Loop-Configuration for Plug Flow Crystallization Process Development

[1]  A. Myerson,et al.  Continuous Crystallization and Its Potential Use in Drug Substance Manufacture: A Review , 2022, Journal of Crystal Growth.

[2]  Clifford V Rossi.  A Comparative Investment Analysis of Batch Versus Continuous Pharmaceutical Manufacturing Technologies , 2022, Journal of pharmaceutical innovation.

[3]  R. Rota,et al.  Influence of Buoyancy Effects on the Mixing Process and RTD in a Side-Injection Reactor Equipped with Static Mixers , 2021, Industrial & Engineering Chemistry Research.

[4]  R. Rota,et al.  Mixing Efficiency and Residence Time Distributions of a Side-Injection Tubular Reactor Equipped with Static Mixers , 2021, Industrial & Engineering Chemistry Research.

[5]  K T Thomas,et al.  CFD Analysis of a Kenics Static Mixer with a Low Pressure Drop under Laminar Flow Conditions , 2021 .

[6]  B. Likozar,et al.  Continuous Crystallization Processes in Pharmaceutical Manufacturing: A Review , 2020, Organic Process Research & Development.

[7]  Michael A. Lovette,et al.  Perspectives on the Current State, Challenges, and Opportunities in Pharmaceutical Crystallization Process Development , 2020 .

[8]  Andrew J. Maloney,et al.  A Virtual Plant for Integrated Continuous Manufacturing of a Carfilzomib Drug Substance Intermediate, Part 3: Manganese-Catalyzed Asymmetric Epoxidation, Crystallization, and Filtration , 2020, Organic Process Research & Development.

[9]  N. Kockmann,et al.  Two-Phase Flow in a Coiled Flow Inverter: Process Development from Batch to Continuous Flow , 2020 .

[10]  K. Nigam,et al.  Process Intensification of Continuous Antisolvent Crystallization Using a Coiled Flow Inverter , 2020, Industrial & Engineering Chemistry Research.

[11]  A. Myerson,et al.  Mixed-Suspension, Mixed-Product Removal Studies of Ciprofloxacin from Pure and Crude Active Pharmaceutical Ingredients: The Role of Impurities on Solubility and Kinetics , 2019, Crystal Growth & Design.

[12]  C. Burcham,et al.  Continuous Manufacturing in Pharmaceutical Process Development and Manufacturing. , 2018, Annual review of chemical and biomolecular engineering.

[13]  Hermann Nirschl,et al.  Continuous Downstream Processing of Amino Acids in a Modular Miniplant , 2018 .

[14]  Stefan Turek,et al.  Analysis of Crystal Size Dispersion Effects in a Continuous Coiled Tubular Crystallizer: Experiments and Modeling , 2018 .

[15]  W. Liebenberg,et al.  Water and the relationship to the crystal structure stability of azithromycin , 2018, Journal of Thermal Analysis and Calorimetry.

[16]  Piotr Synowiec,et al.  Study of fluid dynamic conditions in the selected static mixers part II-determination of the residence time distribution , 2017 .

[17]  Maximilian O. Besenhard,et al.  Crystal Engineering in Continuous Plug-Flow Crystallizers , 2017, Crystal growth & design.

[18]  Herman J. M. Kramer,et al.  Residence time distribution of dispersed liquid and solid phase in a continuous oscillatory flow baffled crystallizer , 2017 .

[19]  Norbert Kockmann,et al.  Design of a Continuous Tubular Cooling Crystallizer for Process Development on Lab-Scale , 2016 .

[20]  Alastair J. Florence,et al.  Oscillatory flow reactors (OFRs) for continuous manufacturing and crystallization , 2015 .

[21]  Xiuzhen Huang,et al.  Goldindec: A Novel Algorithm for Raman Spectrum Baseline Correction , 2015, Applied spectroscopy.

[22]  Richard D. Braatz,et al.  Indirect Ultrasonication in Continuous Slug-Flow Crystallization , 2015 .

[23]  Johannes Khinast,et al.  Crystal Size Control in a Continuous Tubular Crystallizer , 2015 .

[24]  Johannes G. Khinast,et al.  Continuous Crystallization of Proteins in a Tubular Plug-Flow Crystallizer , 2015, Crystal growth & design.

[25]  Christopher L. Burcham,et al.  Regions of attainable particle sizes in continuous and batch crystallization processes , 2014 .

[26]  Brian Glennon,et al.  Development and Characterization of a Single Stage Mixed-Suspension, Mixed-Product-Removal Crystallization Process with a Novel Transfer Unit , 2014 .

[27]  R. Braatz,et al.  Continuous-Flow Tubular Crystallization in Slugs Spontaneously Induced by Hydrodynamics , 2014 .

[28]  Yumei Kai,et al.  Solubility of glycine in binary system of ethanol+water solvent mixtures: Experimental data and thermodynamic modeling , 2013 .

[29]  Brian Glennon,et al.  Characterization of the anti-solvent batch, plug flow and MSMPR crystallization of benzoic acid , 2013 .

[30]  S. Adichtchev,et al.  Glycine phases formed from frozen aqueous solutions: revisited. , 2012, The Journal of chemical physics.

[31]  B. Glennon,et al.  A Calibration-Free Application of Raman Spectroscopy to the Monitoring of Mannitol Crystallization and Its Polymorphic Transformation , 2010 .

[32]  Allan S. Myerson,et al.  Continuous Plug Flow Crystallization of Pharmaceutical Compounds , 2010 .

[33]  Marco Mazzotti,et al.  Estimating Crystal Growth Rates Using in situ ATR-FTIR and Raman Spectroscopy in a Calibration-Free Manner , 2009 .

[34]  Gerry Steele,et al.  Continuous Crystallization of Pharmaceuticals Using a Continuous Oscillatory Baffled Crystallizer , 2009 .

[35]  S. Hirschberg,et al.  An improvement of the Sulzer SMX™ static mixer significantly reducing the pressure drop , 2009 .

[36]  R. Braatz,et al.  Modeling and Computational Fluid Dynamics−Population Balance Equation−Micromixing Simulation of Impinging Jet Crystallizers , 2009 .

[37]  M. Mazzotti,et al.  Calibration-free quantitative application of in situ Raman spectroscopy to a crystallization process. , 2008, Analytical chemistry.

[38]  David W. Agar,et al.  Liquid−Liquid Slug Flow in a Capillary: An Alternative to Suspended Drop or Film Contactors , 2007 .

[39]  Rustem F Ismagilov,et al.  Time-controlled microfluidic seeding in nL-volume droplets to separate nucleation and growth stages of protein crystallization. , 2006, Angewandte Chemie.

[40]  A. Myerson,et al.  Laboratory Scale Batch Crystallization and the Role of Vessel Size , 2006 .

[41]  Ying Liu,et al.  CFD predictions for chemical processing in a confined impinging‐jets reactor , 2006 .

[42]  Edward L. Paul,et al.  Organic crystallization processes , 2005 .

[43]  Wojciech Orciuch,et al.  Interaction between Mixing, Chemical Reactions, and Precipitation , 2005 .

[44]  Heinrich Hofmann,et al.  Calcium carbonate precipitation using new segmented flow tubular reactor , 2000 .

[45]  C. Viseras,et al.  The effect of recrystallization on the crystal growth, melting point and solubility of ketoconazole , 1995 .

[46]  D. Pritchard,et al.  A study of mass transfer in yeast in a pulsed baffled bioreactor , 1995, Biotechnology and bioengineering.

[47]  M. Baird,et al.  Characteristics of a countercurrent reciprocating plate bubble column. II. Axial mixing and mass transfer , 1988 .

[48]  Ji Ir,et al.  PRESSURE DROP AND HOMOGENIZATION EFFICIENCY OF A MOTIONLESS MIXER , 1982 .

[49]  X. Wang,et al.  Novel Impinging Jet and Continuous Crystallizer Design for Rapid Reactive Crystallization of Pharmaceuticals , 2015 .

[50]  Z. Nagy,et al.  Anti-Fouling Control of Plug-Flow Crystallization via Heating and Cooling Cycle , 2015 .