Neurotrophin signaling is a central mechanism of salivary dysfunction after irradiation that disrupts myoepithelial cells

[1]  Atique U. Ahmed,et al.  Cell Lineage and Pseudotime Inference for Single-cell Transcriptomics Analysis of Chemoresistance in GBM (P11-13.002) , 2023, Wednesday, April 26.

[2]  S. Bellusci,et al.  A mesenchymal to epithelial switch in Fgf10 expression specifies an evolutionary-conserved population of ionocytes in salivary glands , 2022, Cell reports.

[3]  S. Quake.  The Tabula Sapiens: a multiple organ single cell transcriptomic atlas of humans , 2021, bioRxiv.

[4]  Ryan D. Chow,et al.  Epithelial cell plasticity: breaking boundaries and changing landscapes , 2021, EMBO reports.

[5]  R. Coppes,et al.  The evolving definition of salivary gland stem cells , 2021, npj Regenerative Medicine.

[6]  G. Proctor,et al.  Comparing development and regeneration in the submandibular gland highlights distinct mechanisms , 2021, Journal of anatomy.

[7]  K. Limesand,et al.  Radiation-Induced Salivary Gland Dysfunction: Mechanisms, Therapeutics and Future Directions , 2020, Journal of clinical medicine.

[8]  Michael C. Kelly,et al.  Generation of a Single-Cell RNAseq Atlas of Murine Salivary Gland Development , 2020, iScience.

[9]  Longjiang Li,et al.  Nerve growth factor protects salivary glands from irradiation-induced damage. , 2020, Life sciences.

[10]  S. Ghazizadeh,et al.  Diverse epithelial cell populations contribute to the regeneration of secretory units in injured salivary glands , 2020, Development.

[11]  M. Moore,et al.  CERE-120 Prevents Irradiation-Induced Hypofunction and Restores Immune Homeostasis in Porcine Salivary Glands , 2020, Molecular therapy. Methods & clinical development.

[12]  S. Ghazizadeh,et al.  Diverse Epithelial Cell Populations Contribute to Regeneration of Secretory Units in Injured Salivary Glands , 2020, bioRxiv.

[13]  Y. Chang,et al.  Loss of myoepithelial calponin‐1 characterizes high‐risk ductal carcinoma in situ cases, which are further stratified by T cell composition , 2020, Molecular carcinogenesis.

[14]  L. Calzà,et al.  The pleiotropic molecule NGF regulates the in vitro properties of fibroblasts, keratinocytes and endothelial cells: implications for wound healing. , 2019, American journal of physiology. Cell physiology.

[15]  Henry W. Long,et al.  Perturbed myoepithelial cell differentiation in BRCA mutation carriers and in ductal carcinoma in situ , 2019, Nature Communications.

[16]  M. Hoffman,et al.  Neurturin-containing laminin matrices support innervated branching epithelium from adult epithelial salispheres. , 2019, Biomaterials.

[17]  A. Vissink,et al.  Salivary Gland Hypofunction and Xerostomia in Head and Neck Radiation Patients. , 2019, Journal of the National Cancer Institute. Monographs.

[18]  Yvan Saeys,et al.  A comparison of single-cell trajectory inference methods , 2019, Nature Biotechnology.

[19]  O. Klein,et al.  Diverse progenitor cells preserve salivary gland ductal architecture after radiation-induced damage , 2018, Development.

[20]  David Lumelsky,et al.  Adrb2 controls glucose homeostasis by developmental regulation of pancreatic islet vasculature , 2018, eLife.

[21]  C. Ovitt,et al.  Limited Regeneration of Adult Salivary Glands after Severe Injury Involves Cellular Plasticity. , 2018, Cell reports.

[22]  F. Paulsen,et al.  Myoepithelial cell-driven acini contraction in response to oxytocin receptor stimulation is impaired in lacrimal glands of Sjögren’s syndrome animal models , 2018, Scientific Reports.

[23]  Ryan D. Chow,et al.  Myoepithelial Cells of Submucosal Glands Can Function as Reserve Stem Cells to Regenerate Airways after Injury. , 2018, Cell stem cell.

[24]  N. Barker,et al.  Recent Advances in Lgr5+ Stem Cell Research. , 2018, Trends in cell biology.

[25]  K. Limesand,et al.  aPKCζ-dependent Repression of Yap is Necessary for Functional Restoration of Irradiated Salivary Glands with IGF-1 , 2018, Scientific Reports.

[26]  C. Zheng,et al.  Neurturin Gene Therapy Protects Parasympathetic Function to Prevent Irradiation-Induced Murine Salivary Gland Hypofunction , 2018, Molecular Therapy: Methods & Clinical Development.

[27]  M. Gaete,et al.  Fgf10 and Sox9 are essential for the establishment of distal progenitor cells during mouse salivary gland development , 2017, Development.

[28]  Russell B. Fletcher,et al.  Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics , 2017, bioRxiv.

[29]  K. Hayashi,et al.  The Role of Nerve Growth Factor (NGF) and Its Precursor Forms in Oral Wound Healing , 2017, International journal of molecular sciences.

[30]  R. Burd,et al.  Insulin-Like Growth Factor-1–Mediated DNA Repair in Irradiated Salivary Glands Is Sirtuin-1 Dependent , 2017, Journal of dental research.

[31]  M. Witjes,et al.  Human Salivary Gland Stem Cells Functionally Restore Radiation Damaged Salivary Glands , 2016, Stem cells.

[32]  Megan Troxell,et al.  TUMORIGENESIS AND NEOPLASTIC PROGRESSION Myoepithelial Cell Differentiation Markers in Ductal Carcinoma in Situ Progression , 2015 .

[33]  Piero Carninci,et al.  A draft network of ligand–receptor-mediated multicellular signalling in human , 2015, Nature Communications.

[34]  S. F. Konieczny,et al.  Salivary gland homeostasis is maintained through acinar cell self-duplication. , 2015, Developmental cell.

[35]  S. Demachki,et al.  NGF and P75NTR Gene Expression Is Associated with the Hepatic Fibrosis Stage Due to Viral and Non-Viral Causes , 2015, PloS one.

[36]  M. Diehn,et al.  Neurotrophic factor GDNF promotes survival of salivary stem cells , 2022 .

[37]  B. Lin,et al.  NGF Accelerates Cutaneous Wound Healing by Promoting the Migration of Dermal Fibroblasts via the PI3K/Akt-Rac1-JNK and ERK Pathways , 2014, BioMed research international.

[38]  V. P. Eswarakumar,et al.  Combined KIT and FGFR2b Signaling Regulates Epithelial Progenitor Expansion during Organogenesis , 2013, Stem cell reports.

[39]  S. Leach,et al.  Sympathetic innervation during development is necessary for pancreatic islet architecture and functional maturation. , 2013, Cell reports.

[40]  Fiona Ginty,et al.  Quantitative single cell analysis of cell population dynamics during submandibular salivary gland development and differentiation , 2013, Biology Open.

[41]  M. Hoffman,et al.  Parasympathetic stimulation improves epithelial organ regeneration , 2013, Nature Communications.

[42]  F. Levi-Schaffer,et al.  Chronic Nerve Growth Factor Exposure Increases Apoptosis in a Model of In Vitro Induced Conjunctival Myofibroblasts , 2012, PloS one.

[43]  C. Ovitt,et al.  Ascl3 marks adult progenitor cells of the mouse salivary gland. , 2012, Stem cell research.

[44]  P. Humbert,et al.  Role of neurotrophins on dermal fibroblast survival and differentiation , 2012, Journal of cellular physiology.

[45]  M. P. Hoffman,et al.  Parasympathetic Innervation Maintains Epithelial Progenitor Cells During Salivary Organogenesis , 2010, Science.

[46]  J. Iredale,et al.  p75 neurotrophin receptor signaling regulates hepatic myofibroblast proliferation and apoptosis in recovery from rodent liver fibrosis , 2009, Hepatology.

[47]  H. Kampinga,et al.  Rescue of Salivary Gland Function after Stem Cell Transplantation in Irradiated Glands , 2008, PloS one.

[48]  Benjamin D. Sachs,et al.  p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway , 2007, The Journal of cell biology.

[49]  Melinda Larsen,et al.  FGFR2b signaling regulates ex vivo submandibular gland epithelial cell proliferation and branching morphogenesis , 2005, Development.

[50]  S. Afford,et al.  Hepatic stellate cells express the low affinity nerve growth factor receptor p75 and undergo apoptosis in response to nerve growth factor stimulation. , 2000, The American journal of pathology.

[51]  S. Cohen,et al.  A NERVE GROWTH-STIMULATING FACTOR ISOLATED FROM SNAKE VENOM. , 1956, Proceedings of the National Academy of Sciences of the United States of America.

[52]  M. Hoffman,et al.  ECM and FGF-dependent assay of embryonic SMG epithelial morphogenesis: investigating growth factor/matrix regulation of gene expression during submandibular gland development. , 2009, Methods in molecular biology.