotho Enhances Oligodendrocyte Maturation and Myelination of the CNS , 2013, The Journal of Neuroscience.

[15]  Jiang-Fan Chen,et al.  Genetic inactivation of the adenosine A2A receptor exacerbates brain damage in mice with experimental autoimmune encephalomyelitis , 2012, Journal of neurochemistry.

[16]  D. Geschwind,et al.  Lipocalin 2 is present in the EAE brain and is modulated by natalizumab , 2012, Front. Cell. Neurosci..

[17]  M. Sánchez-Niño,et al.  The inflammatory cytokines TWEAK and TNFα reduce renal klotho expression through NFκB. , 2011, Journal of the American Society of Nephrology : JASN.

[18]  P. Balasubramanian,et al.  Linking Klotho, Nrf2, MAP kinases and aging , 2010, Aging.

[19]  D. Besselsen,et al.  Tumor necrosis factor and interferon-gamma down-regulate Klotho in mice with colitis. , 2010, Gastroenterology.

[20]  T. Katsuya,et al.  Klotho suppresses TNF-α-induced expression of adhesion molecules in the endothelium and attenuates NF-κB activation , 2009, Endocrine.

[21]  P. Lehmann,et al.  Fundamental differences in the dynamics of CNS lesion development and composition in MP4- and MOG peptide 35-55-induced experimental autoimmune encephalomyelitis. , 2008, Clinical immunology.

[22]  M. Kuro-o Klotho as a regulator of oxidative stress and senescence , 2008, Biological chemistry.

[23]  Stefanie Kuerten,et al.  MP4- and MOG:35–55-induced EAE in C57BL/6 mice differentially targets brain, spinal cord and cerebellum , 2007, Journal of Neuroimmunology.

[24]  A. Allameh,et al.  Relationship between the clinical scoring and demyelination in central nervous system with total antioxidant capacity of plasma during experimental autoimmune encephalomyelitis development in mice , 2007, Neuroscience Letters.

[25]  Ż. Smoleńska,et al.  Klotho—a Common Link in Physiological and Rheumatoid Arthritis-Related Aging of Human CD4+ Lymphocytes1 , 2007, The Journal of Immunology.

[26]  H. Yamada,et al.  Immunohistochemical localization of Klotho protein in brain, kidney, and reproductive organs of mice. , 2004, Cell structure and function.

[27]  K. Nozaki,et al.  Secreted Klotho protein in sera and CSF: implication for post‐translational cleavage in release of Klotho protein from cell membrane , 2004, FEBS letters.

[28]  Daniel Offen,et al.  The role of oxidative stress in the pathogenesis of multiple sclerosis: The need for effective antioxidant therapy , 2004, Journal of Neurology.

[29]  T. Nabeshima,et al.  Cognition impairment in the genetic model of aging klotho gene mutant mice: a role of oxidative stress , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[30]  Tadashi Kaname,et al.  Mutation of the mouse klotho gene leads to a syndrome resembling ageing , 1997, Nature.

[31]  J J Strain,et al.  The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. , 1996, Analytical biochemistry.

[32]  L Steinman,et al.  Multiple Sclerosis: A Coordinated Immunological Attack against Myelin in the Central Nervous System , 1996, Cell.

[33]  M. M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. , 1976, Analytical biochemistry.