Improving the Reproducibility of the Cyclic Variation of Myocardial Backscatter

The goal of myocardial tissue characterization is to augment information provided by two- and three-dimensional echocardiographic imaging, Doppler blood flow and speckle- or Doppler-derived tissue motion. Tissue characterization based on the systematic variation of backscattered ultrasound during the cardiac cycle (‘cyclic variation’) appears to be effective in characterizing both focal and diffuse myocardial pathologies. Unfortunately, comparison of results from different laboratories is difficult because of a lack of consistency among the several reported methods of analyzing the cyclic variation data. The goals of the present work are to present an improved method of analysis and to demonstrate that apparent disagreements are attributable primarily to the distinct approaches employed by different investigators. The improved automated method for determining the magnitude of cyclic variation utilizes binomial smoothing and an average deviation method and was validated using data acquired from 23 patients. This method illustrates a systematic means for resolving differences between laboratories. This resolution facilitates future comparisons between the cyclic variation of myocardial backscatter and measurements derived, for example, from strain-related approaches.