Circuits, Currents, Kirchhoff, and Maxwell

Electricity flows in circuits that bring us power and information. The current flow in circuits is defined by the Maxwell equations that are as exact and universal as any in science. The Maxwell-Ampere law defines the source of the magnetic field as a current. In a vacuum, like that between stars, there are no charges to carry that current. In a vacuum, the source of the magnetic field is the displacement current, \(\varepsilon_0\ \partial\mathbf{E}/\partial t\). Inside matter, the source of the magnetic field is the flux of charge added to the displacement current. This total current obeys a version of Kirchhoff’s current law that is implied by the mathematics of the Maxwell equations, and therefore is as universal and exact as they are. Kirchhoff's laws provide a useful coarse graining of the Maxwell equations that avoids calculating the Coulombic interactions of \({10}^{23}\) charges yet provide sufficient information to design the integrated circuits of our computers. Kirchhoff's laws are exact, as well as coarse grained because they are a mathematical consequence of the Maxwell equations, without assumption or further physical content. In a series circuit, the coupling in Kirchhoff’s law makes the total current exactly equal everywhere at any time. The Maxwell equations provide just the forces needed to move atomic charges so the total currents in Kirchhoff’s law are equal for any mechanism of charge movement. Those movements couple processes for any physical mechanism of charge movement. In biology, Kirchhoff coupling is an important part of membrane transport and enzyme function. For example, it helps the membrane enzymes cytochrome c oxidase and ATP-synthase produce ATP, the biological store of chemical energy.

[1]  Jens Lienig,et al.  Fundamentals of Layout Design for Electronic Circuits , 2020 .

[2]  D. Ferry,et al.  Dynamics of Current, Charge and Mass , 2017, 1708.07400.

[3]  R. Eisenberg,et al.  Continuum Gating Current Models Computed with Consistent Interactions , 2017, Biophysical journal.

[4]  R. Eisenberg Mass Action and Conservation of Current , 2015, 1502.07251.

[5]  Arieh Warshel,et al.  Multiscale modeling of biological functions: from enzymes to molecular machines (Nobel Lecture). , 2014, Angewandte Chemie.

[6]  R. E. Lagos,et al.  Charged Brownian particles: Kramers and Smoluchowski equations and the hydrothermodynamical picture , 2011, 1305.0487.

[7]  E. Joffe,et al.  Grounds for Grounding , 2009 .

[8]  John E. Ayers,et al.  Digital Integrated Circuits , 2009 .

[9]  M. Langner,et al.  Insight into the origins of the barrier-less knock-on conduction in the KcsA channel: molecular dynamics simulations and ab initio calculations. , 2007, Physical chemistry chemical physics : PCCP.

[10]  Ron Larson The value of Einstein’s mistakes , 2006 .

[11]  Peter Hänggi,et al.  Introduction: 100 years of Brownian motion. , 2005, Chaos.

[12]  Francisco Bezanilla,et al.  Voltage Sensor Movements , 2002, The Journal of general physiology.

[13]  F Bezanilla,et al.  The voltage sensor in voltage-dependent ion channels. , 2000, Physiological reviews.

[14]  R. Landauer Mesoscopic noise: Common sense view , 1996 .

[15]  R. S. Eisenberg,et al.  Computing the Field in Proteins and Channels , 2010, 1009.2857.

[16]  R. Eisenberg,et al.  A Singular Perturbation Analysis of Induced Electric Fields in Nerve Cells , 1971 .

[17]  F. Bezanilla,et al.  Time course of the sodium permeability change during a single membrane action potential , 1970, The Journal of physiology.

[18]  R. Landauer Electrical resistance of disordered one-dimensional lattices , 1970 .

[19]  F. Bezanilla,et al.  Time course of the sodium influx in squid giant axon during a single voltage clamp pulse , 1970, The Journal of physiology.

[20]  F. Bezanilla,et al.  Sodium influxes in internally perfused squid giant axon during voltage clamp , 1969, The Journal of physiology.

[21]  A. Hodgkin,et al.  The influence of calcium on sodium efflux in squid axons , 1969, The Journal of physiology.

[22]  A. Hodgkin,et al.  The rate of formation and turnover of phosphorus compounds in squid giant axons , 1964, The Journal of physiology.

[23]  A. Hodgkin,et al.  The effects of changes in internal ionic concentrations on the electrical properties of perfused giant axons , 1962, The Journal of physiology.

[24]  A. Hodgkin,et al.  The effects of injecting ‘energy‐rich’ phosphate compounds on the active transport of ions in the giant axons of Loligo , 1960, The Journal of physiology.

[25]  A. Hodgkin,et al.  Partial inhibition of the active transport of cations in the giant axons of Loligo , 1960, The Journal of physiology.

[26]  A. Hodgkin,et al.  The potassium permeability of a giant nerve fibre , 1955, The Journal of physiology.

[27]  A. Hodgkin,et al.  Measurement of current‐voltage relations in the membrane of the giant axon of Loligo , 1952, The Journal of physiology.

[28]  A. A. Maryott,et al.  Dielectric Constants of Aqueous Solutions of Dextrose and Sucrose , 1950 .

[29]  A. Hodgkin Evidence for electrical transmission in nerve , 1937, The Journal of physiology.

[30]  W. Sutherland,et al.  LXXV. A dynamical theory of diffusion for non-electrolytes and the molecular mass of albumin , 1905 .

[31]  R. Brown XXVII. A brief account of microscopical observations made in the months of June, July and August 1827, on the particles contained in the pollen of plants; and on the general existence of active molecules in organic and inorganic bodies , 1828 .

[32]  Z. Schuss Theory and Applications of Stochastic Processes , 2010 .

[33]  A. Hodgkin,et al.  A quantitative description of membrane current and its application to conduction and excitation in nerve , 1990, Bulletin of mathematical biology.

[34]  JOHN EVANS,et al.  The Royal Society , 1894, Nature.

[35]  W. Thomson On the Theory of the Electric Telegraph , 2022 .