Exposure to polybrominated diphenyl ethers and tetrabromobisphenol A among computer technicians.

This study investigates exposure to polybrominated diphenyl ethers (PBDEs) and tetrabromobisphenol A (TBBPA), which are used as flame retardants in electronic equipment, in a group of technicians with intense computer work. Thirteen PBDE congeners and TBBPA were quantified in serum from 19 computer technicians. Previously investigated groups of hospital cleaners with no computer experience, and clerks working full-time at computer screens were used for comparison. The computer technicians had serum concentrations of BDE-153, BDE-183 and BDE-209 that were five times higher than those reported among hospital cleaners and computer clerks. The median levels observed among the computer technicians were 4.1, 1.3, and 1.6 pmol/g lipid weight, respectively. In contrast, for BDE-47 there was no difference between the computer technicians and the others. BDE-100, BDE-203, and three structurally unidentified octa-BDEs and three nona-BDEs, were present in almost all samples from the computer technicians. Further, TBBPA was detected in 8 out of 10 samples. The levels of BDE-153, BDE-183, and one of the octa-BDEs were positively correlated with duration of computer work among technicians. On a group level an exposure gradient was observed, from the least exposed cleaners to the clerks, and to the highest exposed group of computer technicians. A dose (duration of computer work)-response relationship among computer technicians was demonstrated for some higher brominated PBDE congeners. Thus, it is evident that PBDEs used in computers and electronics, including the fully brominated BDE-209, contaminate the work environment and accumulate in the workers tissues.

[1]  Eva Jakobsson,et al.  Flame retardant exposure: polybrominated diphenyl ethers in blood from Swedish workers. , 1999 .

[2]  I. Meerts,et al.  Potent competitive interactions of some brominated flame retardants and related compounds with human transthyretin in vitro. , 2000, Toxicological sciences : an official journal of the Society of Toxicology.

[3]  L. Hagmar,et al.  Monitoring of Polychlorinated Biphenyls in Human Blood Plasma: Methodological Developments and Influence of Age, Lactation, and Fish Consumption , 1997, Archives of environmental contamination and toxicology.

[4]  J. Duinker,et al.  Complete characterization of polychlorinated biphenyl congeners in commercial Aroclor and Clophen mixtures by multidimensional gas chromatography-electron capture detection , 1989 .

[5]  M. Haugg,et al.  SYNTHESIS AND CHARACTERIZATION OF POLYBROMINATED DIPHENYL ETHERS : UNLABELLED AND RADIOLABELLED TETRA-, PENTA- AND HEXA-BROMODIPHENYL ETHERS , 1996 .

[6]  B. Jansson,et al.  Analysis of tetrabromobisphenol A in a product and environmental samples , 1995 .

[7]  G. Marsh,et al.  Synthesis and Characterization of 32 Polybrominated Diphenyl Ethers , 1999 .

[8]  L. Hagmar,et al.  Influence of the consumption of fatty Baltic Sea fish on plasma levels of halogenated environmental contaminants in Latvian and Swedish men , 2000 .

[9]  A. Bergman,et al.  Flame retardants in indoor air at an electronics recycling plant and at other work environments. , 2001, Environmental science & technology.

[10]  A. Hanberg,et al.  Risk Assessment of Polychlorinated Biphenyls (PCBs) , 1992 .

[11]  R. Tatsukawa,et al.  Identification of the flame retardant tetrabromobisphenol-a in the river sediment and the mussel collected in Osaka , 1983, Bulletin of environmental contamination and toxicology.

[12]  A. Sjödin,et al.  Occupational and dietary exposure to organohalogen substances, with special emphasis on polybrominated diphenyl ethers , 2000 .

[13]  K. Ballschmiter,et al.  Long chain alkyl-polysiloxanes as non-polar stationary phases in capillary gas chromatography , 1993 .

[14]  K. Norén,et al.  Analysis of polybrominated diphenyl ethers in Swedish human milk. A time-related trend study, 1972-1997. , 1999, Journal of toxicology and environmental health. Part A.

[15]  I. Meerts,et al.  In vitro estrogenicity of polybrominated diphenyl ethers, hydroxylated PDBEs, and polybrominated bisphenol A compounds. , 2001, Environmental health perspectives.

[16]  I. Meerts,et al.  Polybrommated diphenyl ethers (PCDs) as Ah-receptor agonists and antagonists. , 1998 .

[17]  Eva Jakobsson,et al.  Developmental neurotoxicity of brominated flame-retardants, polybrominated diphenyl ethers and tetrabromo-bis-phenol A , 1998 .

[18]  R N Stillwell,et al.  Children absorb tris-BP flame retardant from sleepwear: urine contains the mutagenic metabolite, 2,3-dibromopropanol. , 1978, Science.

[19]  S. Jensen,et al.  Extraction and cleanup methods for analysis of phenolic and neutral organohalogens in plasma. , 2000, Journal of analytical toxicology.

[20]  L. Hagmar,et al.  Biological half-lives of polybrominated diphenyl ethers and tetrabromobisphenol a in exposed workers , 2000 .

[21]  Eva Jakobsson,et al.  Gas chromatographic identification and quantification of polybrominated diphenyl ethers in a commercial product, Bromkal 70-5DE , 1998 .

[22]  K. Norén,et al.  Certain organochlorine and organobromine contaminants in Swedish human milk in perspective of past 20-30 years. , 2000, Chemosphere.