论文信息 - An investigation into the deposition of inhalation aerosol particles as a function of air flow rate in a modified ‘Kirk Lung’ †

An investigation into the deposition of inhalation aerosol particles as a function of air flow rate in a modified ‘Kirk Lung’ †

The effect of air flow rate on the deposition of inhalation aerosol particles in a modified ‘Kirk Lung’ has been studied. Two commerical products were used. The amount depositied in the mouthpiece and throat regions decreases with increasing flow rate. The amount in the collector rises to maximum of approximately 50%. This material represents the therapeutically available portion. Such an apparatus would be useful for routine quality control of the size distribution ratios for inhalation aerosol particles.

[1] G. G. Stokes. "J." , 1890, The New Yale Book of Quotations.

[2] T. Hatch,et al. Pulmonary Deposition and Retention of Inhaled Aerosols , 1964 .

[3] H. Davies,et al. Evaluation of a breath actuated pressurized aerosol , 1976, Clinical allergy.

[4] W. Kirk. In vitro method of comparing clouds produced from inhalation aerosols for efficiency in penetration of airways. , 1972, Journal of pharmaceutical sciences.

[5] H. Landahl. On the removal of air-borne droplets by the human respiratory tract: I. The lung , 1950 .

[6] Stephen B. Sulavik,et al. Pulmonary Deposition and Retention of Inhaled Aerosols , 1964, The Yale Journal of Biology and Medicine.