Incidence of ovarian cancer among alcoholic women: A cohort study in Sweden

Linkage of nationwide databases in Sweden allowed us to evaluate the incidence of ovarian cancer among 36,856 women diagnosed with alcoholism between 1965 and 1994. Mean duration of follow‐up was 9.6 years, for a total of 317,518 person‐years at risk. The expected number of cases of ovarian cancer was calculated by multiplying the number of person‐years by 5‐year age group and calendar year‐specific incidence rates of ovarian cancer in Sweden. The effect measure was the standardized incidence ratio (SIR), with 95% confidence intervals (CIs). Our results indicate an overall deficit of cases of ovarian cancer of about 14% among women with a diagnosis of alcoholism. This deficit is particularly strong and statistically significant among alcoholic women younger than 60 years (SIR = 0.76, 95% CI 0.58–1.00). This deficit is compatible with the reported reduction of gonadotrophin levels among alcoholic women younger than 60 years and with the hypothesis invoking these gonadotrophins in the etiology of ovarian cancer. © 2001 Wiley‐Liss, Inc.

[1]  L. Holmberg,et al.  Alcoholism and cancer risk: a population-based cohort study , 1992, Cancer Causes & Control.

[2]  H. Adami,et al.  Alcohol and breast cancer risk: the alcoholism paradox , 2000, British Journal of Cancer.

[3]  H. Risch.  Hormonal etiology of epithelial ovarian cancer, with a hypothesis concerning the role of androgens and progesterone. , 1999, Journal of the National Cancer Institute.

[4]  S. Nilsson,et al.  Hormonal aspects of epithelial ovarian cancer: review of epidemiological evidence , 1998, Clinical endocrinology.

[5]  G. Chenevix-Trench,et al.  Relationship between number of ovulatory cycles and accumulation of mutant p53 in epithelial ovarian cancer. , 1998, Journal of the National Cancer Institute.

[6]  B. Macmahon,et al.  Epidemiology Principles and Methods (2nd edition) , 1997 .

[7]  F. Petraglia,et al.  Difference of LH and FSH secretory characteristics and degree of concordance between postmenopausal and aging women. , 1997, Maturitas.

[8]  W. Willett,et al.  A prospective study of reproductive factors and risk of epithelial ovarian cancer , 1995, Cancer.

[9]  H. Adami,et al.  Parity, age at first childbirth, and risk of ovarian cancer , 1994, The Lancet.

[10]  D. Trichopoulos,et al.  Reproductive variables, tobacco, ethanol, coffee and somatometry as risk factors for ovarian cancer , 1993, International journal of cancer.

[11]  R. Kruitwagen,et al.  Ovarian stimulation and granulosa-cell tumour , 1993, The Lancet.

[12]  A. Whittemore,et al.  Characteristics relating to ovarian cancer risk: collaborative analysis of 12 US case-control studies. II. Invasive epithelial ovarian cancers in white women. Collaborative Ovarian Cancer Group. , 1992, American journal of epidemiology.

[13]  C. la Vecchia,et al.  Alcohol and epithelial ovarian cancer. , 1992, Journal of clinical epidemiology.

[14]  D. V. van Thiel,et al.  Hormonal status of postmenopausal women with alcohol‐induced cirrhosis: Further findings and a review of the literature , 1992, Hepatology.

[15]  S. Lowry,et al.  Incessant ovulation and ovarian cancer , 1991, The Lancet.

[16]  C. la Vecchia.  Nutritional factors and cancers of the breast, endometrium and ovary. , 1989, European journal of cancer & clinical oncology.

[17]  P. Prior.  Long-term cancer risk in alcoholism. , 1988, Alcohol and alcoholism.

[18]  M. Gwinn,et al.  Alcohol consumption and ovarian cancer risk. , 1986, American journal of epidemiology.

[19]  B. Stadel.  The etiology and prevention of ovarian cancer , 1975 .

[20]  M F Fathalla,et al.  Incessant ovulation--a factor in ovarian neoplasia? , 1971, Lancet.

[21]  B. Macmahon,et al.  Epidemiology: Principles and Methods , 1970 .

[22]  J BERKSON,et al.  Limitations of the application of fourfold table analysis to hospital data. , 1946, Biometrics.