Phenotypic connections in surprising places

Surprising correlations between human disease phenotypes are emerging. Recent work now reveals startling phenotype connections between species, which could provide new disease models.

[1]  M. DePamphilis,et al.  HUMAN DISEASE , 1957, The Ulster Medical Journal.

[2]  R. Karp,et al.  Conserved pathways within bacteria and yeast as revealed by global protein network alignment , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[3]  M. Oti,et al.  The modular nature of genetic diseases , 2006, Clinical genetics.

[4]  A. Rzhetsky,et al.  Probing genetic overlap among complex human phenotypes , 2007, Proceedings of the National Academy of Sciences.

[5]  A. Barabasi,et al.  The human disease network , 2007, Proceedings of the National Academy of Sciences.

[6]  Krin A. Kay,et al.  The implications of human metabolic network topology for disease comorbidity , 2008, Proceedings of the National Academy of Sciences.

[7]  A. Barabasi,et al.  Molecular Systems Biology 5; Article number 262; doi:10.1038/msb.2009.16 Citation: Molecular Systems Biology 5:262 , 2022 .

[8]  E. Snitkin,et al.  Genome-wide prioritization of disease genes and identification of disease-disease associations from an integrated human functional linkage network , 2009, Genome Biology.

[9]  Alan F. Scott,et al.  McKusick's Online Mendelian Inheritance in Man (OMIM®) , 2008, Nucleic Acids Res..

[10]  Clara Campas,et al.  Drug repositioning summit: finding new routes to success. , 2009, Drug news & perspectives.

[11]  Kriston L. McGary,et al.  Systematic discovery of nonobvious human disease models through orthologous phenotypes , 2010, Proceedings of the National Academy of Sciences.