Allergen immunotherapy for IgE‐mediated food allergy: a systematic review and meta‐analysis

The European Academy of Allergy and Clinical Immunology (EAACI) is developing Guidelines for Allergen Immunotherapy (AIT) for IgE‐mediated Food Allergy. To inform the development of clinical recommendations, we sought to critically assess evidence on the effectiveness, safety and cost‐effectiveness of AIT in the management of food allergy.

[1]  J. Fine,et al.  Early oral immunotherapy in peanut‐allergic preschool children is safe and highly effective , 2017, The Journal of allergy and clinical immunology.

[2]  A. Sheikh,et al.  Allergen immunotherapy for IgE-mediated food allergy: protocol for a systematic review , 2016, Clinical and Translational Allergy.

[3]  M. Ibáñez,et al.  Early sustained unresponsiveness after short‐course egg oral immunotherapy: a randomized controlled study in egg‐allergic children , 2015, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[4]  G. Passalacqua,et al.  Oral Immunotherapy for Egg Allergy: A Double-Blind Placebo-Controlled Study, with Postdesensitization Follow-Up. , 2015, The journal of allergy and clinical immunology. In practice.

[5]  D. Gómez-Coronado,et al.  Identification of novel peptide biomarkers to predict safety and efficacy of cow's milk oral immunotherapy by peptide microarray , 2015, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[6]  A. Dubois,et al.  The effects of food allergy on quality of life. , 2015, Chemical immunology and allergy.

[7]  Paul J. Turner,et al.  Increase in anaphylaxis-related hospitalizations but no increase in fatalities: An analysis of United Kingdom national anaphylaxis data, 1992-2012 , 2015, The Journal of allergy and clinical immunology.

[8]  A. Ponsonby,et al.  Administration of a probiotic with peanut oral immunotherapy: A randomized trial. , 2015, The Journal of allergy and clinical immunology.

[9]  A. Muraro,et al.  EAACI Food Allergy and Anaphylaxis Guidelines: diagnosis and management of food allergy , 2014, Allergy.

[10]  A. Sheikh,et al.  Prevalence of common food allergies in Europe: a systematic review and meta‐analysis , 2014, Allergy.

[11]  C. Palmer,et al.  Assessing the efficacy of oral immunotherapy for the desensitisation of peanut allergy in children (STOP II): a phase 2 randomised controlled trial , 2014, The Lancet.

[12]  Stephen J Galli,et al.  Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3). , 2014, The Journal of allergy and clinical immunology.

[13]  A. Sheikh,et al.  The epidemiology of food allergy in Europe: a systematic review and meta‐analysis , 2014, Allergy.

[14]  Jonathan Sterne,et al.  A Cochrane Risk Of Bias AssessmentTool:forNon-RandomizedStudies of Interventions (ACROBAT-NRSI) , 2014 .

[15]  Kirsten Beyer,et al.  A global survey of changing patterns of food allergy burden in children , 2013, The World Allergy Organization journal.

[16]  Y. Hahn,et al.  Increased cow's milk protein-specific IgG4 levels after oral desensitization in 7- to 12-month-old infants. , 2013, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[17]  B. Chipps.  Oral Immunotherapy for Treatment of Egg Allergy in Children , 2013, Pediatrics.

[18]  A. Sheikh,et al.  Effectiveness and safety of orally administered immunotherapy for food allergies: a systematic review and meta-analysis , 2013, British Journal of Nutrition.

[19]  J. Bousquet,et al.  Grading local side effects of sublingual immunotherapy for respiratory allergy: speaking the same language. , 2013, The Journal of allergy and clinical immunology.

[20]  A. Álvarez-Perea,et al.  Specific oral tolerance induction in paediatric patients with persistent egg allergy. , 2013, Allergologia et immunopathologia.

[21]  S. Quirce,et al.  Efficacy and safety of oral desensitization in children with cow's milk allergy according to their serum specific IgE level. , 2013, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[22]  E. Galli,et al.  Oral food desensitization in children with IgE‐mediated hen’s egg allergy: a new protocol with raw hen’s egg , 2013, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[23]  M. Mäkelä,et al.  Milk oral immunotherapy is effective in school‐aged children , 2013, Acta paediatrica.

[24]  S. Miceli Sopo,et al.  Specific oral tolerance induction with raw hen’s egg in children with very severe egg allergy: A randomized controlled trial , 2013, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[25]  A. Henning,et al.  Sublingual immunotherapy for peanut allergy: a randomized, double-blind, placebo-controlled multicenter trial. , 2012, The Journal of allergy and clinical immunology.

[26]  J. Higgins,et al.  Cochrane Handbook for Systematic Reviews of Interventions, Version 5.1.0. The Cochrane Collaboration , 2013 .

[27]  EAACI Food Allergy and Anaphylaxis Guidelines , 2013 .

[28]  A. Sheikh,et al.  Allergen-specific oral immunotherapy for peanut allergy. , 2012, The Cochrane database of systematic reviews.

[29]  H. Schünemann,et al.  Oral immunotherapy for IgE‐mediated cow's milk allergy: a systematic review and meta‐analysis , 2012, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[30]  A. Sheikh,et al.  Oral immunotherapy for the treatment of peanut allergy: systematic review of six case series studies. , 2011, Primary care respiratory journal : journal of the General Practice Airways Group.

[31]  A. Martorell,et al.  Oral desensitization as a useful treatment in 2‐year‐old children with cow's milk allergy , 2011, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[32]  A. Sheikh,et al.  Immunotherapy: The meta-analyses. What have we Learned? , 2011, Immunology and allergy clinics of North America.

[33]  A. Kemper,et al.  A randomized controlled study of peanut oral immunotherapy: clinical desensitization and modulation of the allergic response. , 2011, The Journal of allergy and clinical immunology.

[34]  A. Burks,et al.  Sublingual immunotherapy for peanut allergy: clinical and immunologic evidence of desensitization. , 2011, The Journal of allergy and clinical immunology.

[35]  Aziz Sheikh,et al.  Incidence, prevalence, and trends of general practitioner-recorded diagnosis of peanut allergy in England, 2001 to 2005. , 2011, The Journal of allergy and clinical immunology.

[36]  J. Higgins.  Cochrane handbook for systematic reviews of interventions. Version 5.1.0 [updated March 2011]. The Cochrane Collaboration , 2011 .

[37]  G. Passalacqua,et al.  Oral immunotherapy for cow's milk allergy with a weekly up-dosing regimen: a randomized single-blind controlled study. , 2010, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[38]  G. Toit,et al.  Specific oral tolerance induction in food allergic children: is oral desensitisation more effective than allergen avoidance? , 2010, Archives of Disease in Childhood.

[39]  A. Nowak‐Wegrzyn,et al.  Is oral immunotherapy the cure for food allergies? , 2010, Current opinion in allergy and clinical immunology.

[40]  C. Dupont,et al.  Cow's milk epicutaneous immunotherapy in children: a pilot trial of safety, acceptability, and impact on allergic reactivity. , 2010, The Journal of allergy and clinical immunology.

[41]  P. Bryce,et al.  Immunotherapy in food allergy. , 2010, Immunotherapy.

[42]  R. Lockey,et al.  Speaking the same language: The World Allergy Organization Subcutaneous Immunotherapy Systemic Reaction Grading System. , 2010, The Journal of allergy and clinical immunology.

[43]  V. Giorgio,et al.  Specific oral tolerance induction (SOTI) in pediatric age: Clinical research or just routine practice? , 2010, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[44]  S. Miceli Sopo,et al.  Specific oral tolerance induction for food. A systematic review. , 2010, European annals of allergy and clinical immunology.

[45]  Xingwen Yang,et al.  Specific Oral Tolerance Induction in Food Allergy , 2010 .

[46]  Andreas Radbruch,et al.  Allergy for a lifetime? , 2010, Allergology international : official journal of the Japanese Society of Allergology.

[47]  M. Fernández-Rivas,et al.  Randomized double‐blind, placebo‐controlled trial of sublingual immunotherapy with a Pru p 3 quantified peach extract , 2009, Allergy.

[48]  G. Passalacqua,et al.  A new protocol for specific oral tolerance induction in children with IgE-mediated cow's milk allergy. , 2009, Allergy and asthma proceedings.

[49]  A. Burks,et al.  A randomized, double-blind, placebo-controlled study of milk oral immunotherapy for cow's milk allergy. , 2008, The Journal of allergy and clinical immunology.

[50]  L. Ronfani,et al.  Specific oral tolerance induction in children with very severe cow's milk-induced reactions. , 2008, The Journal of allergy and clinical immunology.

[51]  B. Niggemann,et al.  Specific oral tolerance induction in food allergy in children: efficacy and clinical patterns of reaction , 2007, Allergy.

[52]  H. Sampson,et al.  Peanut allergy: emerging concepts and approaches for an apparent epidemic. , 2007, The Journal of allergy and clinical immunology.

[53]  Anne Muñoz-Furlong,et al.  Further fatalities caused by anaphylactic reactions to food, 2001-2006. , 2007, The Journal of allergy and clinical immunology.

[54]  D. Strachan,et al.  Time trends in allergic disorders in the UK , 2006, Thorax.

[55]  D. Moneret-vautrin,et al.  Oral desensitization in children with milk and egg allergies obtains recovery in a significant proportion of cases. A randomized study in 60 children with cow's milk allergy and 90 children with egg allergy. , 2007, European annals of allergy and clinical immunology.

[56]  Z. Pourpak,et al.  Oral desensitization in children with IgE-mediated cow's milk allergy: a prospective clinical trial , 2007 .

[57]  G. Gasbarrini,et al.  Oral Specific Desensitization in Food-Allergic Children , 2007, Digestive Diseases and Sciences.

[58]  B. Niggemann,et al.  Specific oral tolerance induction in food allergy , 2006, Allergy.

[59]  E. Enrique,et al.  Sublingual immunotherapy for hazelnut food allergy: a randomized, double-blind, placebo-controlled study with a standardized hazelnut extract. , 2005, The Journal of allergy and clinical immunology.

[60]  H. Sampson.  Anaphylaxis and emergency treatment. , 2003, Pediatrics.

[61]  G. Gasbarrini,et al.  Oral desensitizing treatment in food allergy: clinical and immunological results , 2003, Alimentary pharmacology & therapeutics.

[62]  R. Kagan,et al.  The psychological burden of peanut allergy as perceived by adults with peanut allergy and the parents of peanut‐allergic children , 2000, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[63]  G. Gasbarrini,et al.  Food allergy in children: results of a standardized protocol for oral desensitization. , 1998, Hepato-gastroenterology.

[64]  H. Sampson,et al.  Fatal and near-fatal anaphylactic reactions to food in children and adolescents. , 1992, The New England journal of medicine.

[65]  A. Schofield.  A case of egg poisoning , 1908 .