Orm family proteins mediate sphingolipid homeostasis

[1]  D. Clayton,et al.  Genome-wide association study and meta-analysis finds over 40 loci affect risk of type 1 diabetes , 2009, Nature Genetics.

[2]  K. Dewar,et al.  Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease. , 2009, American journal of human genetics.

[3]  Ruedi Aebersold,et al.  Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis. , 2009, Genes & development.

[4]  J. Brouwers,et al.  Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER , 2009, The Journal of cell biology.

[5]  K. Siminovitch,et al.  Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants. , 2009, The New England journal of medicine.

[6]  Christer S. Ejsing,et al.  Segregation of sphingolipids and sterols during formation of secretory vesicles at the trans-Golgi network , 2009, The Journal of cell biology.

[7]  S. London,et al.  Genetic variation in ORM1‐like 3 (ORMDL3) and gasdermin‐like (GSDML) and childhood asthma , 2009, Allergy.

[8]  L. Cowart,et al.  Modulation of Sphingolipid Metabolism by the Phosphatidylinositol-4-phosphate Phosphatase Sac1p through Regulation of Phosphatidylinositol in Saccharomyces cerevisiae* , 2009, Journal of Biological Chemistry.

[9]  E. Sondik,et al.  Status of Childhood Asthma in the United States, 1980–2007 , 2009, Pediatrics.

[10]  R. Hampton,et al.  Protein quality control as a strategy for cellular regulation: lessons from ubiquitin-mediated regulation of the sterol pathway. , 2009, Chemical reviews.

[11]  Christer S. Ejsing,et al.  Global analysis of the yeast lipidome by quantitative shotgun mass spectrometry , 2009, Proceedings of the National Academy of Sciences.

[12]  Klaus Natter,et al.  Cdk1/Cdc28-dependent activation of the major triacylglycerol lipase Tgl4 in yeast links lipolysis to cell-cycle progression. , 2009, Molecular cell.

[13]  P. Mayinger,et al.  SAC1 lipid phosphatase and growth control of the secretory pathway. , 2009, Molecular bioSystems.

[14]  A. Link,et al.  Insig regulates HMG-CoA reductase by controlling enzyme phosphorylation in fission yeast. , 2008, Cell metabolism.

[15]  J. Bousquet,et al.  Effect of 17q21 variants and smoking exposure in early-onset asthma. , 2008, The New England journal of medicine.

[16]  R. Proia,et al.  The alliance of sphingosine-1-phosphate and its receptors in immunity , 2008, Nature Reviews Immunology.

[17]  Judy H. Cho,et al.  Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease , 2008, Nature Genetics.

[18]  Sarah Spiegel,et al.  Cross-talk at the crossroads of sphingosine-1-phosphate, growth factors, and cytokine signaling. , 2008, Journal of lipid research.

[19]  E. Burchard,et al.  ORMDL3 gene is associated with asthma in three ethnically diverse populations. , 2008, American journal of respiratory and critical care medicine.

[20]  C. Palmer,et al.  A polymorphism controlling ORMDL3 expression is associated with asthma that is poorly controlled by current medications. , 2008, The Journal of allergy and clinical immunology.

[21]  S. Spiegel,et al.  The role of sphingosine-1-phosphate and its receptors in asthma. , 2008, Drug news & perspectives.

[22]  D. Vercelli,et al.  Discovering susceptibility genes for asthma and allergy , 2008, Nature Reviews Immunology.

[23]  Ted Powers,et al.  Regulation of ceramide biosynthesis by TOR complex 2. , 2008, Cell metabolism.

[24]  Yusuf A. Hannun,et al.  Principles of bioactive lipid signalling: lessons from sphingolipids , 2008, Nature Reviews Molecular Cell Biology.

[25]  S. Cuzzocrea,et al.  Ceramide: a Key Signaling Molecule in a Guinea Pig Model of Allergic Asthmatic Response and Airway Inflammation , 2008, Journal of Pharmacology and Experimental Therapeutics.

[26]  Y. Hannun,et al.  Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide , 2007, Nature.

[27]  Gonçalo R. Abecasis,et al.  Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma , 2007, Nature.

[28]  T. Hornemann,et al.  Is the mammalian serine palmitoyltransferase a high-molecular-mass complex? , 2007, The Biochemical journal.

[29]  K. Hanada,et al.  Interorganelle Trafficking of Ceramide Is Regulated by Phosphorylation-dependent Cooperativity between the PH and START Domains of CERT* , 2007, Journal of Biological Chemistry.

[30]  Thomas Strahl,et al.  Synthesis and function of membrane phosphoinositides in budding yeast, Saccharomyces cerevisiae. , 2007, Biochimica et biophysica acta.

[31]  L. Obeid,et al.  Yeast sphingolipids: recent developments in understanding biosynthesis, regulation, and function. , 2007, Biochimica et biophysica acta.

[32]  C. Oh,et al.  Regulation of long chain unsaturated fatty acid synthesis in yeast. , 2007, Biochimica et biophysica acta.

[33]  M. Lathrop,et al.  The gene encoding adipose triglyceride lipase (PNPLA2) is mutated in neutral lipid storage disease with myopathy , 2007, Nature Genetics.

[34]  R. Lester,et al.  Functions and metabolism of sphingolipids in Saccharomyces cerevisiae. , 2006, Progress in lipid research.

[35]  M. Idzko,et al.  Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function. , 2006, The Journal of clinical investigation.

[36]  A. Llebaria,et al.  Inhibitors of sphingolipid metabolism enzymes. , 2006, Biochimica et biophysica acta.

[37]  A. Parsons,et al.  The Phosphatidylinositol 4,5-Biphosphate and TORC2 Binding Proteins Slm1 and Slm2 Function in Sphingolipid Regulation , 2006, Molecular and Cellular Biology.

[38]  E. Kinoshita,et al.  Phosphate-binding Tag, a New Tool to Visualize Phosphorylated Proteins*S , 2006, Molecular & Cellular Proteomics.

[39]  Sean R. Collins,et al.  Exploration of the Function and Organization of the Yeast Early Secretory Pathway through an Epistatic Miniarray Profile , 2005, Cell.

[40]  Christopher J. R. Loewen,et al.  Phospholipid Metabolism Regulated by a Transcription Factor Sensing Phosphatidic Acid , 2004, Science.

[41]  Satoshi Yasuda,et al.  Molecular machinery for non-vesicular trafficking of ceramide , 2003, Nature.

[42]  K. Hanada,et al.  Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism. , 2003, Biochimica et biophysica acta.

[43]  Chang-Su Lim.  All about proteins , 2002, Genome Biology.

[44]  G. Marfany,et al.  ORMDL proteins are a conserved new family of endoplasmic reticulum membrane proteins , 2002, Genome Biology.

[45]  R. Lester,et al.  High-performance liquid chromatography analysis of molecular species of sphingolipid-related long chain bases and long chain base phosphates in Saccharomyces cerevisiae after derivatization with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate. , 2001, Analytical biochemistry.

[46]  S. Spiegel,et al.  Sphingosine 1‐phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[47]  A. Burlingame,et al.  In‐Gel Digestion of Proteins for MALDI‐MS Fingerprint Mapping , 1998, Current protocols in protein science.

[48]  K. Gable,et al.  Tsc3p Is an 80-Amino Acid Protein Associated with Serine Palmitoyltransferase and Required for Optimal Enzyme Activity* , 2000, The Journal of Biological Chemistry.

[49]  K. Gable,et al.  The Saccharomyces cerevisiae TSC10/YBR265w Gene Encoding 3-Ketosphinganine Reductase Is Identified in a Screen for Temperature-sensitive Suppressors of the Ca2+-sensitive csg2Δ Mutant* , 1998, The Journal of Biological Chemistry.

[50]  V. Bankaitis,et al.  Essential role for diacylglycerol in protein transport from the yeast Golgi complex , 1997, nature.

[51]  John E. Coligan,et al.  Current Protocols in Protein Science , 1996 .