Expression Flagellin-Induced Proinflammatory Gene Activation Negatively Regulates TLR 5-Mediated Phosphoinositide 3-Kinase

[1]  Judy H Cho,et al.  Dominant-negative TLR5 polymorphism reduces adaptive immune response to flagellin and negatively associates with Crohn's disease. , 2006, American journal of physiology. Gastrointestinal and liver physiology.

[2]  A. Gewirtz,et al.  Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. , 2006, American journal of physiology. Gastrointestinal and liver physiology.

[3]  Xi Na,et al.  Clostridium difficile toxin A-induced colonocyte apoptosis involves p53-dependent p21(WAF1/CIP1) induction via p38 mitogen-activated protein kinase. , 2005, Gastroenterology.

[4]  S. Sakamoto,et al.  Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling , 2004, Nature Structural &Molecular Biology.

[5]  D. Merlin,et al.  STAT Signaling Underlies Difference between Flagellin-induced and Tumor Necrosis Factor-α-induced Epithelial Gene Expression* , 2004, Journal of Biological Chemistry.

[6]  J. Johnston,et al.  SOCS: role in inflammation, allergy and homeostasis. , 2004, Trends in immunology.

[7]  Shizuo Akira,et al.  Toll-like receptor signalling , 2004, Nature Reviews Immunology.

[8]  M. Abreu,et al.  Innate immunity and toll-like receptors: clinical implications of basic science research. , 2004, The Journal of pediatrics.

[9]  S. Koyasu,et al.  PI3K and negative regulation of TLR signaling. , 2003, Trends in immunology.

[10]  D. Merlin,et al.  TLR5-mediated activation of p38 MAPK regulates epithelial IL-8 expression via posttranscriptional mechanism. , 2003, American journal of physiology. Gastrointestinal and liver physiology.

[11]  A. Gewirtz Intestinal epithelial toll-like receptors: to protect. And serve? , 2003, Current pharmaceutical design.

[12]  R. Flavell,et al.  The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors , 2002, Nature.

[13]  A. Gewirtz,et al.  Bacterial Flagellin Is an Effective Adjuvant for CD4+ T Cells In Vivo1 , 2002, The Journal of Immunology.

[14]  G. Calamita,et al.  Functional involvement of VAMP/synaptobrevin-2 in cAMP-stimulated aquaporin 2 translocation in renal collecting duct cells , 2002, Journal of Cell Science.

[15]  T. Asano,et al.  PI3K-mediated negative feedback regulation of IL-12 production in DCs , 2002, Nature Immunology.

[16]  Charles A. Janeway,et al.  IRAK-M Is a Negative Regulator of Toll-like Receptor Signaling , 2002, Cell.

[17]  M. J. Cody,et al.  TLR4, but not TLR2, mediates IFN-β–induced STAT1α/β-dependent gene expression in macrophages , 2002, Nature Immunology.

[18]  Y. Sung,et al.  Cutting Edge: CpG DNA Inhibits Dendritic Cell Apoptosis by Up-Regulating Cellular Inhibitor of Apoptosis Proteins Through the Phosphatidylinositide-3′-OH Kinase Pathway1 , 2002, The Journal of Immunology.

[19]  J. Madara,et al.  21 Modeling microbial-epithelial interactions in the intestine , 2002 .

[20]  P. Godowski,et al.  Cutting Edge: Bacterial Flagellin Activates Basolaterally Expressed TLR5 to Induce Epithelial Proinflammatory Gene Expression1 , 2001, The Journal of Immunology.

[21]  S. Akira,et al.  The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5 , 2001, Nature.

[22]  C. Hagedorn,et al.  Salmonella typhimurium translocates flagellin across intestinal epithelia, inducing a proinflammatory response. , 2001, The Journal of clinical investigation.

[23]  P. Godowski,et al.  Toll-like receptor 2–mediated NF-κB activation requires a Rac1-dependent pathway , 2000, Nature Immunology.

[24]  G. Kollias,et al.  Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. , 1999, Immunity.

[25]  Y. Yazaki,et al.  Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase. , 1999, Science.

[26]  J. Woodgett,et al.  MLK‐3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6. , 1996, The EMBO journal.