Characterization of Interdependency Between Intracranial Pressure and Heart Variability Signals: A Causal Spectral Measure and a Generalized Synchronization Measure

Causal coherence and generalized synchronization (GS) index were extracted from beat-to-beat mean intracranial pressure (ICP) and intervals between consecutive normal sinus heart beats (RR interval) that were recorded from 12 patients undergoing normal pressure hydrocephalus diagnosis. Data were organized into two groups including an ICP B-Wave group and a baseline control group. Maximal classic coherence (CC) between ICP and RR interval within [0.04, 0.15] Hz was found to be significantly greater than zero for both B-Wave and control groups with B-Wave CC greater than that of the baseline group. Causal coherence analysis further revealed that feedforward coherence due to RR interval's effect on ICP always exists for both B-Wave and baseline ICP state and no significant difference exists between two groups. On the other hand, feedback coherence from ICP to RR interval was enhanced during the occurrence of B-Wave. This finding regarding the enhanced directional, from ICP to RR interval, coupling between ICP and RR interval was also confirmed by a modified GS measure.

[1]  Carroll,et al.  Synchronization in chaotic systems. , 1990, Physical review letters.

[2]  H. Prabhakar,et al.  Intracranial pressure and haemodynamic changes during the tunnelling phase of ventriculoperitoneal shunt insertion , 2005, European journal of anaesthesiology.

[3]  A. Porta,et al.  Relationship between spectral components of cardiovascular variabilities and direct measures of muscle sympathetic nerve activity in humans. , 1997, Circulation.

[4]  K A Easley,et al.  Cortical cerebral blood flow cycling: anesthesia and arterial blood pressure. , 1995, The American journal of physiology.

[5]  Xiao Hu,et al.  Robust measure for characterizing generalized synchronization. , 2004, Physical review. E, Statistical, nonlinear, and soft matter physics.

[6]  M Miyazaki,et al.  Control of ICP and the cerebrovascular bed by the cholinergic basal forebrain. , 1998, Acta neurochirurgica. Supplement.

[7]  P J Scanlon,et al.  The effects of elevated intracranial pressure on the canine electrocardiogram. , 1987, Journal of electrocardiology.

[8]  Roberto Hornero,et al.  Complex analysis of intracranial hypertension using approximate entropy* , 2006, Critical care medicine.

[9]  W. Berger,et al.  Rhythmic oscillations with a wavelength of 0.5–2 min in transcranial Doppler recordings , 1994, Acta neurologica Scandinavica.

[10]  S Cerutti,et al.  Analysis of short-term oscillations of R-R and arterial pressure in conscious dogs. , 1990, The American journal of physiology.

[11]  Y. Katayama,et al.  Intracranial Pressure Changes in Response to Deep Brain Stimulation in Traumatic Prolonged Coma Patients , 1989 .

[12]  L. Tsimring,et al.  Generalized synchronization of chaos in directionally coupled chaotic systems. , 1995, Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics.

[13]  Luca Faes,et al.  Surrogate data analysis for assessing the significance of the coherence function , 2004, IEEE Transactions on Biomedical Engineering.

[14]  W. Scott,et al.  Heart rate variability after acute traumatic brain injury in children , 2000, Critical care medicine.

[15]  A Malliani,et al.  Presence of vasomotor and respiratory rhythms in the discharge of single medullary neurons involved in the regulation of cardiovascular system. , 1996, Journal of the autonomic nervous system.

[16]  G. Baselli,et al.  Spectral decomposition in multichannel recordings based on multivariate parametric identification , 1997, IEEE Transactions on Biomedical Engineering.

[17]  Raffaello Furlan,et al.  Quantifying the strength of the linear causal coupling in closed loop interacting cardiovascular variability signals , 2002, Biological Cybernetics.

[18]  Masahiro Miyazaki,et al.  The Roles of the Mutual Interaction Between the Locus Coeruleus Complex and the Chorioceptive Pontine Area in the Plateau Wave , 1989 .

[19]  S. Kohno,et al.  Role of autonomic nervous dysfunction in electrocardio-graphic abnormalities and cardiac injury in patients with acute subarachnoid hemorrhage. , 2003, Circulation journal : official journal of the Japanese Circulation Society.

[20]  James McNames,et al.  An automatic beat detection algorithm for pressure signals , 2005, IEEE Transactions on Biomedical Engineering.

[21]  B. Levine,et al.  Spontaneous fluctuations in cerebral blood flow: insights from extended-duration recordings in humans. , 2000, American Journal of Physiology. Heart and Circulatory Physiology.

[22]  R. Quiroga,et al.  Learning driver-response relationships from synchronization patterns. , 1999, Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics.

[23]  P. Reddy,et al.  Respiratory sinus arrhythmia in the denervated human heart. , 1989, Journal of applied physiology.

[24]  U. Dirnagl,et al.  Continuous Measurement of Cerebral Cortical Blood Flow by Laser—Doppler Flowmetry in a Rat Stroke Model , 1989, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[25]  Luca Faes,et al.  Causal transfer function analysis to describe closed loop interactions between cardiovascular and cardiorespiratory variability signals , 2004, Biological Cybernetics.

[26]  Xiao Hu,et al.  Phase Coordination between Intracranial Pressure and Electrocardiogram Signals , 2005, 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference.

[27]  川原 英資,et al.  Role of autonomic nervous dysfunction in electrocardiographic abnormalities and cardiac injury in patients with acute subarachnoid hemorrhage , 2003 .

[28]  L. Auer,et al.  Intracranial pressure oscillations (B-waves) caused by oscillations in cerebrovascular volume , 2005, Acta Neurochirurgica.

[29]  G Baselli,et al.  Assessing baroreflex gain from spontaneous variability in conscious dogs: role of causality and respiration. , 2000, American journal of physiology. Heart and circulatory physiology.

[30]  Luca Faes,et al.  Causal cross-spectral analysis of heart rate and blood pressure variability for describing the impairment of the cardiovascular control in neurally mediated syncope , 2006, IEEE Transactions on Biomedical Engineering.

[31]  Xiao Hu,et al.  Nonlinear analysis of Cerebral hemodynamic and intracranial pressure signals for characterization of autoregulation , 2006, IEEE Transactions on Biomedical Engineering.

[32]  H Troupp,et al.  Continuous recording of the ventricular-fluid pressure in patients with severe acute traumatic brain injury. A preliminary report. , 1965, Journal of neurosurgery.

[33]  J van Aken,et al.  Cardiovascular changes during endoscopic third ventriculostomy. , 2003, Minimally invasive neurosurgery : MIN.

[34]  Piet M. T. Broersen,et al.  Order selection for vector autoregressive models , 2003, IEEE Trans. Signal Process..