SARS-CoV-2 viral load is associated with increased disease severity and mortality

Michael D Healy | Kelsey K. Finn | David A. Drew | B. Walker | K. Flaherty | E. Karlson | D. Kuritzkes | G. Alter | M. Lichterfeld | D. Lingwood | S. Pillai | D. Drew | C. O’Callaghan | David Golan | A. Balazs | D. Hanidziar | E. Ryan | A. Tsibris | Jonathan Z. Li | M. Desjardins | S. Fischinger | C. Atyeo | Julia Bals | Hang Liu | Grace Holland | R. Baron | L. Baden | M. Dougan | A. Piechocka-Trocha | Yuting Lu | S. Weiss | Y. Bartsch | Katherine T. Broderick | J. Boucau | Pilar García-Broncano | M. Barbash | M. Choudhary | Xiaodong Lian | Jesse Fajnzylber | K. Sheppard | J. Flannery | Daniel P. Worrall | N. Jilg | Yijia Li | A. Sharpe | A. Griffin | Xiaoming Sun | A. Zhu | E. Gettings | Xu Yu | Kevin B. Einkauf | Joshua M. Chevalier | J. Regan | Kendyll Coxen | H. Corry | C. Hartana | Colline Wong | A. Rosenthal | Elizabeth Gillespie | R. Chishti | K. Lefteri | Matt Osborn | Chenyan Jiang | P. Kaplonek | Marshall Karpell | Jinqing Liu | Ngoc L. Ly | Yelizaveta Rassadkina | Kyra W. Seiger | Libera Sessa | S. Shin | Weiwei Sun | Hannah Ticheli | B. Etemad | P. Allen | L. Novack | E. Lam | C. Sharr | J. Braley | R. McNamara | S. Nelson | Diane Antille | Siobhan Boyce | Karen Branch | J. Carney | G. Daley | Ashley Elliman | Liz Fedirko | S. Grimmel | Kathleen A. Grinke | K. Hall | H. Heller | Deborah Henault | Chantal Kayitesi | V. LaValle | Sarah Luthern | J. Marchewka | Brittani Martino | Ilan Millstrom | Noah Miranda | Christian Nambu | Marjorie Noone | Christine Ommerborn | Lois Chris Pacheco | Nicole Phan | F. A. Porto | Alexandra Reissis | Francis Ruzicka | K. Selleck | Sue Slaughenhaupt | Elizabeth Suschana | Vivine Wilson | K. Armstrong | Ashlin R. Michell | H. Jordan | Jonathan K. Fallon | Francoise F. Giguel | Andrew T. Chan | Betelihem A. (Betty) Patrick Diane Alejandro Julia Max Yanni Abayneh Allen Antille Balazs Bals Barba | B. A. Abayneh | Navin Chowdhury | T. Cordwell | Susan P Davidson | Lauren Donahue | Sampson Elizabeth | Pamela J Forde | Kirsten Goodman | Kelly Lopez | Maureen MacGowan | Karen Magispoc | Nishant Singh | Elizabeth (Lizzie) Suschana | Opeyemi Talabi | Athe Tsibris | Pilar Garcia-Broncano | Kristina Lefteri | Michaël Desjardins | Rida Chishti | Hannah Jordan | Sally A. Shin | Nishant K. Singh

[1]  L. Dodd,et al.  Remdesivir for the Treatment of Covid-19 - Preliminary Report. Reply. , 2020, The New England journal of medicine.

[2]  A. Basu,et al.  Faculty Opinions recommendation of Post-mortem examination of COVID19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings of lungs and other organs suggesting vascular dysfunction. , 2020, Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature.

[3]  L. Dodd,et al.  Remdesivir for the Treatment of Covid-19 — Final Report , 2020, The New England journal of medicine.

[4]  Axel Haverich,et al.  Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19. , 2020, The New England journal of medicine.

[5]  Victor G. Puelles,et al.  Multiorgan and Renal Tropism of SARS-CoV-2 , 2020, The New England journal of medicine.

[6]  K. Mertz,et al.  Postmortem examination of COVID‐19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings in lungs and other organs suggesting vascular dysfunction , 2020, Histopathology.

[7]  R. Schwartz,et al.  Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19 , 2020, Cell.

[8]  Yi Wang,et al.  Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial , 2020, The Lancet.

[9]  Thomas J Oxley,et al.  Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young , 2020, The New England journal of medicine.

[10]  P. Navalesi,et al.  COVID-19-Related Severe Hypercoagulability in Patients Admitted to Intensive Care Unit for Acute Respiratory Failure , 2020, Thrombosis and Haemostasis.

[11]  Holger Moch,et al.  Endothelial cell infection and endotheliitis in COVID-19 , 2020, The Lancet.

[12]  L. Menicanti,et al.  The procoagulant pattern of patients with COVID‐19 acute respiratory distress syndrome , 2020, Journal of Thrombosis and Haemostasis.

[13]  M. Netea,et al.  Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure , 2020, Cell Host & Microbe.

[14]  Yutao Guo,et al.  COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-Up , 2020, Journal of the American College of Cardiology.

[15]  Jun Liu,et al.  Factors associated with prolonged viral RNA shedding in patients with COVID-19 , 2020, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[16]  Xiaowei Yan,et al.  Coagulopathy and Antiphospholipid Antibodies in Patients with Covid-19 , 2020, The New England journal of medicine.

[17]  P. Vollmar,et al.  Virological assessment of hospitalized patients with COVID-2019 , 2020, Nature.

[18]  H. Goossens,et al.  Lower respiratory tract infection in the community: associations between viral aetiology and illness course , 2020, Clinical Microbiology and Infection.

[19]  Yi Feng,et al.  The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2 , 2020, Cardiovascular research.

[20]  O. Tsang,et al.  Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study , 2020, The Lancet Infectious Diseases.

[21]  Eric H. Y. Lau,et al.  Temporal dynamics in viral shedding and transmissibility of COVID-19 , 2020, Nature Medicine.

[22]  Ruiyun Li,et al.  Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV-2) , 2020, Science.

[23]  M. Lipsitch,et al.  Estimating clinical severity of COVID-19 from the transmission dynamics in Wuhan, China , 2020, Nature Medicine.

[24]  R. Lu,et al.  Detection of SARS-CoV-2 in Different Types of Clinical Specimens. , 2020, JAMA.

[25]  Dong Men,et al.  Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely correlated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients , 2020, medRxiv.

[26]  K. Yuen,et al.  Clinical Characteristics of Coronavirus Disease 2019 in China , 2020, The New England journal of medicine.

[27]  J. Routy,et al.  Clinical outcome after lipectomy in the management of patients with human immunodeficiency virus-associated dorsocervical fat accumulation , 2019, Medicine.

[28]  Kuender D Yang,et al.  Correlation of Pandemic (H1N1) 2009 Viral Load with Disease Severity and Prolonged Viral Shedding in Children , 2010, Emerging infectious diseases.

[29]  J. Sung,et al.  Viral Loads and Duration of Viral Shedding in Adult Patients Hospitalized with Influenza , 2009, The Journal of infectious diseases.

[30]  Pan‐Chyr Yang,et al.  Detection of Severe Acute Respiratory Syndrome Coronavirus RNA in Plasma during the Course of Infection , 2005, Journal of Clinical Microbiology.

[31]  P. Woo,et al.  Viral Loads in Clinical Specimens and SARS Manifestations , 2004, Emerging infectious diseases.

[32]  G. Navis,et al.  Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis , 2004, The Journal of pathology.

[33]  Stuart T. Nichol,et al.  Rapid Diagnosis of Ebola Hemorrhagic Fever by Reverse Transcription-PCR in an Outbreak Setting and Assessment of Patient Viral Load as a Predictor of Outcome , 2004, Journal of Virology.

[34]  J. Sung,et al.  Viral Replication in the Nasopharynx Is Associated with Diarrhea in Patients with Severe Acute Respiratory Syndrome , 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[35]  J. Sung,et al.  Detection of SARS coronavirus in plasma by real-time RT-PCR. , 2003, The New England journal of medicine.

[36]  John W. Mellors,et al.  New Real-Time Reverse Transcriptase-Initiated PCR Assay with Single-Copy Sensitivity for Human Immunodeficiency Virus Type 1 RNA in Plasma , 2003, Journal of Clinical Microbiology.

[37]  K. Harada,et al.  Direct Observation of Vortex Dynamics in Superconducting Films with Regular Arrays of Defects , 1996, Science.

[38]  D. R. Kuritzkes,et al.  HIV viral load markers in clinical practice , 1996, Nature Medicine.

[39]  John W. Mellors,et al.  Prognosis in HIV-1 Infection Predicted by the Quantity of Virus in Plasma , 1996, Science.

[40]  Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV2) , 2020 .

[41]  J. Zwischenberger,et al.  Severe respiratory failure. , 2001, The Annals of thoracic surgery.