Preparation of high drug-loading celastrol nanosuspensions and their anti-breast cancer activities in vitro and in vivo

[1]  Wei Hou,et al.  Celastrol: Progresses in structure-modifications, structure-activity relationships, pharmacology and toxicology. , 2020, European journal of medicinal chemistry.

[2]  S. Jacob,et al.  Emerging role of nanosuspensions in drug delivery systems , 2020, Biomaterials Research.

[3]  Yifei Guo,et al.  Hydrous icaritin nanorods with excellent stability improves the in vitro and in vivo activity against breast cancer , 2020, Drug delivery.

[4]  Yanguang Cao,et al.  Mathematical modeling of the heterogeneous distributions of nanomedicines in solid tumors. , 2019, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[5]  Tao Mao,et al.  Celastrol inhibits growth and metastasis of human gastric cancer cell MKN45 by down‐regulating microRNA‐21 , 2019, Phytotherapy research : PTR.

[6]  Vijay Agarwal,et al.  Nanosuspension Technology: Recent Patents on Drug Delivery and their Characterizations , 2019, Recent patents on drug delivery & formulation.

[7]  K. Copps,et al.  IL1R1 is required for celastrol’s leptin sensitization and anti-obesity effects , 2019, Nature Network Boston.

[8]  Ying Zheng,et al.  Application of flash nanoprecipitation to fabricate poorly water-soluble drug nanoparticles , 2018, Acta pharmaceutica Sinica. B.

[9]  A. Fadda,et al.  Nanocrystals as effective delivery systems of poorly water soluble natural molecules. , 2019, Current medicinal chemistry.

[10]  Hong Wang,et al.  [Celastrol inhibits growth and increases apoptosis of human lung cancer A549 cells]. , 2018, Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology.

[11]  Mengfei Guo,et al.  A Tf-modified tripterine-loaded coix seed oil microemulsion enhances anti-cervical cancer treatment , 2018, International journal of nanomedicine.

[12]  S. Ku,et al.  Folate receptor-mediated celastrol and irinotecan combination delivery using liposomes for effective chemotherapy. , 2018, Colloids and surfaces. B, Biointerfaces.

[13]  L. Krenn,et al.  Natural Terpenoids Against Female Breast Cancer: A 5-year Recent Research. , 2018, Current medicinal chemistry.

[14]  A. Bishayee,et al.  Molecular targets of celastrol in cancer: Recent trends and advancements. , 2018, Critical reviews in oncology/hematology.

[15]  Ying Liu,et al.  Synergistic combination chemotherapy using carrier-free celastrol and doxorubicin nanocrystals for overcoming drug resistance. , 2018, Nanoscale.

[16]  J. Zhao,et al.  A Mechanistic Overview of Triptolide and Celastrol, Natural Products from Tripterygium wilfordii Hook F , 2018, Front. Pharmacol..

[17]  Andrew M. Bodratti,et al.  Formulation of Poloxamers for Drug Delivery , 2018, Journal of functional biomaterials.

[18]  O. Abdallah,et al.  Self-assembled phospholipid-based phytosomal nanocarriers as promising platforms for improving oral bioavailability of the anticancer celastrol. , 2018, International journal of pharmaceutics.

[19]  Xuan Huang,et al.  Simultaneous targeting therapy for lung metastasis and breast tumor by blocking the NF-κB signaling pathway using Celastrol-loaded micelles , 2018, Drug delivery.

[20]  J. Houtman,et al.  Natural Products Discovered in a High-Throughput Screen Identified as Inhibitors of RGS17 and as Cytostatic and Cytotoxic Agents for Lung and Prostate Cancer Cell Lines. , 2017, Journal of natural products.

[21]  J. Fonseca,et al.  Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases , 2017, Front. Med..

[22]  Rui-wei Gao,et al.  The ROS derived mitochondrial respirstion not from NADPH oxidase plays key role in Celastrol against angiotensin II-mediated HepG2 cell proliferation , 2016, Apoptosis.

[23]  Pui-Yu Ho,et al.  Doxorubicin-loaded biodegradable self-assembly zein nanoparticle and its anti-cancer effect: Preparation, in vitro evaluation, and cellular uptake. , 2016, Colloids and surfaces. B, Biointerfaces.

[24]  Youli Xiao,et al.  Competitive profiling of celastrol targets in human cervical cancer HeLa cells via quantitative chemical proteomics. , 2016, Molecular bioSystems.

[25]  Baojian Wu,et al.  Enhanced bioavailability of tripterine through lipid nanoparticles using broccoli-derived lipids as a carrier material. , 2015, International journal of pharmaceutics.

[26]  J. O’Shea,et al.  Celastrol, a Chinese herbal compound, controls autoimmune inflammation by altering the balance of pathogenic and regulatory T cells in the target organ , 2015, Clinical immunology.

[27]  Katherine Bourzac,et al.  Nanotechnology: Carrying drugs , 2012, Nature.

[28]  F Atyabi,et al.  Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents , 2011, International journal of nanomedicine.

[29]  A. Fahr,et al.  Nano- and micro-particulate formulations of poorly water-soluble drugs by using a novel optimized technique. , 2006, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[30]  U. Olsson,et al.  Amorphous drug nanosuspensions. 1. Inhibition of Ostwald ripening. , 2006, Langmuir : the ACS journal of surfaces and colloids.

[31]  P. Alexandridis,et al.  Physicochemical aspects of drug delivery and release from polymer-based colloids , 2000 .

[32]  Christine Allen,et al.  Nano-engineering block copolymer aggregates for drug delivery , 1999 .