Murine genetic models of human disease.

[1]  C J Kemp,et al.  The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice. , 1994, Cancer research.

[2]  C. Purdie,et al.  Tumour incidence, spectrum and ploidy in mice with a large deletion in the p53 gene. , 1994, Oncogene.

[3]  R. Weinberg,et al.  Tumor spectrum analysis in p53-mutant mice , 1994, Current Biology.

[4]  B. Lowell,et al.  Development of obesity in transgenic mice after genetic ablation of brown adipose tissue , 1993, Nature.

[5]  A. Clarke.  Transgenic approaches to cancer biology. , 1993, Current opinion in biotechnology.

[6]  E. Lander,et al.  Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse , 1993, Cell.

[7]  R. Tisch,et al.  Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice , 1993, Nature.

[8]  A. Tobin,et al.  Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes , 1993, Nature.

[9]  J. Mcwhir,et al.  Mice with DNA repair gene (ERCC-1) deficiency have elevated levels of p53, liver nuclear abnormalities and die before weaning , 1993, Nature Genetics.

[10]  L. Donehower,et al.  Spontaneous and carcinogen–induced tumorigenesis in p53–deficient mice , 1993, Nature Genetics.

[11]  E. Rubin,et al.  Protein composition determines the anti-atherogenic properties of HDL in transgenic mice , 1993, Nature.

[12]  P. Laird,et al.  In vivo analysis of Pim-1 deficiency. , 1993, Nucleic acids research.

[13]  D. Housman,et al.  p53-dependent apoptosis modulates the cytotoxicity of anticancer agents , 1993, Cell.

[14]  L. Donehower,et al.  Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors , 1993, Cell.

[15]  E. Wagner,et al.  c-Jun is essential for normal mouse development and hepatogenesis , 1993, Nature.

[16]  L. Donehower,et al.  In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice. , 1993, Oncogene.

[17]  David Housman,et al.  WT-1 is required for early kidney development , 1993, Cell.

[18]  K. Campbell,et al.  Overexpression of dystrophin in transgenic mdx mice eliminates dystrophic symptoms without toxicity , 1993, Nature.

[19]  J. Lotem,et al.  Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents. , 1993, Blood.

[20]  I. Nonaka,et al.  Myogenin gene disruption results in perinatal lethality because of severe muscle defect , 1993, Nature.

[21]  William H. Klein,et al.  Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene , 1993, Nature.

[22]  C. Fisher,et al.  Hyperplasia, hyperkeratosis and benign tumor production in transgenic mice by a targeted v-fos oncogene suggest a role for fos in epidermal differentiation and neoplasia. , 1993, Oncogene.

[23]  G. Pointis,et al.  Expression in transgenic mice of the large T antigen of polyomavirus induces Sertoli cell tumours and allows the establishment of differentiated cell lines. , 1993, Oncogene.

[24]  J. Todd,et al.  Polygenic control of autoimmune diabetes in nonobese diabetic mice , 1993, Nature Genetics.

[25]  J. Qiao,et al.  Atherosclerosis in transgenic mice overexpressing apolipoprotein A-II. , 1993, Science.

[26]  A. Aguzzi,et al.  Mice devoid of PrP are resistant to scrapie , 1993, Cell.

[27]  B. Spiegelman,et al.  Targeted expression of a toxin gene to adipose tissue: transgenic mice resistant to obesity. , 1993, Genes & development.

[28]  K. Marotti,et al.  Severe atherosclerosis in transgenic mice expressing simian cholesteryl ester transfer protein , 1993, Nature.

[29]  Xiaojian Huang,et al.  Induction of type I diabetes by interferon-alpha in transgenic mice. , 1993, Science.

[30]  S. Prusiner,et al.  Propagation of prions with artificial properties in transgenic mice expressing chimeric PrP genes , 1993, Cell.

[31]  J. Loring,et al.  Transgenic mice containing a human heavy chain immunoglobulin gene fragment cloned in a yeast artificial chromosome , 1993, Nature Genetics.

[32]  Richard J Smeyne,et al.  Continuous c-fos expression precedes programmed cell death in vivo , 1993, Nature.

[33]  V. Chapman,et al.  New mdx mutation disrupts expression of muscle and nonmuscle isoforms of dystrophin , 1993, Nature Genetics.

[34]  C. Purdie,et al.  Thymocyte apoptosis induced by p53-dependent and independent pathways , 1993, Nature.

[35]  Scott W. Lowe,et al.  p53 is required for radiation-induced apoptosis in mouse thymocytes , 1993, Nature.

[36]  R. Krumlauf,et al.  Hoxb-4 (Hox-2.6) mutant mice show homeotic transformation of a cervical vertebra and defects in the closure of the sternal rudiments , 1993, Cell.

[37]  W. Shehee,et al.  Lethal thalassemia after insertional disruption of the mouse major adult beta-globin gene. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[38]  A. Bradley,et al.  A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice. , 1993, Genes & development.

[39]  O. Smithies,et al.  Animal models of human genetic diseases. , 1993, Trends in genetics : TIG.

[40]  J. Lawrence,et al.  Germ line transmission of a yeast artificial chromosome spanning the murine alpha 1(I) collagen locus. , 1993, Science.

[41]  G. Kelsey,et al.  A yeast artificial chromosome covering the tyrosinase gene confers copy number-dependent expression in transgenic mice , 1993, Nature.

[42]  L. Green,et al.  Germ-line transmission and expression of a human-derived yeast artificial chromosome , 1993, Nature.

[43]  S. Young,et al.  Targeted modification of the apolipoprotein B gene results in hypobetalipoproteinemia and developmental abnormalities in mice. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[44]  D. Melton,et al.  Production of a model for Lesch–Nyhan syndrome in hypoxanthine phosphoribosyltransferase–deficient mice , 1993, Nature Genetics.

[45]  A Nagy,et al.  Genome manipulation in embryonic stem cells. , 1993, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[46]  J. Seidman,et al.  Progression to diabetes in nonobese diabetic (NOD) mice with transgenic T cell receptors. , 1993, Science.

[47]  P. Briand,et al.  Efficient adenovirus-mediated transfer of a human minidystrophin gene to skeletal muscle of mdx mice , 1993, Nature.

[48]  H. Varmus,et al.  Mouse mammary tumor virus infection accelerates mammary carcinogenesis in Wnt-1 transgenic mice by insertional activation of int-2/Fgf-3 and hst/Fgf-4. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[49]  M. Noble,et al.  Establishment of conditionally immortalized epithelial cell lines from both colon and small intestine of adult H-2Kb-tsA58 transgenic mice. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[50]  S. Gerson,et al.  The prevention of thymic lymphomas in transgenic mice by human O6-alkylguanine-DNA alkyltransferase. , 1993, Science.

[51]  A. Balmain,et al.  Oncogenes and tumour suppressor genes in transgenic mouse models of neoplasia. , 1993, European journal of cancer.

[52]  A. Strasser,et al.  E mu-bcl-2 transgene facilitates spontaneous transformation of early pre-B and immunoglobulin-secreting cells but not T cells. , 1993, Oncogene.

[53]  G. Ciliberto,et al.  Inducible formation of liver tumors in transgenic mice. , 1993, Oncogene.

[54]  J. Vijg,et al.  Transgenic mice as model systems for studying gene mutations in vivo. , 1993, Trends in genetics : TIG.

[55]  M. Capecchi,et al.  Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear. , 1993, Development.

[56]  B. Spiegelman,et al.  Pleiotropic effects of a null mutation in the c-fos proto-oncogene , 1992, Cell.