The when and wheres of CDC25 phosphatases.

[1]  Paul Russell,et al.  cdc25 + functions as an inducer in the mitotic control of fission yeast , 1986, Cell.

[2]  K. Sadhu,et al.  p55CDC25 is a nuclear protein required for the initiation of mitosis in human cells. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[3]  U. Strausfeld,et al.  cdc25 is a nuclear protein expressed constitutively throughout the cell cycle in nontransformed mammalian cells , 1992, The Journal of cell biology.

[4]  E. Karsenti,et al.  Phosphorylation and activation of human cdc25‐C by cdc2‐‐cyclin B and its involvement in the self‐amplification of MPF at mitosis. , 1993, The EMBO journal.

[5]  E. Karsenti,et al.  Activation of the phosphatase activity of human cdc25A by a cdk2‐cyclin E dependent phosphorylation at the G1/S transition. , 1994, The EMBO journal.

[6]  S. Ogg,et al.  Purification of a serine kinase that associates with and phosphorylates human Cdc25C on serine 216. , 1994, The Journal of biological chemistry.

[7]  H Nojima,et al.  Cdc25A is a novel phosphatase functioning early in the cell cycle. , 1994, The EMBO journal.

[8]  D. Beach,et al.  14-3-3 proteins associate with cdc25 phosphatases. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[9]  D. Beach,et al.  Cdc25 cell-cycle phosphatase as a target of c-myc , 1996, Nature.

[10]  N. Hayward,et al.  Cytoplasmic accumulation of cdc25B phosphatase in mitosis triggers centrosomal microtubule nucleation in HeLa cells. , 1996, Journal of cell science.

[11]  B. Gabrielli,et al.  Hyperphosphorylation of the N-terminal Domain of Cdc25 Regulates Activity toward Cyclin B1/Cdc2 But Not Cyclin A/Cdk2* , 1997, The Journal of Biological Chemistry.

[12]  C. Cans,et al.  Phosphorylation of Human CDC25B Phosphatase by CDK1-Cyclin A Triggers Its Proteasome-dependent Degradation* , 1997, The Journal of Biological Chemistry.

[13]  S. Elledge,et al.  Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. , 1997, Science.

[14]  C. Peng,et al.  Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. , 1997, Science.

[15]  C. Peng,et al.  C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding. , 1998, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[16]  S. Elledge,et al.  Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. , 1998, Science.

[17]  W. Ansorge,et al.  The cdc25B phosphatase is essential for the G2/M phase transition in human cells. , 1998, Journal of cell science.

[18]  C. Fisher,et al.  Antisense phosphorothioate oligonucleotides specifically down‐regulate cdc25B causing S‐phase delay and persistent antiproliferative effects , 1998, International journal of cancer.

[19]  A. Kumagai,et al.  Binding of 14-3-3 proteins and nuclear export control the intracellular localization of the mitotic inducer Cdc25. , 1999, Genes & development.

[20]  I. Hoffmann,et al.  Ectopic Expression of Cdc25A Accelerates the G1/S Transition and Leads to Premature Activation of Cyclin E- and Cyclin A-Dependent Kinases , 1999, Molecular and Cellular Biology.

[21]  J. Decaprio,et al.  Cytoplasmic Localization of Human cdc25C during Interphase Requires an Intact 14-3-3 Binding Site , 1999, Molecular and Cellular Biology.

[22]  A. Forrest,et al.  Regulation of CDC25B phosphatases subcellular localization , 2000, Oncogene.

[23]  M. Molinari,et al.  Human Cdc25 A inactivation in response to S phase inhibition and its role in preventing premature mitosis , 2000, EMBO reports.

[24]  N. Mailand,et al.  Rapid destruction of human Cdc25A in response to DNA damage. , 2000, Science.

[25]  M. Waye,et al.  Specific interaction between 14-3-3 isoforms and the human CDC25B phosphatase , 2000, Oncogene.

[26]  B. Gabrielli,et al.  Centrosomal and cytoplasmic Cdc2/cyclin B1 activation precedes nuclear mitotic events. , 2000, Experimental cell research.

[27]  M. Morris,et al.  An Essential Phosphorylation-site Domain of Human cdc25C Interacts with Both 14-3-3 and Cyclins* , 2000, The Journal of Biological Chemistry.

[28]  P. Wipf,et al.  Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25. , 2001, Journal of medicinal chemistry.

[29]  H. Piwnica-Worms,et al.  Absence of Apparent Phenotype in Mice Lacking Cdc25C Protein Phosphatase , 2001, Molecular and Cellular Biology.

[30]  N. Mailand,et al.  The ATM–Chk2–Cdc25A checkpoint pathway guards against radioresistant DNA synthesis , 2001, Nature.

[31]  E. Appella,et al.  Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase , 2001, Nature.

[32]  Peter Wipf,et al.  Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors. , 2002, Molecular pharmacology.

[33]  V. Baldin,et al.  Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation , 2002, Oncogene.

[34]  E. Nishida,et al.  Plk1 promotes nuclear translocation of human Cdc25C during prophase , 2002, EMBO reports.

[35]  Hui Zhao,et al.  Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[36]  Jiri Bartek,et al.  Regulation of G2/M events by Cdc25A through phosphorylation‐dependent modulation of its stability , 2002, The EMBO journal.

[37]  L. Tessarollo,et al.  Cdc25b phosphatase is required for resumption of meiosis during oocyte maturation , 2002, Nature Genetics.

[38]  M. Pagano,et al.  Dual mode of degradation of Cdc25 A phosphatase , 2002, The EMBO journal.

[39]  J. Lazo,et al.  Dual G1 and G2 Phase Inhibition by a Novel, Selective Cdc25 Inhibitor 7-Chloro-6-(2-morpholin-4-ylethylamino)- quinoline-5,8-dione* , 2002, The Journal of Biological Chemistry.

[40]  Pierre Dubus,et al.  Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice , 2003, Nature Genetics.

[41]  Hui Zhao,et al.  Dual phosphorylation controls Cdc25 phosphatases and mitotic entry , 2003, Nature Cell Biology.

[42]  H. Piwnica-Worms,et al.  Chk1 Kinase Negatively Regulates Mitotic Function of Cdc25A Phosphatase through 14-3-3 Binding , 2003, Molecular and Cellular Biology.

[43]  Michele Pagano,et al.  Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage , 2003, Nature.

[44]  J. Pines,et al.  Active cyclin B1–Cdk1 first appears on centrosomes in prophase , 2003, Nature Cell Biology.

[45]  P. Kaldis,et al.  Cdk2 Knockout Mice Are Viable , 2003, Current Biology.

[46]  E. Appella,et al.  Regulation of Human Cdc25A Stability by Serine 75 Phosphorylation Is Not Sufficient to Activate a S-phase Checkpoint , 2003, Cell cycle.

[47]  J. Bartek,et al.  Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. , 2003, Cancer cell.

[48]  A. Gunasekera,et al.  Chk1 Mediates S and G2 Arrests through Cdc25A Degradation in Response to DNA-damaging Agents* , 2003, Journal of Biological Chemistry.

[49]  B. Monsarrat,et al.  Protein kinase CK2 regulates CDC25B phosphatase activity , 2003, Oncogene.

[50]  P. Vaglio,et al.  Functional cdc25C dual-specificity phosphatase is required for S-phase entry in human cells. , 2003, Molecular biology of the cell.

[51]  E. Bahassi,et al.  Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation , 2004, Oncogene.

[52]  H. Nakagama,et al.  Nuclear export signal in CDC25B. , 2004, Biochemical and biophysical research communications.

[53]  J. Rudolph,et al.  Cdc25 phosphatases and cancer. , 2004, Chemistry & biology.

[54]  B. Monsarrat,et al.  Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2–M transition , 2004, Journal of Cell Science.

[55]  A. Lindqvist,et al.  Characterisation of Cdc25B localisation and nuclear export during the cell cycle and in response to stress , 2004, Journal of Cell Science.

[56]  J. Lazo,et al.  Activation of the Raf‐1/MEK/Erk kinase pathway by a novel Cdc25 inhibitor in human prostate cancer cells , 2004, The Prostate.

[57]  V. Baldin,et al.  A novel synthetic inhibitor of CDC25 phosphatases: BN82002. , 2004, Cancer research.

[58]  P. Russell,et al.  The DNA damage response: sensing and signaling. , 2004, Current opinion in cell biology.

[59]  R. Medema,et al.  Polo-like kinase-1 controls recovery from a G2 DNA damage-induced arrest in mammalian cells. , 2004, Molecular cell.

[60]  N. Mailand,et al.  Centrosome-associated Chk1 prevents premature activation of cyclin-B–Cdk1 kinase , 2004, Nature Cell Biology.

[61]  P. Kaldis,et al.  Cdc2–cyclin E complexes regulate the G1/S phase transition , 2005, Nature Cell Biology.

[62]  K. Garber.  New checkpoint blockers begin human trials. , 2005, Journal of the National Cancer Institute.

[63]  H. Piwnica-Worms,et al.  Normal Cell Cycle and Checkpoint Responses in Mice and Cells Lacking Cdc25B and Cdc25C Protein Phosphatases , 2005, Molecular and Cellular Biology.

[64]  M. Cazales,et al.  CDC25B Phosphorylation by Aurora A Occurs at the G2/M Transition and is Inhibited by DNA Damage , 2005, Cell cycle.

[65]  A. Lindqvist,et al.  Cdc25A localisation and shuttling: characterisation of sequences mediating nuclear export and import. , 2005, Experimental cell research.

[66]  A. Lindqvist,et al.  Cdc25B cooperates with Cdc25A to induce mitosis but has a unique role in activating cyclin B1–Cdk1 at the centrosome , 2005, The Journal of cell biology.

[67]  Michael B Yaffe,et al.  MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation. , 2005, Molecular cell.

[68]  B. Monsarrat,et al.  CDC25B Phosphorylated by pEg3 Localizes to the Centrosome and the Spindle Poles at Mitosis , 2005, Cell cycle.

[69]  N. Sagata,et al.  Beta-TrCP recognizes a previously undescribed nonphosphorylated destruction motif in Cdc25A and Cdc25B phosphatases. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[70]  Bernard Ducommun,et al.  Inhibition of human tumor cell growth in vivo by an orally bioavailable inhibitor of CDC25 phosphatases , 2005, Molecular Cancer Therapeutics.