Higher circulating androgens and higher physical activity levels are associated with less central adiposity and lower risk of cardiovascular death in older men

Low endogenous sex hormones and low physical activity (PA) levels have been associated with CVD risk. Whether these interact to influence CVD outcomes remains unclear. We assessed whether sex hormone concentrations and PA were additively associated with lower central adiposity and CVD risk.

[1]  K. Moreau,et al.  Effects of Testosterone and Progressive Resistance Exercise on Vascular Function in Older Men. , 2018, Journal of applied physiology.

[2]  B. Yeap,et al.  Testosterone treatment in older men: clinical implications and unresolved questions from the Testosterone Trials. , 2018, The lancet. Diabetes & endocrinology.

[3]  F. Blyth,et al.  Evaluating Calculated Free Testosterone as a Predictor of Morbidity and Mortality Independent of Testosterone for Cross-sectional and 5-Year Longitudinal Health Outcomes in Older Men: The Concord Health and Ageing in Men Project , 2018, The journals of gerontology. Series A, Biological sciences and medical sciences.

[4]  Frederick C W Wu,et al.  Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline. , 2018, The Journal of clinical endocrinology and metabolism.

[5]  Francesca N. Delling,et al.  Heart Disease and Stroke Statistics—2018 Update: A Report From the American Heart Association , 2018, Circulation.

[6]  B. Yeap Testosterone and its metabolites: differential associations with cardiovascular and cerebrovascular events in men , 2017, Asian journal of andrology.

[7]  M. Knuiman,et al.  Greater physical activity and higher androgen concentrations are independently associated with lower cardiometabolic risk in men , 2017, Clinical endocrinology.

[8]  S. Sidney,et al.  Association of Testosterone Replacement With Cardiovascular Outcomes Among Men With Androgen Deficiency , 2017, JAMA internal medicine.

[9]  M. Budoff,et al.  Testosterone Treatment and Coronary Artery Plaque Volume in Older Men With Low Testosterone , 2017, JAMA.

[10]  A. Matsumoto,et al.  A Perspective on Middle-Aged and Older Men With Functional Hypogonadism: Focus on Holistic Management , 2017, The Journal of clinical endocrinology and metabolism.

[11]  D. Kong,et al.  Exercise improves the effects of testosterone replacement therapy and the durability of response after cessation of treatment: a pilot randomized controlled trial , 2016, Asian journal of andrology.

[12]  F. Blyth,et al.  Temporal Changes in Androgens and Estrogens Are Associated With All-Cause and Cause-Specific Mortality in Older Men. , 2016, The Journal of clinical endocrinology and metabolism.

[13]  H. May,et al.  Impact of Testosterone Replacement Therapy on Myocardial Infarction, Stroke, and Death in Men With Low Testosterone Concentrations in an Integrated Health Care System. , 2016, The American journal of cardiology.

[14]  S. Studenski,et al.  Bioavailable Testosterone Linearly Declines Over A Wide Age Spectrum in Men and Women From The Baltimore Longitudinal Study of Aging. , 2016, The journals of gerontology. Series A, Biological sciences and medical sciences.

[15]  S. Resnick,et al.  Effects of Testosterone Treatment in Older Men. , 2016, The New England journal of medicine.

[16]  B. Dawn,et al.  Normalization of testosterone level is associated with reduced incidence of myocardial infarction and mortality in men. , 2015, European heart journal.

[17]  Lee Smith,et al.  Patterns and correlates of physical activity behaviour over 10 years in older adults: prospective analyses from the English Longitudinal Study of Ageing , 2015, BMJ Open.

[18]  G. Hankey,et al.  In older men, higher plasma testosterone or dihydrotestosterone is an independent predictor for reduced incidence of stroke but not myocardial infarction. , 2014, The Journal of clinical endocrinology and metabolism.

[19]  L. Ferrucci,et al.  Testosterone, Sex Hormone-Binding Globulin and the Metabolic Syndrome in Men: An Individual Participant Data Meta-Analysis of Observational Studies , 2014, PloS one.

[20]  G. Hankey,et al.  In older men an optimal plasma testosterone is associated with reduced all-cause mortality and higher dihydrotestosterone with reduced ischemic heart disease mortality, while estradiol levels do not predict mortality. , 2014, The Journal of clinical endocrinology and metabolism.

[21]  J. Finkelstein,et al.  Gonadal steroids and body composition, strength, and sexual function in men. , 2013, The New England journal of medicine.

[22]  M. E. Cress,et al.  Effects of testosterone and progressive resistance exercise in healthy, highly functioning older men with low-normal testosterone levels. , 2013, The Journal of clinical endocrinology and metabolism.

[23]  G. Hankey,et al.  Reference ranges and determinants of testosterone, dihydrotestosterone, and estradiol levels measured using liquid chromatography-tandem mass spectrometry in a population-based cohort of older men. , 2012, The Journal of clinical endocrinology and metabolism.

[24]  W. Brown,et al.  Are Active Australia physical activity questions valid for older adults? , 2010, Journal of science and medicine in sport.

[25]  A. Jette,et al.  Adverse events associated with testosterone administration. , 2010, The New England journal of medicine.

[26]  A. Silman,et al.  Identification of late-onset hypogonadism in middle-aged and elderly men. , 2010, The New England journal of medicine.

[27]  G. Hankey,et al.  Low free testosterone predicts frailty in older men: the health in men study. , 2010, The Journal of clinical endocrinology and metabolism.

[28]  David Handelsman,et al.  Development and validation of a sensitive liquid chromatography-tandem mass spectrometry assay to simultaneously measure androgens and estrogens in serum without derivatization. , 2009, Clinica chimica acta; international journal of clinical chemistry.

[29]  D. Mellström,et al.  Low serum testosterone and estradiol predict mortality in elderly men. , 2009, The Journal of clinical endocrinology and metabolism.

[30]  G. Hankey,et al.  Lower testosterone levels predict incident stroke and transient ischemic attack in older men. , 2009, The Journal of clinical endocrinology and metabolism.

[31]  G. Hankey,et al.  Healthier lifestyle predicts higher circulating testosterone in older men: the Health In Men Study , 2009, Clinical endocrinology.

[32]  Leon Flicker,et al.  Cohort Profile: The Health In Men Study (HIMS). , 2009, International journal of epidemiology.

[33]  A. J. Bass,et al.  A decade of data linkage in Western Australia: strategic design, applications and benefits of the WA data linkage system. , 2008, Australian health review : a publication of the Australian Hospital Association.

[34]  C. Ulrich,et al.  Effect of exercise on serum sex hormones in men: a 12-month randomized clinical trial. , 2008, Medicine and science in sports and exercise.

[35]  A. King,et al.  Physical activity and public health in older adults: recommendation from the American College of Sports Medicine and the American Heart Association. , 2007, Medicine and science in sports and exercise.

[36]  A. King,et al.  American College of Sports Medicine and the American Heart Association Physical Activity and Public Health in Older Adults. Recommendation From the , 2007 .

[37]  Fernando Costa,et al.  Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. , 2005, Circulation.

[38]  P. Roberson,et al.  Effects of muscle strength training and testosterone in frail elderly males. , 2005, Medicine and science in sports and exercise.

[39]  Shalender Bhasin,et al.  Older men are as responsive as young men to the anabolic effects of graded doses of testosterone on the skeletal muscle. , 2005, The Journal of clinical endocrinology and metabolism.

[40]  D. Grobbee,et al.  Measures of bioavailable serum testosterone and estradiol and their relationships with muscle strength, bone density, and body composition in elderly men. , 2000, The Journal of clinical endocrinology and metabolism.