Anatomic Customization of Root-Analog Dental Implants With Cone-Beam CT and CAD/CAM Fabrication: A Cadaver-Based Pilot Evaluation.

Existing root-analog dental implant systems have no standardized protocols regarding retentive design, surface manipulation, or prosthetic attachment design relative to the site's unique anatomy. Historically, existing systems made those design choices arbitrarily. For this report, strategies were developed that deliberately reference the adjacent anatomy, implant and restorable path of draw, and bone density for implant and retentive design. For proof of concept, dentate arches from human cadavers were scanned using cone-beam computed tomography and then digitally modeled. Teeth of interest were virtually extracted and manipulated via computer-aided design to generate root-analog implants from zirconium. We created a stepwise protocol for analyzing and developing the implant sites, implant design and retention, and prosthetic emergence and connection all from the pre-op cone-beam data. Root-analog implants were placed at the time of extraction and examined radiographically and mechanically concerning ideal fit and stability. This study provides proof of concept that retentive root-analog implants can be produced from cone-beam data while improving fit, retention, safety, esthetics, and restorability when compared to the existing protocols. These advancements may provide the critical steps necessary for clinical relevance and success of immediately placed root-analog implants. Additional studies are necessary to validate the model prior to clinical trial.

[1]  Su-Gwan Kim,et al.  Reliability of 2 Implant Stability Measuring Methods in Assessment of Various Periimplant Bone Loss: An In Vitro Study With the Periotest and Osstell Mentor , 2014, Implant dentistry.

[2]  U. Lekholm,et al.  Influence of initial implant mobility on the integration of titanium implants. An experimental study in rabbits. , 1996, Clinical oral implants research.

[3]  A. Piattelli,et al.  Bone response to zirconia ceramic implants: an experimental study in rabbits. , 2003, The Journal of oral implantology.

[4]  Bassam Hassan,et al.  Designing a novel dental root analogue implant using cone beam computed tomography and CAD/CAM technology. , 2013, Clinical oral implants research.

[5]  Heng-Li Huang,et al.  Relationship of three-dimensional bone-to-implant contact to primary implant stability and peri-implant bone strain in immediate loading: microcomputed tomographic and in vitro analyses. , 2013, The International journal of oral & maxillofacial implants.

[6]  M Hodosh,et al.  The dental polymer implant concept. , 1969, The Journal of prosthetic dentistry.

[7]  A. Kocher,et al.  Root analog zirconia implants: true anatomical design for molar replacement--a case report. , 2011, The International journal of periodontics & restorative dentistry.

[8]  J R Strub,et al.  Custom-made root analogue titanium implants placed into extraction sockets. An experimental study in monkeys. , 1997, Clinical oral implants research.

[9]  A. Kocher,et al.  Immediate, non-submerged, root-analogue zirconia implant in single tooth replacement. , 2008, International journal of oral and maxillofacial surgery.

[10]  M. Wolkewitz,et al.  The effects of cyclic loading and preparation on the fracture strength of zirconium-dioxide implants: an in vitro investigation. , 2011, Clinical oral implants research.

[11]  E. Keller,et al.  Endosseous implant placement immediately following dental extraction and alveoloplasty: preliminary report with 6-year follow-up. , 1992, The International journal of oral & maxillofacial implants.

[12]  M. Wolkewitz,et al.  Alumina-reinforced zirconia implants: survival rate and fracture strength in a masticatory simulation trial. , 2010, Clinical oral implants research.

[13]  N. D’Silva,et al.  Implant compression necrosis: current understanding and case report. , 2009, Journal of periodontology.

[14]  H. Schliephake,et al.  Osseointegration of endodontic endosseous cones: zirconium oxide vs titanium. , 2000, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[15]  Francesco Guido Mangano,et al.  Custom-made, root-analogue direct laser metal forming implant: a case report , 2012, Lasers in Medical Science.

[16]  Walter Renne,et al.  Predicting marginal fit of CAD/CAM crowns based on the presence or absence of common preparation errors. , 2012, The Journal of prosthetic dentistry.

[17]  Bassam Hassan,et al.  Accuracy of preemptively constructed, cone beam CT-, and CAD/CAM technology-based, individual Root Analogue Implant technique: an in vitro pilot investigation. , 2014, Clinical oral implants research.

[18]  D Lundgren,et al.  Healing-in of root analogue titanium implants placed in extraction sockets. An experimental study in the beagle dog. , 1992, Clinical oral implants research.

[19]  Su-Gwan Kim,et al.  Clinical study of the relationship between implant stability measurements using Periotest and Osstell mentor and bone quality assessment. , 2012, Oral surgery, oral medicine, oral pathology and oral radiology.

[20]  A. Al-Ahmad,et al.  Biofilm formation and composition on different implant materials in vivo. , 2010, Journal of biomedical materials research. Part B, Applied biomaterials.

[21]  D. Tarnow,et al.  Human histologic verification of osseointegration of an immediate implant placed into a fresh extraction socket with excessive gap distance without primary flap closure, graft, or membrane: a case report. , 2011, The International journal of periodontics & restorative dentistry.

[22]  K. Gröndahl,et al.  Marginal bone loss at implants: a retrospective, long-term follow-up of turned Brånemark System implants. , 2009, Clinical implant dentistry and related research.

[23]  A. Kocher,et al.  Immediate, non-submerged, root-analogue zirconia implants placed into single-rooted extraction sockets: 2-year follow-up of a clinical study. , 2009, International journal of oral and maxillofacial surgery.

[24]  R. Kohal,et al.  One-piece zirconia oral implants: one-year results from a prospective cohort study. 1. Single tooth replacement. , 2012, Journal of clinical periodontology.

[25]  G. Swennen,et al.  Cone-beam computerized tomography (CBCT) imaging of the oral and maxillofacial region: a systematic review of the literature. , 2009, International journal of oral and maxillofacial surgery.

[26]  David Anssari Moin,et al.  A Patient Specific Biomechanical Analysis of Custom Root Analogue Implant Designs on Alveolar Bone Stress: A Finite Element Study , 2016, International journal of dentistry.

[27]  L. Sennerby,et al.  Bone tissue responses to surface-modified zirconia implants: A histomorphometric and removal torque study in the rabbit. , 2005, Clinical implant dentistry and related research.

[28]  G. Raghoebar,et al.  Long-term evaluation of hollow screw and hollow cylinder dental implants: clinical and radiographic results after 10 years. , 2006, Journal of periodontology.

[29]  A. Kocher,et al.  Immediate, single stage, truly anatomic zirconia implant in lower molar replacement: a case report with 2.5 years follow-up. , 2011, International journal of oral and maxillofacial surgery.